Carl_Nelson

Carl Nelson

Lecturer/Senior Lecturer

School of Science & Technology

Staff Group(s)
Bioscience

Role

Dr Nelson is the Pathway Leader for the Physiology & Pharmacology pathway within the BSc (Hons) Biological Sciences degree. He is the Module Leader for:

  • Human Physiology
  • Physiology
  • Cell Biology
  • Physiology.

He also teaches on a variety of other Pharmacology-related modules.

Career overview

Previous to joining NTU, Dr Nelson was a Post-doctoral Research Fellow at the University of Nottingham and prior to that at the University of Leicester

Research areas

Dr Nelson's research background is in the field of cell signalling with a particular emphasis on G Protein-coupled receptors (GPCRs) and their downstream signalling pathways. Current research interests include the chronic effects of beta-adrenoceptor signalling in airway epithelial cells and the role of RNA-sensing toll-like receptors in the respiratory system (funded by The Physiological Society).

Opportunities to carry out postgraduate research towards an MPhil/PhD in the School of Science and Technology exist and further information may be obtained from the NTU Graduate School.

External activity

Dr Nelson has peer reviewed papers for international scientific journals including the British Journal of Pharmacology, Biochemical Pharmacology, and the Journal of Pharmacology and Experimental Therapeutics.

Dr Nelson is a member of the British Pharmacological Society, The Biochemical Society and The Physiological Society.

Sponsors and collaborators

Aspects of Dr Nelson's current research are performed in collaboration with Professor Ian Hall and Dr Ian Sayers (University of Nottingham).

Publications

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension. Willets JM, Nash CA, Rainbow RD, Nelson CP, Challiss RJ, American Journal of Physiology Cell Physiology, 2015, 309 (3) 179-89

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B. Brignell JL, Perry MD, Nelson CP, Willets JM, Challiss RAJ and Davies NW, PLoS One, 2015, 10 (3) e0121285

Ca2+ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting. Koopmans T, Anaparti V, Castro-Piedras I, Yarova P, Irechukwu N, Nelson C, Perez-Zoghbi J, Tan X, Ward JPT, Wright DB, Pulmonary Pharmacology and Therapeutics, 2014, 29 (2), 108-20

GSTCD and INTS12 Regulation and Expression in the Human Lung. *Obeidat M, *Miller S, Probert K, Billington CK, Henry A, Hodge E, Nelson CP, Stewart CE, Swan C, Wain LV, Melén E, Ushey K, Hao K, Lamontagne M, Bossé Y, Postma DS, Tobin MD, Sayers I and Hall IP, PLOS One, 2013, 8 (9), e74630

HTR4 gene structure and altered expression in the developing lung. Respiratory Research. *Hodge E, *Nelson CP, *Miller S, Billington CK, Stewart CE, Swan C, Malarstig A, Henry AP, Gowland C, Melén E, Hall IP and Sayers I, 2013, 14, 77

Principal role of the type 6 adenylate cyclase in K+-channel regulation and vasodilator signalling in vascular smooth muscle cells. Nelson CP, Rainbow RD, Brignell JL, Perry MD, Willets, JM, Davies NW, Standen NB and Challiss RAJ, Cardiovascular Research, 2011, 91 (4), 694-702

G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling. Morris GE, Nelson CP, Everitt D, Brighton PJ, Standen NB, Challiss RAJ and Willets JM, Cardiovascular Research, 2011, 89 (1), 193-203

Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2. Morris GE, Nelson CP, Standen NB, Challiss RAJ and Willets JM, Cardiovascular Research, 2010, 85 (3), 424-33

* authors contributed equally

See all of Carl Nelson's publications...

Press expertise

  • G protein-coupled receptors
  • Calcium signalling in smooth muscle
  • Cyclic AMP signalling
  • RNA-sensing toll-like receptors