Biomedical Sciences Research Centre Seminar Series
Antibodies as antigen carriers and adjuvants, a way to boost T cell responses
As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Sara Mangsbo, Uppsala University, Sweden presents: Antibodies as antigen carriers and adjuvants, a way to boost T cell responses.
- From: Wednesday 22 November 2017, 1.10 pm
- To: Wednesday 22 November 2017, 2 pm
- Location: 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS
As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Sara Mangsbo, Uppsala University, Sweden presents a Skpe seminar: Antibodies as antigen carriers and adjuvants, a way to boost T cell responses.
Cellular immune response is critically important for an effective anti-tumor response. Immunotherapy of tumors is often focusing on boosting or inducing effector T cells as a way to target the tumor. Humoral responses on the other hand are considered more effective in a prophylactic setting, preventing disease onset. However, data support that monoclonal antibodies targeting tumor-specific antigens can induce a long-lasting T cell-mediated anti-tumor effect. This it thought to be mediated thru the formation of immune complexes, boosting cellular immune responses. Our group is, in collaboration with Dutch colleagues, focusing on boosting cellular immune responses thru synthetic long peptides. Naked peptides are fragile and rapidly degraded. We are making use of peptide conjugates that can be targeted by endogenous antibodies to form immune complexes, as a means to boost tumor specific T cells. This leads to both antigen protection, increased antigen uptake into antigen-presenting cells (APCs) and activation of the APC thru the interaction with innate receptors upon Fc engagement/ internalization.
This seminar is hosted by Stephanie McArdle.