Lecturer / Senior Lecturer
Dr Colombo's main contributions to teaching at NTU are in the field of Biochemistry, Cell Biology and Clinical Biochemistry. Dr Colombo is Module leader for Clinical Biochemistry (Level Two) and also lectures in other undergraduate modules (e.g. Metabolism and its control, Level Two). Teaching and research interests include the regulation of central metabolism during cell proliferation, its role in epigenetics and, the mitochondrial function and the onset of pathology.
- Senior Research Postdoc- Wolfson Institute for Biomedical Research, University College London, London (2004-2013)
- Marie Curie EU Postdoc - GlaxoSmithKline, CEDD of Neurology, Harlow (2002-2004)
- Postdoc - Biological Sciences Department, Louisiana State University. Baton Rouge – Louisiana - USA. (1998-2002)
- Lecturer - Biological Chemistry Department, Faculty of Pharmacy and Biochemical Sciences, National University of Rosario, Rosario, Argentina (1993-1998)
- PhD- Faculty of Pharmacy and Biochemical Sciences, CEFOBI, National University of Rosario, Rosario, Argentina (1993-1998)
Dr Colombo’s current research interests are focused on the: 1) the mitochondrial role in the pathophysiology of diabetes, 2) the regulation of the central metabolism during cell cycle progression, and 3) the role of metabolism on the epigenetics of normal and pathological cells (including cancer).
Dr Colombo has also been involved in different research projects over his career, including:
- Role of Mitochondria as a signalling organelle
- Characterization of the endocannabionid system in model of Parkinson and Multiple sclerosis diseases
- Study of the CO2 concentrating mechanism of the photosynthetic algae Chlamydomonas
- Purification and characterization of PEP Carboxylase – NADP-Malic Enzyme from C4 plants.
For further details please visit Dr Sergio Colombo's Personal Page
Dr Colombo is an external grant evaluator of the following funding bodies (FONCyT, Argentina 2003-, Wellcome Trust 2008- and British Heart Foundation 2008-)
Sponsors and collaborators
Dr Colombo's research work has previously received sponsorship from the Wellcome Trust (2004-2007 and 2009-2011) and from a Postdoctoral Fellowship Marie Curie – FP6 (2002-2004).
Dr Colombo has collaborated with the following:
- Professor Sir Salvador Moncada – University College London
- Professor Jorge Erusalimsky – Cardiff Metropolitan University
- Professor Carlos Sanchez-Ferrer – Universidad Autónoma de Madrid, Spain
- Dr Concha Peiro – Universidad Autónoma de Madrid, Spain
- Dr Joel de Leon – University of Havana, La Havana, Cuba
- Dr James Moroney - Louisiana State University, Baton Rouge, USA
- Dr Carlos Andreo - The Center of Photosynthetic and Biochemical Studies, Rosario, Argentina.
Fulfilling the metabolic requirements for cell proliferation. Moncada S, Higgs A and Colombo SL, Biochemical Journal. 2012, 446, 1-7
Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. Colombo SL, Palacios-Callender M, Frakich N, Carcamo S, Kovacs I, Tudzarova S and Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108, 21069-21074
Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-ß-TrCP, regulate glycolysis during the cell cycle. Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH and Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108, 5278 5283
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes”, Colombo SL, Palacios-Callender M, Frakich N, De Leon J, Schmitt CA, Boorn L, Davis N, Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107, 18868-18873
AMPKa1 regulates the antioxidant defence of the vascular endothelial cells. Colombo SL and Moncada S, Biochemical Journal, Signal,2009, 421:163-169
Mitochondria As Signaling Organelles In The Vascular Endothelium. Quintero§ M, Colombo SL, Godfrey A and Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2006, 103, 5379-5384
Dopamine D2 and D3 receptor agonists protect oligodendrocytes against injury caused by glutamate oxidative stress and oxygen-glucose deprivation. Rosin C, Colombo SL, Calver A, Bates TE, Skaper SD, Glia, 2005, 52, 336-343
Rubisco Activase Is Required for Optimal Photosynthesis in the Green Alga Chlamydomonas reinhardtii in a Low-CO2 Atmosphere. Pollock§, Colombo SL, Davey L. Prout Jr., Ashley C. Godfrey, and James V. Moroney. Plant Physiology 2003, 133 (4), 1854-1861