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Cheuk-Wing LI

Cheuk-Wing Li

Senior Lecturer

School of Science & Technology

Role

Wing Li is a Senior Lecturer of Analytical Chemistry in the School of Science and Technology.  He is the Module Leader for Advanced Chemistry and Advanced Chemical Analysis.  He teaches on the following modules:

  • CHEM10191 Intro to Analytical Chemistry
  • CHEM10211 Intro to Forensic Analysis
  • CHEM20551 Analytical Chemistry
  • CHEM30306 Advanced Chemical Analysis
  • CHEM30310 Advanced Chemistry
  • CHEM19001 Chemistry Yr1 Tutorial Module
  • CHEM29001 Chemistry Yr2 Tutorial Module

Career overview

Senior Lecturer, Nottingham Trent University, UK (2018-present)

Assistant Professor, University of Macau, Macau (2011-2018)

Research Fellow, City University of Hong Kong, Hong Kong (2009-2011)

Postdoctoral Scholar, Stanford University, USA (2007-2009)

Research areas

Dr. Li has been working in the field of biochip technology for over 18 years.  His research interests are focused on the development of low-cost biochip fabrication methods and the application of biochip technology in cell-based assays and high-throughput drug screening using microorganisms such as zebrafishes.

External activity

Member of Royal Society of Chemistry

Prizes/Awards:

  • 2019    Diplôme pour I’invention: “Dispositif d'imagerie motorisé pour le criblage à haut débit des poissons zèbres”, Salon International Des Inventions, Genève
  • 2017    Merit Award in the “2017 Cross Straits, Hong Kong and Macau Collaborative Innovation Road Show Competition”, Macau
  • 2016    The State Natural Science Award, the second class, China

Sponsors and collaborators

Recent research is being carried out in collaboration with, or funded by:

Funding supported by the University of Macau

  • Enhanced mixing and debris filter for the analysis of herbal extracts in microfluidic chips, SRG012_ICMS12_LCW (2011-2012)
  • Optimizing concentration ratio among tetrandrine and anticancer drugs on a microfluidic platform for the study of synergistic anticancer effects against multi-drug resistance leukemia cells, MYRG043(Y1-L1)-ICMS12-LCW (2012-2014)
  • Development of a Fully Automated Biochip Platform for the Study of Tradition Medicine, MYRG108(Y1-L2)-ICMS13-LCW (2013-2016)
  • Large scale screening platform for zebrafish with posture adjustment microwells, MYRG2017-00112-ICMS (2018-2019)

Funding supported by Macau government

  • Measurement of rate constants of receptor-ligand binding on an automated microfluidic chip, FDCT/042/2016/A (2017-2018)

Publications

REFEREED JOURNAL AND ARTICLES:

45

Zhang, Y., Li, C.-W., Zhou, L., Chen, Z., Yi, C. "“Plug and Play” logic gate construction based on chemically triggered fluorescence switching of gold nanoparticles conjugated with Cy3-tagged aptamer" Microchimica Acta (2020) 187(8), 437.

44

Ma, J.; Yi, C.Q.*; Li, C.-W.* "Facile synthesis and functionalization of color-tunable Ln3+-doped KGdF4 nanoparticles on a microfluidic platform" Materials Science & Engineering C-Materials for Biological Applications (2020) 108, 110381.

43

Xu, T.; Fu, H.Y.; Li, Y.P.; Chen, X.M.; Cheuk, W.; Li, C.-W.; Zou, H.; Yue, W.Q.; Au, S.-K.; Yang, M.S.* "Single cell target gene mutation analysis by arc-edge-channel monolithic valve microfluidic cell isolation and locked nucleic acid based PCR detection" Sensors & Actuators: B. Chemical (2019) 293, 224-234.

42

M. K.  Alam; E. Koomson; H. Zou; C.Q. Yi; Li C.-W.; T. Xu; M.S. Yang "Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007-2017)" Analytica Chimica Acta (2018) 1044, 29-65.

