Craig is a Senior Lecturer in Metabolic Health. His academic activities cover a broad range of teaching and research based contributions. Craig is interested in the basic mechanistic biology of both cells and tissue systems, working to apply this understanding towards treatment strategies targeting human diseases.
Prior to his career in academia, Craig was an analytical scientist working with 3M Health Care, Astra-Zeneca, Merck and Sanofi-Aventis. For his doctoral training Craig was located at the internationally renowned Roswell Park Cancer Institute, Buffalo, New York. Here he studied mechanisms of transcriptional control in endocrine cancers, employing epigenetic techniques and DNA methylation analysis. As a postdoctoral researcher, Craig trained within the fields of endocrinology and molecular metabolism at the Centre for Endocrinology Diabetes & Metabolism and the Institute of Metabolism & Systems Research at University of Birmingham. His work revealing the roles of tissue-specific glucocorticoid generation and its impacts upon tissues including brown adipose and skeletal muscle. These projects have helped define current understanding of endocrinology, metabolism and mitochondrial function.
Craig’s research niche focuses on the post-translational modification PARylation and the circadian supply of its rate-limiting cofactor NAD+. These are integral to whole-body physiology, with defects in their function impairing metabolic pathways within cells and the energy utilisation decisions by tissue systems.
Craig serves as an elected member on the Public Engagement Committee and the Early Career Steering Group for the Society for Endocrinology. He also is a member of the organising faculty and speaker for their annual Career Development Workshop.
Chortis VE, Richards AE, Doig CL, Walsh MA, Meimaridou E, Jenkinson C, Rodriguez-Blanco, Ronchi CL, Jafri A, Metherell LA, Hebenstreit D, Dunn WB, Arlt W, Foster PA. Nicotinamide nucleotide transporter: A novel target for adrenocortical cancer.
Endocrinology 2018; 1;159(8): 2836-2849 PMID:29850793
Fine N, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. A steroid-regulated feedback loop preserves insulin secretion in the face of perturbed beta cell function.
Diabetes 2018; 67(2): 278-290. PMID: 29203512
Doig CL, Fletcher RS, Morgan SA, McCabe EL, Larner DP, Tomlinson JW, Stewart PM, Philp A, Lavery GG. 11B-HSD1 modulates the set-point of brown adipose tissue response to glucocorticoids in male mice.
Endocrinology 2017; 158(6): 1964-1976. PMID: 28368470
Fletcher RS, Ratajczak J, Doig CL, Oakey LA, Callingham R, Da Silva Xavier G, Garten A, Elhassan YS, Redpath P, Migaud ME, Philp A, Brenner C, Canto C, Lavery GG. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle.
Molecular Metabolism 2017; 6(8): 819-832. PMID 28752046
Zielinska AE, Fletcher RS, Sherlock M, Doig CL & Lavery GG. Genetic manipulation of 11B-HSD1 and H6PDH activity in skeletal muscle.
Cell Biochemistry and Function 2017; 35(5) :269-277. PMID: 28749080
Doig CL & Lavery GG. PARP Inhibitors: Staying on Target?
Cell Chemical Biology 2016; 23(12): 1442-1443. PMID: 28009975
Doig CL, Battaglia S, Khanim FL, Bunce CM, Campbell MJ. Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells.
J Steroid Biochem Mol Biol. 2016; 155(Pt A):45-55. PMID: 26429394
Morgan SA, Hassan-Smith Z, Doig CL, Sherlock M, Stewart PM, Lavery GG. Glucocorticoids and 11B-HSD1 are major regulators of intramyocellular protein metabolism.
Journal of Endocrinology 2016; 229(3): 277-86. PMID: 27048233
Hardy RS, Doig CL, Hussain Z, O'Leary M, Morgan SA, Pearson MJ, Naylor A, Jones SW, Filer A, Stewart PM, Buckley CD, Lavery GG, Cooper MS, Raza K. 11B-Hydroxysteroid Dehydrogenase 1 within muscle protects against the adverse effects of local inflammation.
Journal of Pathology 2016; 240(4): 472-483. PMID: 27578244
Larner D, Morgan, SA, Gathercole LL, Doig CL, Guest P, Weston C, Hazeldine J, Tomlinson JW, Stewart PM, Lavery GG. Extra-hepatic 11B-HSD1 activity restrains inflammatory responses to diet-induced non-alcoholic fatty liver disease in male mice.
Endocrinology 2016; 157(9): 3493-504. PMID: 27384305
Doig CL, Bashir J, Zielinska AE, Cooper MS, Stewart PM, Lavery GG. TNFα mediated HSD11B1 binding of NF-κB p65 is associated with suppression of 11β-HSD1 in muscle.
Journal of Endocrinology 2014; 220(3): 389-96. PMID:24413729
Doig CL, Singh PK, Dhiman VK, Thorne JL, Battaglia S, Sobolewski M, Maguire O, O'Neill LP, Turner BM, McCabe CJ, Smiraglia DJ, Campbell MJ. Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns.
Carcinogenesis 2013; 34(2):284-56. PMID: 23087083
Singh PK, Doig CL, Dhiman VK, Turner BM, Smiraglia DJ, Campbell MJ. Epigenetic distortion to VDR transcriptional regulation in prostate cancer.
J Steroid Biochem Mol Biol. 2013; 136:258-63. PMID: 23098689
Ahmed A, Rabbitt E, Brady T, Brown C, Guest P, Bujalska IJ, Doig C, Newsome PN, Hubscher S, Elias E, Adams DH, Tomlinson JW, Stewart PM. A switch in hepatic cortisol metabolism across the spectrum of NAFLD.
PLoS One 2012; 7(2):e29531. PMID: 22363403
Thorne JL, Maguire O, Doig CL, Battaglia S, Fehr L, Sucheston LE, Heinaniemi M, O'Neill LP, McCabe CJ, Turner BM, Carlberg C, Campbell MJ. Epigenetic control of a VDR-governed feed-forward loop that regulates p21 expression and function in non-malignant prostate cells.
Nucleic Acids Research 2011; 29(6):2045-56. PMID: 21088000
Battaglia S, Maguire O, Thorne JL, Hornung LB, Doig CL, Liu S, Sucheston LE, Bianchi A, Khanim FL, Gommersall LM, Coulter HS, Rakha S, Giddings I, O'Neill LP, Cooper CS, McCabe CJ, Bunce CM, Campbell MJ. Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion.
Carcinogenesis 2010; 31(9):1650-60. PMID: 20466759
Watkins RJ, Read ML, Smith VE, Sharma N, Reynolds GM, Buckley L, Doig C, Campbell MJ, Lewy G, Eggo MC, Loubiere LS, Franklyn JA, Boelaert K, McCabe CJ. Pituitary tumor transforming gene binding factor: a new gene in breast cancer.
Cancer Research 2010; 70(9):3739-49. PMID: 20406982
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