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Development of bioinspired transformations in organic synthesis S&T53

  • School: School of Science and Technology
  • Study mode(s): Full-time / Part-time
  • Starting: 2022
  • Funding: UK student / EU student (non-UK) / International student (non-EU) / Fully-funded

Overview

NTU's Fully-funded PhD Studentship Scheme 2022

Project ID: S&T53

The synthesis of the majority of products involves one or more chemical processes. Only a small fraction of the natural resources are retained in the products after chemical conversion. The development of new chemical processes that improve synthesis efficiency by adhering to the principles of green chemistry is increasingly in demand. New synthesis methods are needed to achieve this goal. In spite of the great progress in recent years, there is a growing demand for new and efficient methods for the synthesis of various chemical compounds.

The main aim of this project is to develop new technologies for useful and sustainable chemical transformation and synthesis methods. To achieve this goal, several sub-objectives will be pursued. We will focus on the development of efficient, practical chemical transformations without the use of transition metals and with drastically minimised amounts of waste and by-products. A unique feature of the proposed research is the use of simple chemicals without prior functionalisation. A key feature of the project is that the inspiration for it is based on knowledge about organic transformations in Nature that are catalysed by different enzymes. This would lead to the development of sustainable bioorthogonal methods that can take place in living cells. Finally, we will focus on the development of new efficient and superior catalytic systems. As a prerequisite, small organic molecules will be systematically evaluated and the knowledge gained will be applied to the development of ground-breaking chemical processes. The developed novel reaction methodology will be applied for the preparation of focused compound libraries. Obtained compounds will be studied in various biological assays in order to induce perturbation in biological processes.

The project was designed by Dr. Andrey Antonchick, who has extensive experience in organic synthesis, catalysis, and chemical biology.

School strategic research priority

The proposed project aligns with the Centre for Health, Ageing and Understanding Disease.

Entry qualifications

For the eligibility criteria, visit our studentship application page.

How to apply

For guidance and to make an application, please visit our studentship application page. The application deadline is Friday 14 January 2022.

Fees and funding

This is part of NTU's 2022 fully-funded PhD Studentship Scheme.

Guidance and support

Download our full applicant guidance notes for more information.

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