41

Chen, W.D.; Wang, Q.; Ma, J.P.; Li, C.-W.; Yang, M.; Yi, C.Q.* "A ratiometric fluorescent core-shell nanoprobe for sensing and imaging of zinc(II) in living cell and zebrafish" Microchimica Acta (2018) 185(11), 523.

40

Yu, G. D.; Lee, S. M. Y.; Li, C.-W.* "Studying the Time Course of Cardiac Responses of the Same Zebrafish using Scalable Fish-dock Microarchitecture" Sensors & Actuators: B. Chemical (2018) 268, 245-254.

39

Ma, J.; Li, C.-W.* "Rapid and Continuous Parametric Screening for the Synthesis of Gold Nanocrystals with Different Morphologies by a Microfluidic Device" Sensors & Actuators: B. Chemical (2018) 262, 236-244.

38

Gu, L.J.; Yu, G.D.; Li, C.-W.* "A Fast and Low-cost Microfabrication Approach for Six Types of Thermoplastic Substrates with Reduced Feature Size and Minimized Bulges using Sacrificial Layer Assisted Laser Engraving" Analytica Chimica Acta (2018) v997, 24-34.

37

Li, L; Liu,Z; Zhang, H; Yue, W; Li, C.-W.*; Yi, C. Q.* "A point-of-need enzyme linked aptamer assay for Mycobacterium tuberculosis detection using a smartphone" Sensors & Actuators: B. Chemical (2018) 254C, 337-346.

36

Li, C.-W.*; Zhu, Y.; Zhan, J.S.; Ma, J.; Gu, L.; Fang, Y.; Yi, C. Q.* "Separation of  Polystyrene  Nanoparticles in Polydimethylsiloxane  Microfluidic  Devices with a  Combined Titania and Sodium Dodecyl Sulfate Inner Coating" Microchimica Acta (2017), 184(7), 2227-2239.

35

Ma, J.; Lee, S. M. Y.; Yi, C. Q.*; Li, C.-W.* "Controllable Synthesis of Functional Nanoparticles by Microfluidic Platform for Biomedical Applications - A Review" Lab On A Chip (2017),17, 209-226.

34

Yi Pan, Shi, Y. P.; Chen, J.; Wong, C. M.; Zhang, H.; Li, M. J.; Li, C.-W.*,Yi, C. Q.* "Grafting Polyethylenimine with Quinoline Derivatives for Targeted Imaging of Intracellular Zn2+ and Logic Gate Operations" Materials Science & Engineering C-Materials for Biological Applications (2016), 69, 561-568.

33

Pan, Y.; Shi, Y. P.; Chen, J.;  Chen J.; Hou, M.; Chen, Z. P.; Li, C.-W., Yi, C. Q.* "Design of Multiple Logic Gates Based on Chemically Triggered Fluorescence Switching of Functionalized Polyethylenimine" ACS Applied Materials & Interfaces (2016), 8, 9472-9482

32

Ma, J.; Dong, H.*; Zhu, H. Y.; Li, C.-W., Li, Y. Y.*; Shi, D. "Deposition of gadolinium onto the shell structure of micelles for integrated magnetic resonance imaging and robust drug delivery systems" Journal of Materials Chemistry B (2016), 4, 6094-6102.

31

Yi, C. Q.; Liu, L.; Li, C.-W.; Zhang, J.C.; Yang, M. S.* "Synthesis, characterization and biomedical application of multifunctional luminomagnetic core–shell nanoparticles" Materials Science & Engineering C-Materials for Biological Applications (2015), 46, 32-40

30

Jiang, J. Y.; Zhan, J. S.; Yue, W. Q.; Yang, M. S.; Yi, C. Q.*; Li, C.-W.* "A Single Low-cost Microfabrication Approach for Polymethylmethacrylate, Polystyrene, Polycarbonate and Polysulfone Based Microdevices" RSC Advances. (2015), 5, 36036-36043

29

Shi, Y. P.; Chen, Z. H.; Cheng, X.; Pan, Y.; Zhang, H.; Zhang, Z. M.; Li, C.-W.; Yi, C. Q.*: A novel dual-emission ratiometric fluorescent nanoprobe for sensing and intracellular imaging of Zn2+. Biosensors & Bioelectronics (2014), 61, 397-403.

