Biomedical Sciences Research Seminar

Translational bioinformatics approaches towards assessment of preclinical disease models and inference of drug mechanisms

Atomic structure of a biological molecule
Seminars

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Deena Gendoo, NTU presents Translational bioinformatics approaches towards assessment of preclinical disease models and inference of drug mechanisms.

  • From: Wednesday 21 February 2018, 1.10 pm
  • To: Wednesday 21 February 2018, 2 pm
  • Location: 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Deena Gendoo, NTU presents Translational bioinformatics approaches towards assessment of preclinical disease models and inference of drug mechanisms.

Abstract:

Advances in personalized medicine remain challenged by the lack of effective characterization of preclinical models to study disease pathogenesis. In parallel, effective selection of therapeutics is hindered by a lack of understanding of pharmacological, biochemical, and mechanistic actions of drug behaviour. In this talk, I present a new pipeline for assessing disease model fidelity using whole-genome sequencing (WGS) data of patient-derived xenografts (PDX) and patient-derived organoids (PDO) in Pancreatic ductal adenocarcinoma (PDAC). I describe how this method can be coupled with another approach, Drug Network Fusion (DNF), towards inferring drug mechanisms of action for newly developed and existing compounds. Collectively, the presented approaches address the crucial link between translating experimental research conducted on preclinical models to their human counterparts, and the selection of drug candidates that are applicable for treatment of disease subtypes.

This seminar is hosted by Dr Amanda Coutts.

All welcome.

For any enquiries please contact Dr Amanda Coutts or Dr John Dickenson.

Location details

Room/Building:

282, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

Still need help?

+44 (0)115 941 8418