Gareth Cave

Gareth Cave

Principal Lecturer

School of Science & Technology

Staff Group(s)
Chemistry and Forensic Science

Role

Dr Cave teaches on the following modules:

  • Inorganic Chemistry
  • Skills for Chemistry
  • Chemistry of Modern Day Materials
  • Advanced Techniques
  • Green Chemistry
  • Projects
  • Research Methodology
  • Dissertations
  • Metabolomics and Drug Design.

He is also Library Liaison, Disabilities Liaison Tutor and Chemistry Year One course tutor.

Research areas

Dr Cave's main areas of interest are:

  • Therapeutic transport devices
  • MRI / NMR contrast agents
  • Supramolecular chemistry
  • Green chemistry - with emphasis on physical-life sciences interface.

Investigations are in three interlinked areas:

  • Supramolecular chemistryUtilising non-covalent intermolecular bonding interactions (i.e. hydrogen-bonding, van der Waals forces, coordinate bonds, hydrophobic-hydrophobic, charge transfer interactions, etc.) facilitates the synthesis of large molecular architectures via a self-assembly mechanism. Thereby, enabling the development of discrete nanometre scale molecular capsules and tubes; capable of encapsulating and protecting a variety of guest molecules.
  • Transport vehiclesThe aforementioned supramolecular capsules and tubes are designed with readily accessible surface modifiers incorporated into their structures to allow multi-component functionality (e.g. attachment of hydrophobic / hydrophilic groups, biodegradable linkers, gene and peptide sequence, novel excipients, MRI tracers, pH and UV responsive systems, etc.). The molecular recognition and self-healing properties of these nano-materials allows them to reversibly transport a variety of multi-component guest materials (e.g. drug, gene sequence, peptide, ligand, gases, etc) as "unimolecular micelles" or prodrugs.
  • Green chemistryThis is the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances. Conventional methods used throughout organic synthesis involve the use of volatile organic solvents and often have low atom efficiency. Our research in this area looks to benign alternatives to VOC’s (e.g. ionic liquids, supercritical fluids, PPG) or indeed removing solvents altogether.

Other research areas:

  • Green chemistry (sustainable technologies)
  • MRI contrast agents
  • Nanometre scale drug / therapeutic delivery
  • Nano partials
  • Crystal engineering
  • X-Ray crystallography
  • Organometallic chemistry
  • Supramolecular chemistry
  • NMR spectroscopy
  • Micro arrays.

Opportunities to carry out postgraduate research towards an MPhil / PhD by research exist in all the areas identified above. Further information may be obtained from the NTU Graduate School.

External activity

Sponsors and collaborators

Current and recent research is being carried out with the collaboration, funding and / or support of:

Recent projects

  • NERC - Research Towards the Next Generation of Immunicological Therapeutic Vaccines and Delivery Systems for the Treatment of Uveal Melanoma
  • NTU and EPSRC - Supramolecular Therapeutic Transport Devices
  • Lachesis and HIRF - Magnetic Resonance Array System (M-RAY)
  • NTU - Templated Nanometre Scale Capsules.

Publications

Selected publications

For full list click 'Go to Gareth Cave's publications' link above.

See all of Gareth Cave's publications...

Press expertise

  • Food supplements / fortification
  • Drug delivery
  • Medical imaging
  • Biofuels
  • Hydrogen storage
  • Lab scale up
  • Nanoscience
  • Nanotechnology
  • Green technologies