28

Li, C.-W.*; Yu, G. D.; Jiang, J. Y.; Lee, S. M. Y.; Yi, C. Q.; Yue, W. Q.; Yang, M. S.: A microfluidic linear node array for the study of protein-ligand interactions. Lab On A Chip (2014), 14, 3993-3999.

27

Yue, W. Q.; Zou, H.; Jin, Q. H.; Li, C.-W.; Xu, T.; Fu, H. Y.; Tzang, L. C. H.; Sun, H. Y.; Zhao, J. L.; Yang, M. S.*: Single layer linear array of microbeads for multiplexed analysis of DNA and proteins. Biosensors & Bioelectronics (2014), 54, 297-305.

26

Chong, C. M.; Shen, M. Y.; Zhou, Z. Y.; Pan, P. C.; Hoi, P. M.; Li, S.; Liang, W.; Ai, N. N.; Zhang, L. Q.; Li, C.-W.; Yu, H. D.; Hou, T. J.; Lee, S. M. Y.*: Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP+-induced oxidative stress and cell death in SH-SY5Y cells. Free Radical Biology and Medicine (2014), 74, 283-293.

25

Xu T.; Yue, W.Q.; Li, C.-W.; Yao, X. S.; Yang, M. S.* "Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells" Lab On A Chip (2013), 13, 1060-1069.

24

Li, C.-W.§; Yue, W. Q.§; (§ equal contribution) Xu, T.; Yang, M. S.* “Screen printing of solder resist as master substrates for fabrication of multi-level microfluidic channels and flask-shaped microstructures for cell-based applications” Biosensors & Bioelectronics (2013), 41, 675-683.

23

Zhang, H.§; Lian, L.§; (§ equal contribution) Li, C.-W.; Fu, H. Y.; Chen, Y.; Yang, M. S.* "Multienzyme-nanoparticles Amplification for Sensitive Virus Genotyping in Microfluidic Microbeads Array Using Au Nanoparticle Probes and Quantum Dots as Labels" Biosensors & Bioelectronics (2011), 29, 89-96

22

Li, C.-W.§; Yue, W. Q.§;(§ equal contribution) Xu, T.; Yang, M. S.* “Integrated sieving microstructures on microchannels for biological cell trapping and droplet formation” Lab On A Chip (2011), 11, 3352-3355

21

Chueh, B.-H.; Li, C.-W.; Wu. H.; Davsion, M.; Wei, H. B.; Bhaya, D.; Zare, R. N.* “Whole gene amplification and protein separation from a few cells” Analytical Biochemistry (2011), 411, 64-70.

20

Wei, H. B.; Chueh, B. H.; Wu, H. L.; Hall, E. W.; Li, C.-W.; Schirhagl, R.; Lin, J.-M.; Zare, R. N.* "Particle Sorting Using a Porous Membrane in a Microfluidic Device" Lab On A Chip (2011), 11, 238-245.

19

Li, M.-J.*, Jiao, P. C., He, W. W., Yi, C. Q., Li, C.-W., Chen, X., Chen G.-N.*, Yang M. S. "Water-soluble and Biocompatible Cyclometalated Iridium(III) Complexes: Synthesis, Luminescence and Sensing Application" European Journal of Inorganic Chemistry (2011), 2, 197-200.

