Dr Ugun- Klusek is a Research Fellow in Cell Biology. She also acts as a representative for Research Fellows and Associates in the School of Science and Technology.
Dr Ugun- Klusek is a member of Professor Ellen Billet's research team. Her research interests are involvement of enzyme monoamine oxidase in cell death / survival mechanisms and neurodegeneration. In addition she is interested in the application of proteomics techniques to study disease mechanisms
Sponsors and collaborators
Current and recent research is being conducted with the collaboration of:
- Dr L Bedford, Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK
- Dr Christoph Ufer, Institute of Biochemistry, Universitatsklinikum Charite, Berlin, Germany
- Dr J Fitzgerald, Functional Neurogenomics Laboratory, Hertie-Institute for Clinical Brain Research, Tübingen, Germany
Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins. Fitzgerald JC, Ugun-Klusek A, Allen G, De Girolamo LA, Hargreaves I, Ufer C, Abramov AY and Billett EE, The FASEB Journal, 2013, doi:10.1096/fj.13-235481 (e-pub ahead of print)
Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones. Elkharaz J, Ugun-Klusek A, Constantin-Teodosiu T, Lawler K, Mayer RJ, Billett E, Lowe J, Bedford L, Biochim Biophys Acta. 2013, 1832 (12), 1930-1938
Reduced placental vascular reactivity to 5-hydroxytryptamine in pre-eclampsia and the status of 5HT2A receptors. Ugun-Klusek A, Tamang A, Loughna P, Billett E, Buckley G and Sivasubramaniam S, Vascular Pharmacology, 2011, 55 (5-6), 157-162
Monoamine oxidase a expression is vital for embryonic brain development by modulating developmental apoptosis.Wang CC, Borchert A, Ugun-Klusek A, Tang LY, Lui WT, Chu CY, Billett E, Kuhn H and Ufer C, The Journal of Biological Chemistry, 2011, 286 (32), 28322–28330See all of Aslihan Ugun Klusek's publications...