Overview
Mechanisms of pathogenesis and evolution of virulence.
The Pathogen Research Group studies a range of organisms of importance to human health, including bacteria that cause severe infections in neonates (Cronobacter) and the elderly (drug resistant E. coli), as well as foodborne pathogens (Camyplobacter, Yersinia), and the protozoan Leishmania, an intracellular parasite causing around two million infections worldwide.
Our research is a mixture of classical bacterial genetics and pathogenesis research, in addition to population genetics and genomics to uncover mechanisms of pathogenesis and evolution of virulence. Using genomics we also analyse phage sequences to quantify polymorphism frequency in populations and thereby characterise evolution in experimental settings.
Related staff
- Dr Selman Ali – Leishmania, immune response
- Dr Ben Dickins – Phage, experimental evolution, genomic analysis
- Professor Steve Forsythe – Cronobacter, neonatal infections, MLST, genomics
- Dr Michael Loughlin – Acinetobacter, antimicrobial resistance, pro-inflammatory immune response
- Dr Georgina Manning – Campylobacter, virulence and invasion, genomics
- Dr Samantha McLean – Antimicrobial, bacterial molecular biology, carbon monoxide, reactive small molecules, pathogens
- Dr Gareth McVicker – E. coli pathogenesis, plasmid stability, mobile genetic elements
- Dr Jody Winter – Helicobacter, bacterial membrane vesicles, immune modulation, pathogenesis
