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Group

Pathogen Research

Unit(s) of assessment: Allied Health Professions, Dentistry, Nursing and Pharmacy

Research theme: Health and Wellbeing

School: School of Science and Technology

Overview

Mechanisms of pathogenesis and evolution of virulence.

The Pathogen Research Group studies a range of organisms of importance to human health, including bacteria that cause severe infections in neonates (Cronobacter) and the elderly (drug resistant E. coli), as well as foodborne pathogens (Camyplobacter, Yersinia), and the protozoan Leishmania, an intracellular parasite causing around two million infections worldwide.

Our research is a mixture of classical bacterial genetics and pathogenesis research, in addition to population genetics and genomics to uncover mechanisms of pathogenesis and evolution of virulence. Using genomics we also analyse phage sequences to quantify polymorphism frequency in populations and thereby characterise evolution in experimental settings.

Skills/Techniques: next-generation genomics suite – MiSeq, Nanopore & associated kit; bacteria and phage culture including microaerobic, anaerobic & bioreactor; mammalian cell culture; direct droplet digital PCR; Galleria & tissue culture infection models; dual beam spectrophotometry; molecular biology, mutagenesis, recombinant protein purification and characterisation, systems biology.

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