Chemistry and Forensic Science Colloquium

Iron-sulfur cluster proteins as biological sensors

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Seminars

As part of the School of Science and Technology Chemistry and Forensic Science Colloquium Professor Nick Le Brun, University of East Anglia presents: Iron-sulfur cluster proteins as biological sensors.

  • From: Wednesday 28 November 2018, 1 pm
  • To: Wednesday 28 November 2018, 2 pm
  • Location: 193, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology Chemistry and Forensic Science Colloquium Professor Nick Le Brun, University of East Anglia presents: Iron-sulfur cluster proteins as biological sensors.

Iron-sulfur cluster proteins carry out multiple functions in life, including as regulators of gene transcription/translation in response to environmental stimuli.  In all known cases, the cluster acts as the sensory module, where the inherent reactivity/fragility of iron-sulfur clusters with small/redox active molecules is exploited to effect conformational changes that modulate binding to DNA regulatory sequences.  This promotes an often substantial re-programming of the cellular proteome that enables the organism or cell to adapt to, or counteract, its changing circumstances. Here, I will discuss recent progress in the structural and mechanistic characterization of iron-sulfur cluster regulators, focussing on regulatory proteins that are involved in sensing molecular oxygen, iron, and/or nitric oxide in bacteria.  In recent years, we have developed the use of mass spectrometry under conditions where iron-sulfur proteins remain folded and the cluster bound; aspects of this work will be discussed.

This seminar is hosted by Dr Warren Cross

All welcome.

For any queries please contact Dr Sophie Benjamin

Location details

Room/Building:

193, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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