18

Xu, T.; Yue, W. Q.; Li, C.-W.; Yao, X. S.; Cai, G. P.; Yang, M. S.* “Real-time monitoring of suspension cell-cell communication using an integrated microfluidics” Lab On A Chip (2010), 10, 2271-2278.

17

Yi, C. Q.; Li, C.-W.; Zhang, M. L.; Wong, N. B.; Lee, S. T.; Yang, M. S.* “Patterned growth of vertically aligned silicon nanowire arrays for label-free DNA detection using surface-enhanced Raman spectroscopy” Analytical and Bioanalytical Chemistry (2010), 397(7), 3143-3150.

16

Zhang, H.; Xu, T.; Li, C.-W.; Yang, M. S.* "A microfluidic device with microbead array for sensitive virus detection and genotyping using quantum dots as fluorescence labels" Biosensors & Bioelectronics (2010), 25, 2402-2407.

15

Xu, T.; Li, C.-W.; Yao, X. S.; Cai, G. P.; Yang, M. S.* “Microfluidic formation of single cell array for parallel analysis of CRAC channel activation and inhibition” Analytical Biochemistry (2010), 396, 173-179.

14

Li, C.-W.; Yang, M. S.* “3-D Streamline Steering by Nodes Arrayed in Entangled Microfluidic Network” Lab On A Chip (2007), 7, 1712-1716.

13

Li, C.-W.; Chen, R. S.; Yang, M. S.* “Generation of linear and non-linear concentration gradients along microfluidic channel by microtunnel controlled stepwise addition of sample solution” Lab On A Chip (2007), 7, 1371-1373.

12

Yang, M. S.*; Tsoi, P. Y.; Li, C.-W.; Zhao, J.-L. “Analysis of Interactions of Template/primer Duplexes with T7 DNA Polymerase by Oligonucleotide Microarray” Sensors & Actuators: B. Chemical (2006), 115(1), 428-433.

11

Yi, C. Q.; Zhang, Q.; Li, C.-W.; Yang, J.; Zhao, J.-L.; Yang, M. S.* “Optical and Electrochemical Detection Techniques for Cell-based Microfluidic Systems” Analytical and Bioanalytical Chemistry (2006), 384, 1259-1268.

10

Yi, C. Q.; Li, C.-W.; Jin, S. L.; Yang, M. S.* “Microfluidics Technology for Manipulation and Analysis of Biological Cells” Analytica Chimica Acta (2006), 560, 1-23.

9

Li, C.-W.; Yang, J.; Tzang, C. H.; Zhao, J.-L.; Yang, M. S.* “Using Thermally Printed Transparency as Photomasks to Generate Microfluidic Structures in PDMS Material” Sensors & Actuators: A. Physical (2006), 126, 463-468.

8

Li, C.-W.; Yang, J.; Yang, M. S.* “Dose-dependent Cell-based Assays in V-shaped Microfluidic Channels” Lab On A Chip (2006), 6, 921-929.

7

Yang, M. S.*; Tsoi, P. Y.; Li, C.-W.; Woo, S. H.; Zhao, J.-L.; Yam, W. C. “Detection of Mutations in RNA Polymerase Beta Subunit Gene Encoding Resistance to Rifampin in Mycobacterium Tuberculosis by DNA Microarray” Analytical Letters (2005), 38(13), 2117-2134.

6

Tzang, C. H.; Li, C.-W.; Zhao, J.-L.; Yang, M. S.*; “Electrocatalytic Phenol Oxidation on Mixed Pt-RuO2 Nanoparticle Modified Electrode” Analytical Letters (2005), 38(11), 1735-1746.

5

Yang, J.; Li, C.-W.; Yang, M. S.* “Hydrodynamic Simulation of Cell Docking in Microfluidic Channels with Different Dam Structures” Lab On A Chip (2004), 4(1), 53-59.

