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Biomedical Sciences Research Seminar Series

Novel (lymph)angiogenic factors and their receptors in human endothelial cells - from discovery towards translational research

Atomic structure of a biological molecule
Seminars

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Leonid Nikitenko, University of Hull presents: Novel (lymph)angiogenic factors and their receptors in human endothelial cells - from discovery towards translational research.

  • From: Wednesday 15 January 2020, 1.10 pm
  • To: Wednesday 15 January 2020, 2 pm
  • Location: ERD 282, Erasmus Darwin, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS
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Past event

Event details

As part of the School of Science and Technology Biomedical Sciences Research Centre Seminar Series, Leonid Nikitenko, University of Hull presents: Novel (lymph)angiogenic factors and their receptors in human endothelial cells - from discovery towards translational research.

Abstract

Endothelial cells of blood and lymphatic vessels play significant roles in the pathogenesis of cancer, cardiovascular disease and lymphoedema. G protein-coupled receptors (GPCRs) are the most intensively studied drug targets, largely due to their substantial involvement in human pathophysiology and their pharmacological tractability. The focus of this talk will be on GPCR calcitonin receptor-like receptor (CLR) in human endothelial cells and its three putative agonists – adrenomedullin, intermedin and calcitonin gene-related peptide. Specifically, I will explore the prognostic utility of CLR in human tissues and its potential application as a target for drug development in pathologies associated with aberrant angiogenesis and/or vascular and lymphatic insufficiency. This will be done in the context of the findings from our previous and most recent studies aimed at dissecting the properties of CLR endogenously expressed in primary human blood and lymphatic endothelial cells and its agonists as (lymph)angiogenic factors.

Hosted by Dr Heidi Sowter

All welcome.

For any enquiries please contact Dr Amanda Coutts

Location details

Room/Building:

ERD 282, Erasmus Darwin

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
 Nottingham
 NG11 8NS

Past event

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