Professor Nadia Chuzhanova is a Professor of Biomedical Mathematics. She is involved in teaching Probability & Statistical Inference at undergraduate level and Research Methodology & Ethics, Computational Statistics & Data Analysis and Statistical Data Analysis modules at postgraduate level. She also supervises PhD students and the final year projects in Statistics/Mathematics and Bioinformatics.
- Reader in Bioinformatics and a Head of Bioinformatics, Biophysics and Self-Organising Systems cluster at The University of Central Lancashire, Preston (2006-2010)
- Research Fellow, Lecturer, Head of Bioinformatics at Cardiff University (1998-2006)
Professor Chuzhanova is a member of the Biomathematics and Bioinformatics research group.
Research group blog.
- Mr Daniel Buxton (DoS)
- Miss Bethany Hall (DoS)
- Miss Rebecca Martin (co-supervisor)
- Mr Bachir Djamal Touami (co-supervisor)
Areas of research interest include Bioinformatics of mutagenesis with the aim of developing novel mathematical, statistical and computational methods and algorithms for identification of specific DNA sequence features, epigenetic factors and other architectural features that mediate and drive mutagenesis both in pathology and evolution.
Professor Chuzhanova is particularly interested in developing approaches for predicting remotely acting regulatory elements and in understanding their role in disease developments and progression.
Opportunities to carry out postgraduate research towards an MPhil/PhD exist in all the areas identified above. Further information may be obtained from the NTU Graduate School.
Professor Chuzhanova is a member of the ESRC DTC/DTP Peer Review College.
Sponsors and collaborators
Current and recent research is being conducted with the collaboration, funding and/or support of:
University collaborations include:
- Professor David Cooper (Institute of Medical Genetics, Cardiff University, UK)
- Professor Jian-Min Chen (INSERM U1078 and EFS – Bretagne, France)
- Dr Valentina Escott-Price (MRC Centre for Neuro-Psychiatric Genetics and Genomics, Cardiff University, UK)
- Dr Albino Bacolla (Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA)
- A role for non-B DNA forming sequences in mediating micro-lesions causing human inherited disease. Kamat MA, Bacolla A, Cooper DN, Chuzhanova N, Human Mutation, 2016, 37 (1), 65-73
- Remotely-acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD. Mayes MB, Morgan T, Winston J, Buxton DS, Kamat MA, Smith D, Williams M, Martin RL, Dirk A Kleinjan DA, Cooper DN, Upadhyaya M, Chuzhanova N, Human Genomics, 2015, 9, 25
- Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitutions in human cells. Bacolla A, Wang G, Jain A, Chuzhanova NA, Cooper DN, Bohr VA, Vasquez KM, J Biol Chem, 2011, 286, 10017-10026
- Genes, mutations and human inherited disease at the dawn of the 100K mutome era. Cooper DN, Chen JM, Ball EV, Howells K, Mort M, Phillips AD, Chuzhanova NA, Krawczak M, Kehrer-Sawatzki H, Stenson PD, Human Mutat, 2010, 31, 631-655
- SPRED1 mutations (Legius Syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. Chuzhanova NA, Spurlock G, Bennett E, Thomas N, H-Ping Jim, Side L, Davies S, Haan E, Kerr B, Huson SM, Upadhyaya M, Journal of Medical Genetics, 2009, 46 (7), 431-438
- Gene conversion causing human inherited disease: evidence for involvement of non B DNA forming sequences and recombination promoting motifs in DNA breakage and repair. Chuzhanova NA, Chen JM, Bacolla A, Patrinos GA, Ferec C, Wells RD, Cooper DN, Human Mutation, 2009, 30 (8), 1189-1198
- High resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybrization. Mantripragoda KK, Spurlock G, Kluwe L, Chuzhanova NA, Ferner RE, Frayling IM, Dumanski JP, Guha A, Maurner V, Upadhyaya M, Clinical Cancer Research, 2008, 14, 1015-1024
- A meta-analysis of nonsense mutations causing human genetic disease. Mort M, Ivanov D, Cooper DN, Chuzhanova NA. Human Mutat, 2008, 29, 1037-1047