Chemistry and Forensic Science Colloquium

Chiral organometallic chemistry for the preparation of substituted heterocycles

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As part of the School of Science and Technology Chemistry and Forensic Science Colloquium, Professor Iain Coldham, University of Sheffield presents: Chiral organometallic chemistry for the preparation of substituted heterocycles.

  • From: Wednesday 29 November 2017, 1 pm
  • To: Wednesday 29 November 2017, 2 pm
  • Location: 193, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, Ng11 8NS

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Event details

As part of the School of Science and Technology Chemistry and Forensic Science Colloquium, Professor Iain Coldham, University of Sheffield presents: Chiral organometallic chemistry for the preparation of substituted heterocycles.

Abstract:

Heterocycles constitute the majority of all known compounds. They are found widely in nature, such as in DNA, alkaloids, vitamins, etc. They are key components of pharmaceuticals, agrochemicals, polymers, colourants, etc. It is not surprising therefore that there are many different routes for their formation. We have been studying a simple approach to substituted heterocycles using organometallic chemistry and this talk will outline our results with alpha-amino organolithium species, prepared by deprotonation with the readily available base n-butyllithium. The reaction can be followed in situ by IR spectroscopy. The newly formed organolithiums can be trapped with a variety of electrophiles to give substituted products of relevance to the pharmaceutical industry in an overall C-H functionalisation approach. By using a chiral ligand, we can prepare products with high enantioselectivities. Current work is focused on this kinetic resolution chemistry and we will include a discussion of results in this area that provide novel, highly enantiomerically enriched substituted nitrogen-containing heterocycles.

This seminar is hosted by Professor John Wallis

All welcome.

Location details

Room/Building:

193, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
Ng11 8NS

Past event

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