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John Dickenson

Lecturer/Senior Lecturer

School of Science & Technology

Staff Group(s)
Bioscience

Role

Dr John Dickenson teaches on a range of undergraduate and postgraduate modules and is course leader for the part-time Biological Sciences degree programme. He teaches on the following modules:

  • BIOL 10302 Human Physiology
  • BIOL 14403 Forensic Biology and Microscopy
  • BIOL 22141 Chemotherapy of Cancer and Infections
  • BIOL 22111 Pathophysiology and Pharmacology of Cells and Tissues
  • BIOL 33141 Current Topics in Physiology
  • BIOL 33151 Current Topics in Pharmacology
  • BIOL 40093 Pharmacology
  • BIOL 40013 Biology of Disease
  • BIOL 40032 Cell Culture and Antibody Technology
  • BIOL 40381 Cancer and Heart Disease

Research areas

Dr Dickenson's research interests are as follows:

  • G-protein coupled receptor signalling

Identifying novel cell signalling mechanisms that are activated by members of the G-protein coupled receptor superfamily in particularly the adenosine A1 receptor. Recent work has focused on the signalling mechanisms associated with adenosine A1 receptor-mediated cardioprotection and the modulation of transglutaminase 2.

  • The cardioprotective mechanisms of flavonoids

This new avenue of research is investigating the signalling mechanisms triggered by flavonoids. These compounds are widely found in fruits, vegetables, nuts, seeds, flowers and other plant matter and as such they are an integral part of the human diet. The effects of these compounds are being explored using cardiomyocytes exposed to oxidative stress and / or hypoxia / re-oxygenation with the aim of identifying novel signalling mechanisms.

  • The cardiotoxicity of organophosphates

This project is concerned with investigating the effects of organophosphates on cardiomyocytes using both established cell lines and cardiomyocytes derived from cord blood as model systems.

Opportunities to carry out postgraduate research towards an MPhil / PhD exist and further information may be obtained from the NTU Graduate School.

Publications

Selected publications

  • Phenyl saligenin phosphate induced caspase-3 and c-Jun N-terminal kinase activation in cardiomyocyte-like cells. Felemban SG, Garner A, Smida FA, Boocock DJ, Hargreaves AJ and Dickenson JM, Chemical Research in Toxicology, 2015, 28, 2179-2191
  • Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated H9c2 cardiomyocytes. Daubney J, Bonner PL, Hargreaves AJ and Dickenson JM, Basic and Clinical Pharmacology and Toxicology, 2015, 116, 96-109
  • Modulation of transglutaminase 2 activity in H9c2 cells by PKC and PKA signalling: a role for transglutaminase 2 in cytoprotection. Almami I, Dickenson JM, Hargreaves AJ and Bonner PLR, British Journal of Pharmacology, 2014, 171, 3946-3960
  • The MPTP status during early reoxygenation is critical for cardioprotection. Husainy MA, Dickenson JM and Galiñanes M Journal of Surgical Research, 2012, 174, 62-72
  • Role of large-conductance Ca2+-activated K+ channels in adenosine A1 receptor-mediated pharmacological postconditioning in H9c2 cells. Fretwell L and Dickenson JM, Canadian Journal of Physiology and Pharmacology 2011, 89, 24-30
  • Selective blockade of protein kinase B protects the rat and human myocardium against ischaemic injury. Linares-Palomino J, Husainy MA, Lai VK, Dickenson JM and Galiñanes M, Journal of Physiology, 2010, 588, 2173-2191
  • Role of large-conductance Ca2+-activated potassium channels in adenosine A1 receptor-mediated pharmacological preconditioning in H9c2 cells. Fretwell L and Dickenson JM, European Journal of Pharmacology, 2009, 618, 37-44
  • Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts. Talasila A, Germack R and Dickenson JM, British Journal of Pharmacology, 2009, 158, 339-353

For full list click 'Go to John Dickenson's publications' link above.

See all of John Dickenson's publications...