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Chemistry and Forensic Science Colloquium

Catalysts for asymmetric reduction

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Seminars

As part of the School of Science and Technology Chemistry and Forensic Science Colloquium Professor Simon Jones, University of Sheffield presents: Catalysts for asymmetric reduction.

  • From: Wednesday 4 March 2020, 1 pm
  • To: Wednesday 4 March 2020, 2 pm
  • Location: CTLP 09 + 10, Clifton Teaching and Learning Building, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, NG11 8NS
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Event details

As part of the School of Science and Technology Chemistry and Forensic Science Colloquium Professor Simon Jones, University of Sheffield presents: Catalysts for asymmetric reduction.

Abstract

Cost effective and efficient methods for the production of small molecule building blocks for use in medicinal and agrochemical applications remains a challenge for many academic and process chemistry groups. Safe transition from the laboratory to an industrial environment requires careful consideration of many reaction parameters, including solvent, catalyst and specialist equipment.

Research from this group has examined the applicability of catalysts to effect the asymmetric reduction of prochiral C=O and C=N bonds. We have examined a number of catalyst and reduction systems, in each case looking at the potential translation from the laboratory to an industrial environment. This talk will provide an overview of the chemistry discovered to-date, demonstrating ways to access chiral alcohols and amines.

Biography

Dr Jones received his first degree from the University of Southampton in 1991, then moved to the University of Wales, Cardiff, to carry out his Ph.D. under the supervision of the late Dr D. R. Kelly on the synthesis of nitroxide spin labelled disaccharides as novel probes to investigate the biochemical mechanism of septic shock. He spent a short postdoctoral period at the Cancer Research Institute, Arizona State University with Professor G. R. Pettit, followed by another postdoctoral position with Professor Steve Davies at the Dyson Perrins Laboratory, Oxford. He was appointed as a Lecturer in Organic Chemistry at the University of Newcastle upon Tyne in January 1999, moved to the University of Sheffield in June 2003, promoted through to Reader in January 2013, and Professor in 2017.

His research group work on developing new ways to prepare small molecule chiral building blocks, using a combination of chiral auxiliary and catalyst strategies, with particular emphasis on asymmetric reduction, Diels-Alder cycloadditions and organophosphorus chemistry. These synthetic strategies have been applied in biological applications, including use as anti-inflammatory and anti-microbial agents, as well as molecular probes.

Hosted by Dr Christopher Garner

All welcome

For enquires please contact Dr Sophie Benjamin

Location details

Room/Building:

CTLP 09 + 10, Clifton Teaching and Learning Building

Address:

Nottingham Trent University
Clifton Campus
Clifton Lane
Nottingham
NG11 8NS

Past event

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