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Gemma Foulds

Research Fellow

School of Science & Technology

Role

Dr Foulds is a Research Fellow in the John van Geest Cancer Research Centre.

Career overview

Dr Foulds gained her BSc Biology (Hons) degree from York University in 2005 and began working as a Research Technician in the Immunobiology Research Group at University of Sheffield in 2006. She worked on a Foods Standard Agency funded project investigating links between nutritional status and immune function in older adults, as well running a trial examining the effect of pre- and/or pro-biotic supplementation sufferers of IBS. Later her research focus shifted to immunology in cancer and she obtained a PhD for her research into the use of membrane-bound heat shock protein 70 (memHsp70) as a target for imaging and immunotherapy in breast cancer.

Dr Foulds joined Nottingham Trent University as a Research Fellow in 2013 investigating the immune-phenotype of patients with breast and prostate cancer. In 2018 she began working on an NIHR-funded, multi-centre phase II clinical trial monitoring immune system reconstitution in patients with Crohns Disease undergoing autologous stem cell transplantation (ASTIClite trial).

Research areas

Dr Foulds' main research interest lies in immune monitoring. She has previously worked on projects investigating potential links between the immune-phenotype and prognosis/disease status of patients with prostate and breast cancer. She currently works as part of an NIHR-funded phase II clinical trial investigating the use of autologous stem cell transplant in patients with Crohn's disease. She is responsible for co-ordinating and processing samples from patients taking part in the trial around the country; monitoring their immune system before and during their treatment to help gain a better understanding of the disease.

Dr Foulds also has a strong interest in imaging techniques, in particular multi-colour Flow Cytometry. She has over ten years experience working with numerous different instruments and designing experiments. She has presented at an international flow cytometry conference and is keen to keep up-to-date with advances in the field.

Publications

Recent publications:

Hood SP, Foulds GA, Imrie H, Reeder S, McArdle SEB, Khan M, Pockley AG. 2019. Phenotype and function of activated natural killer cells from patients with prostate cancer: Patient-dependent responses to priming and IL-2 activation. Frontiers in Immunology, doi:10.3389/fimmu.2018.03169

Dring KJ, Cooper SB, Morris JG, Sunderland C, Foulds GA, Pockley AG, Nevill ME. 2018. Cytokine, glycemic and insulinemic responses to an acute bout of games-based activity in adolescents. Scandinavian Journal of Medicine and Science in Sports, doi:10.1111/sms.13378

Multhoff G, Breuninger S, Stangl S, Werner C, Sievert W, Lobinger D, Foulds GA, Wagner S, Pickhard A, Pointek G, Pockley AG. 2018. Membrane Hsp70 – a novel target for the isolation of circulating tumour cells after epithelial-to-mesenchymal transition. Frontiers in Oncology, 8:497

Foulds GA, Vadakekolathu J, Abdel-Fatah TMA, Nagarajan D, Reeder S, Johnson C, Hood S, Moseley PM, Chan SYT, Pockley AG, Rutella S, McArdle SEB. 2018. Immune-phenotyping and transcriptomic profiling of peripheral blood mononuclear cells from patients with breast cancer: Identification of a 3 gene signature which predicts relapse of triple negative breast cancer. Frontiers in Immunology, 9:2028.

Pockley AG, Lindsay JO, Foulds GA, Rutella S, Gribben JG, Alexander T, Snowden JA. 2018. Immune reconstitution after autologous hematopoietic stem cell transplantation in Crohn’s disease: Current status and future directions. A review on behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation in Refractory CD-Low Intensity Therapy Evaluation Study investigators. Frontiers in Immunology, 9:646.

Stangl S, Foulds GA, Fellinger H, Pilkington GJ, Pockley AG, Multhoff G. 2018. Immunohistochemical and flow cytometric analysis of intracellular and membrane-bound Hsp70, as a putative biomarker of glioblastoma multiforme, using the cmHsp70.1 monoclonal antibody. Methods in Molecular Biology, 1709: 307-320.

Cosma G, McArdle SE, Reeder S, Foulds GA, Hood S, Khan M, Pockley AG. 2017. Identifying the presence of prostate cancer in individuals with PSA levels <20ng mL-1 using computational data extraction analysis of high dimensional peripheral blood flow cytometric phenotyping data. Frontiers in Immunology. 8: 1771.

Cossarizza A, Chang HD, Radbruch A, + 228 authors (2017). Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology, 47: 1584-1797.

Pockley AG, Foulds GA, Oughton JA, Kerkyliet NI, Multhoff G. 2015. Immune cell phenotyping using flow cytometry. Curr Protoc Toxicol 66:18.8.1-34.

Foulds GA, Gehrmann M, Stangl S, Oellinger R, Breuninger S, Rad R, Pockley AG, Multhoff G. 2014. Tumour imaging and targeting potential of an Hsp70-derived 14-mer peptide. PLoS One 9(8): e10534