Biomedical Sciences Research Seminar Series

3D-printed polymer scaffolds for mimicking the tumor micro-environment

Atomic structure of a biological molecule
Seminars

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Professor Sandra Van Vlierberghe, University of Gent presents: 3D-printed polymer scaffolds for mimicking the tumor micro-environment.

  • From: Wednesday 12 June 2019, 1.10 pm
  • To: Wednesday 12 June 2019, 2 pm
  • Location: ERD 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Professor Sandra Van Vlierberghe, University of Gent presents: 3D-printed polymer scaffolds for mimicking the tumor micro-environment.

Abstract

The tumor environment is recognized as an important factor in therapy outcome. However, current models focus on the cancer cells, while incorporating the stroma creates models with a higher clinical relevance. We have “tumor engineered” an in vivo model for peritoneal metastasis from ovarian cancer, a disease with a high mortality rate, that recapitulates the heterogeneity of a patient tumor at the microscopic level [1]. As carrier structure, we previously used a porous polylactic acid (PLA) scaffold. Unfortunately, tumor stiffness, an important parameter causing therapy failure, is neglected in this model. The stiffness in the model is determined by the PLA scaffold and not by tumor characteristics. By introducing a new polymer (AUP) [2] with tunable chemical structure, we can control the stiffness of the scaffold by altering the length of the PEG backbone.

In this respect, the design of appropriate polymers and their 3D printing capabilities are of paramount importance towards realizing more relevant in vitro cancer models.

Hosted by Dr Tarik Regad

All welcome.

For any enquiries please contact Dr John Dickenson

Location details

Room/Building:

ERD 282, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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