4

Li, C.-W.; Cheung, C. N.; Yang, J.; Tzang, C. H.; Yang, M. S.* “PDMS-based Microfluidic Device with Multi-height Structures Fabricated by Single-step Photolithography using Printed Circuit Board as Masters” Analyst (2003), 128(9), 1137-1142.

3

Yang, J.; Li, C.-W.; Yang, M. S.* “Lab-on-a-chip (Microfluidics) technology” Acta Biochimica Et Biophysica Sinica (2002), 34(2), 117-123.

2

Yang, M. S.*; Li, C.-W.; Yang, J. “Cell Docking and On-chip Monitoring of Cellular Reactions with Controlled Concentration Gradient on a Microfluidic Device” Analytical Chemistry (2002), 74(16), 3991-4001.

1

Yang, M. S.*; Yang, J.; Li, C.-W.; Zhao, J.-L. “Generation of Concentration Gradient by Diffusive mixing and Consecutive Dilution in a Microfluidic Chip” Lab On A Chip (2002), 2(3), 158-163.

PATENTS

13

Li, C.-W.; Lee, S. M. Y.; Yu, G. D.; “Large-scale living organism screening system based on microfluidic technology” PRC Patent No.: 201710093950.7

12

Li, C.-W.; Yu, G. D.; Lee, S. M. Y.; An automated whole organism screening system.  US Patent Application Number: 62419489

11

Li, C.-W.; Yu, G. D.; Jiang, J. Y.; Lee, S. M. Y.; Microfluidics Separation Method and System Thereof.  (2017) US Patent No: 9,623,408

10

Yue, Z. F.; Li, C.-W.; Yi, C. Q.; Shaw, L.L. “A method for generating a concentration gradient by bridge-shaped microfluidic chip” (2013), PRC Patent No.: ZL201220259595.9

9

Li, C.-W.; Yi, C. Q.; Shaw, L.L.; Yue, Z. F. “A parallel microchip architecture for high-throughput bioassays” (2013), PRC Patent No.: ZL201220259439.2

8

Yue, Z. F.; Li, C.-W.; Yi, C. Q.; Ouyang, S.; Shaw, L.L.; Chen, J. C. “Method to control the quality and quantity of biological cell immobilization in a microdevice” (2013), PRC Patent No.: ZL201220381016.8

7

Li, C.-W.; Yi, C. Q.; Yue, Z. F.; Ouyang, S.; Shaw, L.L.; Chen, J. C. “A microfluidic architecture for the immobilization of biological cells” (2013), PRC Patent No.: ZL201220380831.2

6

Yue, Z. F.; Li, C.-W.; Ouyang, S.; Shaw, L.L.; Yi, C. Q. Chen, J. C. “A microstructure for the immobilization of particle entities and biological cells” (2012), PRC Patent No.: ZL201120255019.2

5

Li, C.-W.; Yi, C. Q.; Shaw, L.L.; Yue, Z. F. “A microstructure for the generation and dispensing of consecutive concentration gradient” (2012), PRC Patent No.: ZL 2011 2 0253535. 1

4

Yang, M. S.; Li, C.-W.; Yang, J. “Apparatus and Methods for On-chip Monitoring of Cellular Reactions” (2009), US Patent No.: 7,560,267.

3

Yang, M. S.; Li, C.-W.; “Method and apparatus for exposing cells to different concentrations of analytes or drugs (2006), US Patent Application Number 11/489849

2

Yang, M. S.; Li, C.-W. “Portable CCD Based Imager for Microfluidic Device” (2006), PRC Patent No.: ZL200420110784.5.

1

Yang, M. S.; Li, C.-W. “Apparatus and Methods for On-chip Monitoring of Cellular Reactions” (2003), PRC Patent No.: ZL03120720.0.

Course(s) I teach on

  • Student using tablet in science lab
    Undergraduate | Full-time / Sandwich | 2020

    https://www.ntu.ac.uk/study-and-courses/courses/find-your-course/science-technology/ug/2020-21/bsc-chemistry