Sergio Colombo

Sergio Colombo

Lecturer/Senior Lecturer

School of Science & Technology

Staff Group(s)
Bioscience

Role

Lecturer / Senior Lecturer

Dr Colombo's main contributions to teaching at NTU are in the field of Biochemistry, Cell Biology and Clinical Biochemistry. Dr Colombo is Module leader for Clinical Biochemistry (Level Two) and also lectures in other undergraduate modules (e.g. Metabolism and its control, Level Two). Teaching and research interests include the regulation of central metabolism during cell proliferation, its role in epigenetics and, the mitochondrial function and its role in the onset of pathology.

Career overview

Academic Career

  • Senior Research Postdoc- Wolfson Institute for Biomedical Research, University College London, London (2004-2013)
  • Marie Curie EU Postdoc - GlaxoSmithKline, CEDD of Neurology, Harlow (2002-2004)
  • Postdoc - Biological Sciences Department, Louisiana State University. Baton Rouge – Louisiana - USA. (1998-2002)
  • Lecturer - Biological Chemistry Department, Faculty of Pharmacy and Biochemical Sciences, National University of Rosario, Rosario, Argentina (1993-1998)
  • PhD- Faculty of Pharmacy and Biochemical Sciences, CEFOBI, National University of Rosario, Rosario, Argentina (1993-1998)

Research areas

Dr Colombo has been involved in different research projects over his career, including:

  • Role of Mitochondria as a signalling organelle
  • Characterization of the endocannabionid system in model of Parkinson and Multiple sclerosis diseases
  • Study of the CO2 concentrating mechanism of the photosynthetic algae Chlamydomonas
  • Purification and characterization of PEP Carboxylase – NADP-Malic Enzyme from C4 plants.

Dr Colombo’s current research interests are focused on the regulation of the central metabolism during cell cycle progression, its role in epigenetics and cancer and the mitochondrial role in pathophysiology.

Opportunities to carry out postgraduate research towards an MPhil / PhD exist in the School of Science and Technology and further information may be obtained from the NTU Graduate School.

External activity

Dr Colombo is an external grant evaluator of the following funding bodies (FONCyT, Argentina 2003-, Wellcome Trust 2008- and British Heart Foundation 2008-)

Sponsors and collaborators

Dr Colombo's research work has previously received sponsorship from the Wellcome Trust (2004-2007 and 2009-2011) and from a Postdoctoral Fellowship Marie Curie – FP6 (2002-2004).

Dr Colombo has collaborated with the following:

  • Professor Sir Salvador Moncada – University College London
  • Professor Jorge Erusalimsky – Cardiff Metroplitan University
  • Professor Carlos Sanchez-Ferrer – Universidad Autónoma de Madrid, Spain
  • Dr Concha Peiro – Universidad Autónoma de Madrid, Spain
  • Dr Joel de Leon – University of Havana, La Havana, Cuba
  • Dr James Moroney - Louisiana State University, Baton Rouge, USA
  • Dr Carlos Andreo - The Center of Photosynthetic and Biochemical Studies, Rosario, Argentina.

Publications

Fulfilling the metabolic requirements for cell proliferation. Moncada S, Higgs A and Colombo SL, Biochemical Journal. 2012, 446, 1-7

Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. Colombo SL, Palacios-Callender M, Frakich N, Carcamo S, Kovacs I, Tudzarova S and Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108, 21069-21074

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-ß-TrCP, regulate glycolysis during the cell cycle. Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH and Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108, 5278 5283

Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes”, Colombo SL, Palacios-Callender M, Frakich N, De Leon J, Schmitt CA, Boorn L, Davis N, Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107, 18868-18873

AMPKa1 regulates the antioxidant defence of the vascular endothelial cells. Colombo SL and Moncada S, Biochemical Journal, Signal,2009, 421:163-169

Mitochondria As Signaling Organelles In The Vascular Endothelium. Quintero§ M, Colombo SL, Godfrey A and Moncada S, Proceedings of the National Academy of Sciences of the United States of America, 2006, 103, 5379-5384

Dopamine D2 and D3 receptor agonists protect oligodendrocytes against injury caused by glutamate oxidative stress and oxygen-glucose deprivation. Rosin C, Colombo SL, Calver A, Bates TE, Skaper SD, Glia, 2005, 52, 336-343

Rubisco Activase Is Required for Optimal Photosynthesis in the Green Alga Chlamydomonas reinhardtii in a Low-CO2 Atmosphere. Pollock§, Colombo SL, Davey L. Prout Jr., Ashley C. Godfrey, and James V. Moroney. Plant Physiology 2003, 133 (4), 1854-1861

See all of Colombo, Sergio's publications...