Role
Dr Winter is the subject leader for Microbiology teaching at NTU and together with Dr Lesley Hoyles, leads the Antimicrobial Resistance, Omics and Microbiota research group. Dr Winter is Course Leader for the BSc and MBiol Microbiology courses and Module Leader for the Host-Pathogen Interactions module. She supervises PhD, Masters and undergraduate research projects on Helicobacter pylori virulence, bacterial membrane vesicles and antimicrobial resistance.
Career overview
Dr Winter completed a PhD in parasite immunology and vaccine design at The University of Nottingham in 2004. She then worked as a postdoctoral researcher at The University of Nottingham until 2014 on projects including:
- cloning and expression of fluorescently labelled synuclein proteins for the development of in vitro and in vivo models of protein aggregation in Parkinson's disease,
- cloning, expression and characterisation (X-ray crystallography, protein-protein and protein-DNA interactions) of proteins involved in bacterial and archaeal DNA replication.
- H. pylori toxin and membrane vesicle roles in immune modulation and pathogenicity
Alongside her research, she has worked in a variety of teaching roles including demonstrating at The University of Nottingham 2001-2006, and Associate Lecturer at The Open University 2009-2019.
Dr Winter joined NTU as a Senior Lecturer in Microbiology in 2014 and became a Principal Lecturer in 2018.
Research areas
Dr Winter is interested in bacteria-host interactions with a particular focus on the causative agent of peptic ulcers and gastric cancer, Helicobacter pylori. She is a member of the Antimicrobial Resistance, Omics and Microbiota research group at NTU within the Centre for Health, Ageing and Understanding Disease.
Her main research interests include:
- Roles of bacterial membrane vesicles in pathogenesis, stress survival, antibiotic resistance and immune modulation.
- H. pylori pathogenicity
- Antimicrobial resistance, antimicrobial stewardship, infection prevention and control
Opportunities to carry out postgraduate research towards an MPhil / PhD exist in the areas identified above. Further information may be obtained from the NTU Graduate School.
External activity
Dr Winter is a member of The Microbiology Society and a peer reviewer for journals including:
She is a volunteer tutor at The People's Open Access Education Initiative, which provides low cost Public Health training online to students in low and middle income countries.
Publications
MURRAY, B.O., DAWSON, R.A., ALSHARAF, L.M. and ANNE WINTER, J., 2020. Protective effects of Helicobacter pylori membrane vesicles against stress and antimicrobial agents. Microbiology. ISSN 1465-2080
DAVIES, C., TAYLOR, A.J., ELMI, A., WINTER, J., LIAW, J., GRABOWSKA, A.D., GUNDOGDU, O., WREN, B.W., KELLY, D.J. and DORRELL, N., 2019. Sodium taurocholate stimulates Campylobacter jejuni outer membrane vesicle production via down-regulation of the maintenance of lipid asymmetry pathway.Frontiers in Cellular and Infection Microbiology, 9: 177. ISSN 2235-2988
PATOLI, B.B., WINTER, J.A., PATOLI, A.A., DELAHAY, R.M. and BUNTING, K.A., 2017. Co-expression and purification of the RadA recombinase with the RadB paralog from Haloferax volcanii yields heteromeric ring-like structures.Microbiology, 163, pp. 1802-1811. ISSN 1350-0872
HUSSAIN, K., LETLEY, D.P., GREENAWAY, A.B., KENEFECK, R., WINTER, J.A., TOMLINSON, W., RHEAD, J., STAPLES, E., KANEKO, K., ATHERTON, J.C. and ROBINSON, K., 2016. Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T Cells. Frontiers in Immunology, 7. ISSN 1664-3224
AMILON, K.R., LETLEY, D.P., WINTER, J.A., ROBINSON, K. and ATHERTON, J.C., 2015. Expression of the Helicobacter pylorivirulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5′ untranslated region of the transcript. Molecular Microbiology, 98 (5), pp. 831-846. ISSN 0950-382X
WINTER, J., LETLEY, D., RHEAD, J., ATHERTON, J. and ROBINSON, K., 2014. Helicobacter pylori membrane vesicles stimulate innate pro- and anti-inflammatory responses and induce apoptosis in Jurkat T Cells. Infection and Immunity, 82 (4), pp. 1372-1381. ISSN 0019-9567
WINTER, J.A., LETLEY, D.P., COOK, K.W., RHEAD, J.L., ZAITOUN, A.A.M., INGRAM, R.J.M., AMILON, K.R., CROXALL, N.J., KAYE, P.V., ROBINSON, K. and ATHERTON, J.C., 2014. A role for the vacuolating cytotoxin, VacA, in colonization and Helicobacter pylori–induced metaplasia in the stomach. Journal of Infectious Diseases, 210 (6), pp. 954-963. ISSN 0022-1899
Course(s) I teach on
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Undergraduate | Full-time / Sandwich | 2023COURSE
Microbiology - BSc (Hons)
https://www.ntu.ac.uk/course/science-and-technology/ug/bsc-hons-microbiology
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Undergraduate | Full-time / Sandwich | 2023
https://www.ntu.ac.uk/course/science-and-technology/ug/mbiol-microbiology
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Postgraduate taught | Full-time / Part-time / Sandwich | 2023COURSE
Molecular Microbiology - MSc
https://www.ntu.ac.uk/course/science-and-technology/pg/msc-molecular-microbiology