Biomedical Sciences Research Seminar

Identification of Novel Targets for The Treatment of Type 2 Diabetes

Atomic structure of a biological molecule
Seminars

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Michael Cripps, NTU presents Identification of Novel Targets for The Treatment of Type 2 Diabetes.

  • From: Wednesday 18 April 2018, 1.10 pm
  • To: Wednesday 18 April 2018, 2 pm
  • Location: 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Michael Cripps, NTU presents Identification of Novel Targets for The Treatment of Type 2 Diabetes.

Abstract

The worldwide prevalence of diabetes has risen to 8.5% among adults, which represents a staggering rise in prevalence from 4.7% in 1980. While some treatments work by increasing insulin secretion, over time their effectiveness decreases. The aim of my work is to develop new strategies that increase insulin secretion through mechanisms independent of current treatment options. In order to accomplish this I set about investigating the underlying disease pathophysiology, utilising a cellular model that replicates conditions of high sugar and fatty acids typically found in individuals with type 2 diabetes. Results show that under these conditions there is a sharp rise in reactive metabolites linked to advanced glycation and advanced lipidation end products. I will present data showing that carnosine, a physiological dipeptide, prevents adduction by these damaging molecules, and consequently enhances insulin secretion. Additional research is now focusing on gene expression of receptors linked to heterotrimeric G-protein signalling pathways, with the aim to ultimately develop novel pharmacological tools that modulate cAMP amplification of insulin secretion.

This seminar is hosted by Dr Mark Turner.

All welcome.

For any enquiries please contact Dr Amanda Coutts or Dr John Dickenson

Location details

Room/Building:

282, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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