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Development of a novel framework for the preclinical evaluation and optimisation of total joint replacements S&T51

  • School: School of Science and Technology
  • Study mode(s): Full-time / Part-time
  • Starting: 2022
  • Funding: UK student / EU student (non-UK) / International student (non-EU) / Fully-funded

Overview

NTU's Fully-funded PhD Studentship Scheme 2022

Project ID: S&T51

Treatment for patients with osteoarthritis costs the NHS more than £5B per year. According to the latest National Joint Registry (NJR) report, the number of recorded joint replacements in the UK were more than 235,000 procedures. More than 10% of the recorded joint replacements were revision procedures (NJR, 2020).

Preclinical tribological evaluation and understanding of long-term performance are critical for successful total joint replacements (TJR). To support design and development of more robust devices, match the right design to the right patient, and to efficiently evaluate and optimise current and emerging TJR, advanced preclinical evaluation and optimisation systems are required.

This project will develop a combination of experimental and computational test methods to advance a novel framework for accurate preclinical evaluation and optimisation of TJR. For the first time, the material parameters of the TJR bearings will be independently measured using realistic experimental studies especially designed to closely mimic and be representative of the operating conditions of TJR. In addition, the framework will, for the first time, utilise a combination of different indicators, such as loosening, wear, and wear scars/debris (NJR, 2020), to predict failure of TJR.  
The developed framework will be adapted as a design tool and will be applied to an existing hip replacement and the independent experimental data for this hip design will be used to validate the framework. This case study will demonstrate the accuracy of the novel framework as a preclinical evaluation tool, to promote the adoption of the framework as a preclinical design and optimisation tool. Although hip prosthesis, which have one of the largest market shares in orthopaedics field, will be used in the case study, the framework will be also applicable to other implants, such as knee, shoulder, and ankle prosthesis.

The proposed research will deliver major scientific advances in preclinical evaluation and optimisation of TJR. The research, which will be complemented by multidisciplinary expertise training, career development, and opportunities for secondments to build a wider industrial and regulatory expertise, will allow current and emerging TJR to be examined and optimised at low cost and time. The proposed breakthrough in preclinical evaluation and optimisation of TJR will support the design and development of more robust devices, match the right design to the right patient, efficiently evaluate and optimise current and emerging products, and will significantly improve the outcome and reduce the revision rate of TJR, benefitting patients, healthcare providers, industry, and economy.

The supervisory team consists of Director of Studies Dr Abdellatif Abdelgaied (NTU) and Co-Supervisors Dr Qimei Zhang (NTU), Dr Mazen AlHajjar (DePuy J&J company), Dr Leiming Gao (NTU) and Professor John Hunt (NTU).

School strategic research priority

The project aligns with the NTU Centre for Health, Ageing and Understanding Disease (CHAUD).

Entry qualifications

For the eligibility criteria, visit our studentship application page.

How to apply

For guidance and to make an application, please visit our studentship application page. The application deadline is Friday 14 January 2022.

Fees and funding

This is part of NTU's 2022 fully-funded PhD Studentship Scheme.

Guidance and support

Download our full applicant guidance notes for more information.

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