Engineering and Materials Research Seminar Series

Let’s get Hyped! – Cryogen free Hyperpolarisation as a tool for imaging metabolism

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Seminars

As part of the School of Science and Technology's Engineering and Materials Research Seminar Series, Dr Adam Gaunt, Cancer Research UK Cambridge Institute, University of Cambridge presents:Let’s get Hyped! – Cryogen free Hyperpolarisation as a tool for imaging metabolism.

  • From: Wednesday 8 May 2019, 1 pm
  • To: Wednesday 8 May 2019, 2 pm
  • Location: 015, CELS, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology's Engineering and Materials Research Seminar Series, Dr Adam Gaunt, Cancer Research UK Cambridge Institute, University of Cambridge presents:Let’s get Hyped! – Cryogen free Hyperpolarisation as a tool for imaging metabolism.

Abstract

In this talk I will present an exciting method for generating vast magnetic resonance signal enhancement on metabolic substrates that are relevant in imaging cancer metabolism. The technique used to achieve this is Dissolution Dynamic Nuclear Polarisation (Diss-DNP) which has been reported to achieve signal enhancements of more than 10,000.
I will give a general overview of some of the metabolic imaging work being conducted at the Cancer Research UK Cambridge Institute, along with more in-depth discussion of how our novel, cryogen free polariser is constructed and why it is exciting for the community.
Finally, the presence of free radical compounds that are integral to the DNP process has in the past caused problems for translating the technique to the clinical setting. I will aim to demonstrate a method of polarisation using non-persistent photo-generated radicals that can be quenched from the system before the dissolution process while retaining the nuclear spin polarisation (i.e. the MRI signal). This not only improves the applicability for clinical translation but also opens up potential for polarisation storage and transportation of hyperpolarised substrates to locations far from the polariser, reducing significantly footprint and the cost of using DNP for imaging.

This seminar is hosted by Dr Mike Newton &  Dr Ian Shuttleworth

All Welcome

For any enquires please contact Dr Ian Shuttleworth

Location details

Room/Building:

015, CELS

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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