Sergio_Rutella

Sergio Rutella

Professor

School of Science & Technology

Role

Professor Rutella is the Professor of Cancer Immunotherapy at the John van Geest Cancer Research Centre. He is a licensed haematologist with a long-standing clinical and research interest in immunotherapy approaches for patients with leukaemia. At NTU, Professor Rutella’s research will focus on visualising the state of cancer-immune interactions in individual patients and on biomarker discovery, with the aim to guide treatment choices and improve clinical outcome.

Career overview

2014-2016: Executive Director of Clinical Research, Sidra Medical and Research Center, Doha, Qatar

2012-2014: Chairman, Immunohaematology and Transfusion Medicine, Bambino Gesù Children’s Hospital, Rome, Italy

2000-2012: Assistant Professor of Haematology and Consultant Haematologist, Agostino Gemelli University Polyclinic, Catholic University Medical School, Rome, Italy

Research areas

Areas of research interest include:

Discovery of predictive outcome biomarkers in cancer patients. Current work is focusing on the identification of specific gene signatures that reflect immune system activation, and help predict treatment response as well as risk of relapse in patients with cancer. Our NanoString FLEX instrument (one of only 6 in the UK) utilises a clinic-ready high-throughput platform with digital detection and direct molecular barcoding of individual target molecules. Specific proteins of interest are validated and quantified using Clinical Proteomics. All data analytic and interpretation activities are supported by advanced Bioinformatics and Computational Intelligence expertise.

Novel immunotherapy approaches for haematological malignancies. This research work tackles the immune suppressive circuits that prevent the establishment of effective anti-tumour responses in patients with acute leukaemia. The ultimate goal of these studies is to identify molecular pathways within the immunological tumour microenvironment that can be targeted in order to improve patient outcome. For instance, small molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1), an immune suppressive tryptophan-catabolising enzyme which is expressed in a subset of patients with acute myeloid leukaemia, are currently being used in patients with advanced-stage cancers.

Opportunities to carry out postgraduate research towards an MPhil/PhD exist within the School of Science and Technology and further information may be obtained from the NTU Doctoral School.

External activity

Fellow, Royal College of Pathologists, London, UK (2017)

Medical Licensing:

    • Full with Specialist Registration with a Licence to Practice (Haematology); ‘Ordine dei Medici Chirurghi e degli Odontoiatri’, Italy (reference number: 44979); from 10/06/1993
    • Full with Specialist Registration with a Licence to Practice (Haematology); General Medical Council, United Kingdom (reference number: 7555758); from 06/01/2017

Professional memberships:

Grant Reviewer:

Sponsors and collaborators

Current research is being conducted with the collaboration of:

Research funding includes:

  • Microenvironmental targets for restoring anti-tumour immunity in childhood acute leukaemia, Qatar National Research Fund (2016-2019), £598,000
  • Alterations of A-to-I RNA editing in acute myeloid leukaemia, Italian Ministry of University and Scientific Research (2012-2014), £70,110
  • Human mesenchymal stromal cells: Optimization of GMP-grade in vitro protocols as a pre-requisite for clinical application, Regione Lazio, Dipartimento Economico e Occupazionale (Lazio Region , Department of Economic and Occupational) (2013-2014), £346,500
  • Molecular determinants of immune dysfunction in childhood leukaemia, Bambino Gesú Children’s Hospital (2012-2013), £84,520
  • Indoleamine 2,3-dioxygenase 1 (IDO1) and immune suppression in human malignancies, Italian Ministry of University and Scientific Research (2011-2013), £39,730
  • Hepatocyte growth factor and immune dysfunction in multiple myeloma, Italian Association for Cancer Research (2009-2012), £126,800

Publications

Systematic evaluation of immune regulation and modulation. Stroncek DF, Butterfield LH, Cannarile MA, Dhodapkar MV, Greten TF, Grivel JC, Kaufman DR, Kong HH, Korangy F, Lee PP, Marincola F, Rutella S, Siebert JC, Trinchieri G, Seliger B.  Journal for Immunotherapy of Cancer 2017; 5: 21.

Mesenchymal stem cells reduce colitis in mice via release of TSG6, independently of their localization to the intestine. Sala E, Genua M, Petti L, Anselmo A, Arena V, Cibella J, Zanotti L, D’Alessio S, Scaldaferri F, Luca G, Arato I, Calafiore R, Sgambato A, Rutella S, Locati M, Danese S and Vetrano S, Gastroenterology, 2015, 149 (1), 163-76

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation. Genua M, D’Alessio S, Cibella J, Gandelli A, Sala E, Correale C, Arena V, Malesci A, Rutella S, Ploplis VA, Vetrano S, and Danese S, Gut,  2015, 64 (4), 589-600

Indoleamine 2,3-dioxygenase 1 (IDO1) activity in leukemia blasts correlates with poor outcome in childhood acute myeloid leukemia. Folgiero V, Goffredo BM, Filippini P, Masetti R, Bonanno G, Caruso R, Bertaina V, Mastronuzzi A, Gaspari S, Zecca M, Torelli GF, Testi AM, Pession A, Locatelli F, and Rutella S, Oncotarget, 2014, 5 (8), 2052-64

Kindlin-3-independent adhesion of neutrophils from leukocyte adhesion deficiency type III. van de Vijver E, Tool ATJ, Sanal O, Cetin M, Unal S, Aytac S, Seeger K, Pagliara D, Rutella S, van den Berg TK and Kuijpers TW, Journal of Allergy and Clinical Immunology, 2014, 133 (4), 1215-18

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with non-malignant disorders. Bertaina A, Merli P, Rutella S, Pagliara D, Bernardo ME, Masetti R, Pende D, Falco ME, Handgretinger R, Moretta F, Lucarelli B, Brescia LP, Li Pira G, Testi M, Cancrini C, Kabbara N, Carsetti R, Finocchi A, Moretta A, Moretta L, Locatelli F, Blood, 2014, 124 (5), 822-6

Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response. Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A, Arena V, Peyrin-Biroulet L, Caprioli F, Passini N, Panina-Bordignon P, Repici A, Malesci A, Rutella S, Rescigno M, and Danese S, Gastroenterology, 2013, 144 (2), 346-56

Results of the AIEOP AML 2002/01 multicenter, prospective trial for treatment of children with acute myeloid leukemia. Pession A, Masetti R, Rizzari C, Putti MC, Casale F, Fagioli F, Luciani M, Lo Nigro L, Menna G, Micalizzi C, Santoro N, Testi AM, Zecca M, Biondi A, Pigazzi M, Rutella S, Rondelli R, Basso G, and Locatelli F, Blood, 2013, 122 (2) 170-8

How I treat relapsed childhood acute lymphoblastic leukemia. Locatelli F, Schrappe M, Bernardo ME, and Rutella S, Blood, 2012, 120 (14), 2807-16

See all of Sergio Rutella's publications...

Press expertise

  • Haematological cancers
  • Leukaemia
  • Immunotherapy (harnessing the immune system to fight cancer)
  • Personalised cancer medicine
  • Cancer genomics