Doctoral student in a lab

Investigating the Neurovascular Unit in Diabetic Neuropathic Pain

  • School: School of Science and Technology
  • Starting: 2018 / 2019
  • Funding: UK student / EU student (non-UK) / International student (non-EU) / Self-funded

Overview

A fully funded 3 year PhD studentship is available within the School of Science and Technology, supported by EFSD/Boehringer Ingelheim European Research Programme in Microvascular Complications of Diabetes. The project is based in research laboratories specialising in pain (Dr Richard Hulse) and diabetes (Prof Philip McTernan), in collaboration with the Tumour and Vascular Biology Laboratories, University of Nottingham (Prof David Bates).

Neuropathic pain is a burden many people with diabetes suffer from. Despite this extensive clinical need for effective analgesic treatment, many current painkilling treatments are ineffective and/or have significant adverse side-effects. Our research focuses upon understanding the diabetes induced pathology surrounding sensory neuronal degeneration and pain. Diabetic patients are highly susceptible to microvascular disease, which is associated with neurodegenerative disease in these patients. Our recent work demonstrates that diabetes damages the blood vessels in the sensory nervous system (Ved et al. 2018. J. Physiol).

Your research project will find out how these neuro-vascular interactions can alter pain processing. Identifying how blood vessels and sensory neurons communicate will allow you to find out how alterations in these pathways contribute to the development of diabetic neuropathy, opening up new treatment options for people with diabetic pain. Working closely with Dr Hulse, you will gain high quality training in in vivo and in vitro methodologies including rodent models of diabetes, electrophysiological recordings and measurement of microvascular blood flow in vivo, experimental design and analysis, and work within a growing team of scientists passionate about understanding disease processes in diabetes.

Supervisors

Dr Richard Hulse

Prof  Philip McTernan

Prof David Bates

Entry qualifications

You should have a good quality BSc in a relevant subject (neuroscience, physiology, biomedical science, or equivalent).

How to apply

How to apply

The deadline for applications is 12 pm (UK time) 2 November 2018.

Download an application form here.
Please make sure you take a look at our application guidance notes before making your application.

Further information on how to apply can be found on this page.

Fees and funding

This studentship is open to applicants from the UK/EU only. The studentship will pay UK/EU tuition fees (currently set at £4,260 for 2018/19 and are revised annually). It will also provide a maintenance stipend of approximately £14,777 per year for three years (the stipend is linked to the RCUK rate, starting in 2018).

This PhD studentship is supported by EFSD/Boehringer Ingelheim European Research Programme in Microvascular Complications of Diabetes.

Guidance and support

Further information on guidance and support can be found on this page.

Still need help?

Dr. Richard Hulse