Biomedical Sciences Research Seminar Series

Nanotech revolution in cancer treatment: the case of domestic acid

Atomic structure of a biological molecule
Seminars

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Michele Caraglia, Universita Degli Studi Della Campagnia “Luigi Vanvitelli”, Naples, Italy presents: Nanotech revolution in cancer treatment: the case of domestic acid.

  • From: Wednesday 30 January 2019, 1.10 pm
  • To: Wednesday 30 January 2019, 2 pm
  • Location: 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Michele Caraglia, Universita Degli Studi Della Campagnia “Luigi Vanvitelli”, Naples, Italy presents: Nanotech revolution in cancer treatment: the case of domestic acid.

Abstract

Glioblastoma (GBM) is a highly aggressive brain tumour with poor clinical outcome. The blood-brain barrier (BBB) is the most important limiting factor for drug delivery. We propose a new strategy for the treatment of GBM based on calcium phosphate self-assembled nanoparticles (PLCaP NPs) encapsulating zoledronic acid (ZOL) and conjugated with transferrin (Tf). We demonstrate also that these NPs are able to potentiate the anti-tumour activity of temozolomide (TMZ). Moreover, we have also developed different formulations of NPs efficiently encapsulating microRNAs (miRNAs) and with good delivering properties through the BBB. We have encapsulated in these NPs the microRNA-603 (miR-603) that is known as a O6-methylguanine DNA methyltransferase (MGMT, involved in the resistance to TMZ) suppressor. In vivo studies were performed and the formulation with the best in vitro efficiency (PLCaP NP DOTAP/CER-PEG ) had the best accumulation in brain tissue. These results open a new scenario in the delivery of either ZOL or miRNAs through the BBB.

This seminar is hosted by Dr Tariq Regard

All welcome.

For any enquiries please contact Dr Amanda Coutts

Location details

Room/Building:

282, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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