Dr. Gareth McVicker is a lecturer and researcher in microbiology at Nottingham Trent University and is based at the Clifton Campus. Dr. McVicker teaches on various modules at all degree stages, in the topics of general microbiology, microbial genetics and molecular pathogenesis. His research focuses on the maintenance and transmission of mobile genetic elements encoding virulence and resistance traits in bacteria.
Dr. McVicker obtained his PhD from the University of Kent with Dr. Ian Blomfield working on regulation of virulence gene expression in E. coli. He went on to complete a postdoctoral position at the University of Sheffield with Simon Foster, working on the impact of antimicrobial resistance on systemic Staphylococcus aureus infection. After this, Dr. McVicker studied the mechanisms underlying differential virulence plasmid stability in Shigella with Christoph Tang at the Sir William Dunn School of Pathology, University of Oxford.
Dr. McVicker’s research focusses on the contribution of toxin-antitoxin modules and other stability systems to both the vertical and horizontal transfer of mobile genetic elements within bacterial populations, using pathogenic E. coli as a model. Of particular interest are enteropathogens with unusual, diverse or poorly-characterised plasmids, such as E. coli O157 and O104.
Member of the Microbiology Society (http://www.microbiologysociety.org/)
Deletion of toxin-antitoxin systems in the evolution of Shigella sonnei as a host-adapted pathogen. McVicker G and Tang CM, Nature Microbiology, 2016, 2, 16204
Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS. McDowell MA, Marcoux J, McVicker G, Johnson S, Fong YH, Stevens R, Bowman LAH, Degiacomi MT, Yan J, Wise A, Friede ME, Benesch JLP, Deane JE, Tand CM, Robinson CV and Lea SM, Molecular Microbiology, 2016, 99 (4), 749–766
Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention. McVicker G, Prajsnar TK, Williams A, Wagner NL, Boots M, Renshaw SA and Foster SJ, PLOS Pathogens, 2014, 10 (2)
RfaH suppresses small RNA MicA inhibition of fimB expression in Escherichiacoli K-12. Moores A, Chipper-Keating S, Sun L, McVicker G, Wales L, Gashi K and Blomfield IC, Journal of Bacteriology, 2014, 196 (1), 148–156
A privileged intraphagocyte niche is responsible for disseminated infection of Staphylococcus aureus in a zebrafish model. Prajsnar TK, Hamilton R, Garcia-Lara J, McVicker G, Williams A, Boots M, Foster SJ and Renshaw SA, Cellular Microbiology, 14 (10), 1600–1619
SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12. McVicker G, Sun L, Sohanpal BK, Gashi K, Williamson RA, Plumbridge J and Blomfield IC, Journal of Biological Chemistry, 2011, 286 (37), 32026–32035See all of Gareth McVicker's publications...