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Biomedical Sciences Research Seminar Series

Host and HPV methylation play a cornerstone role in HPV-related cancer progression

Atomic structure of a biological molecule
Seminars

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr. Belinda Nedja, Queen Mary University of London presents: Host and HPV methylation play a cornerstone role in HPV-related cancer progression.

  • From: Wednesday 20 November 2019, 1.10 pm
  • To: Wednesday 20 November 2019, 2 pm
  • Location: ERD 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS
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Event details

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Dr. Belinda Nedja, Queen Mary University of London presents: Host and HPV methylation play a cornerstone role in HPV-related cancer progression.

Abstract

Background: HPV infection has a critical role in common dermatologic and sexually transmitted diseases, as well as in some of the most frequent cancers worldwide (7-8). The HPV-associated disease burden is higher than that reported for any other infectious agent worldwide, with a larger burden observed in women than in men. The rapidly rising male share of the total burden underlines the prioritization of male HPV-related disease in prevention programmes, especially oropharyngeal cancer.

Methods: Here we present an overview of S5 classifier performance at detecting high grade lesions across cervical cancer, anal cancer. Oropharyngeal and vulval cancer contrasting the similarities and the differences. Use used samples from various case control studies to illustrate the ability of S5 classifier to detect high grade lesions in HPV _related cancers. DNA was extracted and bisulfite conversion was carried out followed by pyrosequencing assays for the 6 S5 markers. Average methylation was calculated for each marker and the S5 score calculated.

Results: Despite different cancer sites S5 methylation classifier is accurately discriminating between high grade and low grade lesions and cancer. This results suggest common progression pathways that one need to investigate further.

Hosted by Dr Mark Turner

All welcome.

For any enquiries please contact Dr Amanda Coutts

Location details

Room/Building:

ERD 282, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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