Karin Garrie

Karin Garrie

Principal Lecturer

School of Science & Technology

Staff Group(s)
Bioscience

Role

Dr Garrie is a Lecturer / Senior Lecturer in Immunology, part of the Biosciences Team in the School of Science and Technology. She is Module Leader for Immunology and Virology (undergraduate BSc (Hon), NVQ level 6, year 3), joint co-module leader for Introduction to Cell Biology (undergraduate BSc (Hon), NVQ level 4, year 1) and Clinical Immunology (postgraduate M level, flexible learning module, NVQ level 7, year 4, to start academic year 2015/2016). In addition she is the Biomedical Science Course Tutor for year 1 students. Dr Garrie is also involved as a lecturer on additional undergraduate modules.

Career overview

  • Senior/Lecturer in Biosciences, NTU (2012-2014)
  • NACC Research Fellow, University of Nottingham (2009-2011)
  • AICR Senior Research Fellow, University of Nottingham (2006-2009)
  • WT VIP Awardee, University of Nottingham (2006)
  • WT Senior Research Fellow, University of Leicester (2005)
  • Doctor rerum naturalium, University of Freiburg, Germany (2005)
  • WT Research Associate, University of Leicester (2000-2005)

Research areas

Dr Garrie’s research background is in the field of cell signalling, epigenetics, and cancer research with emphasis on leukemia and colorectal cancer. Current research interests include:

  • Etiological studies on HPV in oropharyngeal cancer patients
  • The role of receptor signalling on colorectal cancer
  • The role of novel factors driving islet inflammation and pancreatic beta-cell death in Type-2 diabetes.

Opportunities to carry out postgraduate research towards an MPhil/PhD in the School of Science and Technology exist and further information may be obtained from the NTU Graduate School.

External activity

Sponsors and collaborators

Aspects of Dr Garrie's current research are carried out in collaboration with Dr Allibone, NUH Nottingham and in separate work with Prof Ilyas, University of Nottingham. Dr Garrie also performs research with Dr Turner and Prof Ball at NTU.

Publications

Selected publications (under the name of Kindle)

  • DNA content analysis of colorectal cancer defines a distinct 'microsatellite and chromosome stable' group but does not predict response to radiotherapy. Fadhil W, Kindle K, Jackson D, Zaitoun A, Lane N, Robins A and Ilyas M, International Journal of Experimental Pathology, 2014, 95 (1), 16-23
  • Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells. Collins HM, Abdelghany MK, Messmer M, Yue B, Deeves SE, Kindle KB, Mantelingu K, Aslam A, Winkler GS, Kundu TK and Heery DM, BMC Cancer, 2013, 13 (37)
  • C-terminal tensin-like gene functions as an oncogene and promotes cell motility in pancreatic cancer. Al-Ghamdi S, Cachat J, Albasri A, Ahmed M, Jackson D, Zaitoun A, Guppy N, Otto WR, Alison MR, Kindle KB and Ilyas M, Pancreas, 2013, 42 (1), 135-140
  • Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas. Al-Ghamdi S, Albasri A, Cachat J, Ibrahem S, Muhammad BA, Jackson D, Nateri AS, Kindle KB and Ilyas M. PLoS One, 2011, 6 (6), e20919
  • Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer. Albasri A, Al-Ghamdi S, Fadhil W, Aleskandarany M, Liao YC, Jackson D, Lobo DN, Lo SH, Kumari R, Durrant L, Watson S, Kindle KB and Ilyas M, Oncogene, 2011, 30 (26), 2997-3002
  • Interleukin-4-inducing principle from Schistosoma mansoni eggs contains a functional C-terminal nuclear localization signal necessary for nuclear translocation in mammalian cells but not for its uptake. Kaur I, Schramm G, Everts B, Scholzen T, Kindle KB, Beetz C, Montiel-Duarte C, Blindow S, Jones AT, Haas H, Stolnik S, Heery DM and Falcone FH, Infection and Immunity, 2011, 79 (4), 1779-1788
  • MOZ-TIF2-mediated destruction of CBP/p300 is blocked by calpain inhibitor 2.Kindle KB, Collins HM and Heery DM, Leukemia 2010, 24 (7), 1359-1361
  • SUMOylation regulates the nuclear mobility of CREB binding protein and its association with nuclear bodies in live cells. Ryan CM, Kindle KB, Collins HM and Heery DM, Biochemical and Biophysical Research Communications, 2010, 391 (1), 1136-1141

See all of Karin Garrie's publications...