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John Dickenson

Senior Lecturer

School of Science & Technology

Staff Group(s)
Bioscience

Role

Dr John Dickenson teaches on a range of undergraduate and postgraduate modules and is course leader for the part-time Biological Sciences degree programme. He teaches on the following modules:

  • BIOL 10302 Human Physiology and BIOL 14410 Human Physiology (Apprentice)
  • BIOL 22141 Chemotherapy of Cancer and Infections
  • BIOL 22111 and BIOL 24413 Pathopharmacology
  • BIOL 22171 Professional Skills in Pharmacology
  • BIOL 33141 Current Topics in Physiology
  • BIOL 33151 Current Topics in Pharmacology
  • BIOL 30001/2 Honours Research Project
  • BIOL 40093 Pharmacology
  • BIOL 40291 Pharmacology (ELearn)
  • BIOL 40013 Biology of Disease
  • BIOL 40381 Cancer and Heart Disease
  • BIOL 40331 Cell Culture and Antibody Technology (ELearn)
  • BIOL 40111 Research Project

Career overview

1990-1998: University of Nottingham (Post-doctoral Research Fellow)

1998 - present Nottingham Trent University (Senior Lecturer in Molecular Pharmacology)

Research areas

Dr Dickenson's research interests are as follows:

  • G-protein coupled receptor signalling

Identifying novel cell signalling mechanisms that are activated by members of the G-protein coupled receptor superfamily in particularly the adenosine A1 receptor. Recent work has focused on the signalling mechanisms associated with adenosine A1 receptor-mediated cardioprotection and the modulation of transglutaminase 2.

  • The cardioprotective mechanisms of flavonoids

This new avenue of research is investigating the signalling mechanisms triggered by flavonoids. These compounds are widely found in fruits, vegetables, nuts, seeds, flowers and other plant matter and as such they are an integral part of the human diet. The effects of these compounds are being explored using cardiomyocytes exposed to oxidative stress and / or hypoxia / re-oxygenation with the aim of identifying novel signalling mechanisms.

  • The cardiotoxicity of organophosphates

This project is concerned with investigating the effects of organophosphates on cardiomyocytes using both established cell lines and cardiomyocytes derived from cord blood as model systems.

Opportunities to carry out postgraduate research towards an MPhil / PhD exist and further information may be obtained from the NTU Graduate School.

Publications

Selected publications

  • Ebegboni VJ, Balahmar RM, Dickenson JM and  Sivasubramaniam SD (2019) The effects of flavonoids on human first trimester trophoblast spheroidal stem cell self-renewal, invasion and JNK/p38 MAPK activation: Understanding the cytoprotective effects of these phytonutrients against oxidative stress. Biochem. Pharmacol. 164: 289-298.
  • Ebegboni VJ, Dickenson JM and Sivasubramaniam SD (2019) Antioxidative effects of flavonoids and their metabolites against hypoxia reoxygenation-induced oxidative stress in a human first trimester trophoblast cell line. Food Chem. 272: 117-125.
  • Algarni AS, Hargreaves AJ and Dickenson JM (2018) Activation of transglutaminase 2 by nerve growth factor in differentiating neuroblastoma cells: a role in cell survival and neurite outgrowth. Eur. J. Pharmacol. 820: 113-129.
  • Vyas FS, Nelson CP and Dickenson JM (2018) Role of transglutaminase 2 in A1 adenosine receptor- and β2-adrenoceptor-mediated pharmacological pre- and post-conditioning against hypoxia-reoxygenation-induced cell death in H9c2 cells. Eur. J. Pharmacol. 819: 144-160.
  • Vyas FS, Nelson CP, Freeman F, Boocock DJ, Hargreaves AJ and Dickenson JM (2017) β2-adrenoceptor-induced modulation of transglutaminase 2 transamidase activity in cardiomyoblasts. Eur. J. Pharmacol. 813: 105-121.
  • Algarni AS, Hargreaves AJ and Dickenson JM (2017) Role of transglutaminase 2 in PAC1 receptor mediated protection against hypoxia-induced cell death and neurite outgrowth in differentiating N2a neuroblastoma cells. Biochem. Pharmacol. 128: 55-73.
  • Vyas FS, Hargreaves AJ, Bonner PLR, Boocock DJ, Coveney C and Dickenson JM (2016) A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: a role in cell survival. Biochem. Pharmacol. 107: 41-58.
  • Felemban SG, A.C. Garner, Smida FA, Boocock DJ, Hargreaves AJ and Dickenson JM (2015) Phenyl saligenin phosphate induced caspase-3 and c-Jun N-terminal kinase activation in cardiomyocyte-like cells. Chem. Res. Toxicol. 28: 2179-2191.
  • Daubney J, Bonner PL, Hargreaves AJ and  Dickenson JM (2015) Cardioprotective and cardiotoxic effects of quercetin and two of its in vivo metabolites on differentiated H9c2 cardiomyocytes. Basic. Clin. Pharmacol. Toxicol. 116: 96-109.

For full list click 'Go to John Dickenson's publications' link above.

See all of John Dickenson's publications...