Biomedical Sciences Research Seminar Series

Transposable Element repression in the germline : piRNAs as guardians of the germline genome integrity

Atomic structure of a biological molecule
Seminars

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Emilie Brasset, University of Clermont Auvergne presents: Transposable Element repression in the germline : piRNAs as guardians of the germline genome integrity.

  • From: Wednesday 23 October 2019, 1.10 pm
  • To: Wednesday 23 October 2019, 2 pm
  • Location: ERD 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS

Past event

Event details

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr Emilie Brasset, University of Clermont Auvergne presents: Transposable Element repression in the germline : piRNAs as guardians of the germline genome integrity.

Abstract

For species survival, the germline must faithfully transmit genetic information to the progeny. Transposable elements (TEs) constitute a significant threat to genome stability due to their mobility. In the metazoan germline, their mobilization is limited by a class of small RNAs called PIWI-interacting RNAs (piRNAs) produced by dedicated genomic loci called piRNA clusters. Although the piRNA pathway is an adaptive genomic immunity system, it remains unclear how the germline gains protection from a new transposon invasion. To address this question, we analyze Drosophila melanogaster lines harboring a derepression of a retrotransposon in the somatic follicular cells and subsequent germline genome invasion. We show that the germline can protect itself by trapping invading somatic-specific TEs into germline piRNA clusters. This is the first demonstration of “auto-immunization” of a germline endangered by mobilization of a surrounding somatic TE.

Hosted by Dr Luigi De Girolamo

All welcome.

For any enquiries please contact Dr Amanda Coutts

Location details

Room/Building:

ERD 282, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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