Mathematical Sciences Research Centre Seminar Series

Numerical Simulation of the Active Cable with Stochastic Ion Channels

open book on table
Seminars

As part of the School of Science and Technology Mathematical Sciences Research Centre Seminar Series, Dr Ahmet Omurtag, NTU presents: Numerical Simulation of the Active Cable with Stochastic Ion Channels.

  • From: Wednesday 24 October 2018, 1 pm
  • To: Wednesday 24 October 2018, 2 pm
  • Location: 169, New Hall Block, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology Mathematical Sciences Research Centre Seminar Series, Dr Ahmet Omurtag, NTU presents: Numerical Simulation of the Active Cable with Stochastic Ion Channels.

Abstract

The ability to model neuronal networks efficiently and accurately is crucial for understanding their dauntingly complex information processing capabilities. We apply a spectral collocation technique to simulate neurites, following the Hodgkin-Huxley formalism. This is combined with stochastic models of ion channels in order to characterise the effects of channel noise on the response to synaptic inputs. Stochastic differential equation models of the ion channel are compared with the Markov chain model and direct simulation. Results indicate how channel noise drastically affects the stability of regular spiking, in ways which depend on the local ion channel density. These suggest that ion channel noise may impose a lower bound on the miniaturisation of neurons (and, by implication, brains) as computing machines.

All Welcome

This seminar is hosted by Dr Jonathan Crofts

For any enquiries please contact Dr David Chappell.

Location details

Room/Building:

169, New Hall Block

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

Still need help?

+44 (0)115 941 8418