Gene Expression Regulation Group

Dr Montiel-Duarte has a background in liver and leukaemia-related conditions and her current research aims to elucidate novel mechanisms for gene regulation. Her group is currently focused on the following research areas.

Current Research Areas:

• Transcription start process and its connection to translation efficiency.
• Development of new techniques to study RNA modifications.
• RNA cargo of extracellular vesicles and alterations due to drug resistance.

Dr Montiel-Duarte is an Editorial Board Member for Scientific Reports and a Guest Editor for Biology. And has reviewed papers for Antioxidants, Cells, Cancers, The International Journal of Molecular Science, DNA and Cell Biology, Bioscience Reports and Scientific Reports. She is a Grant Committee Member for the Biochemical Society and has reviewed research grants for CONACYT, the Mexican National Council of Science and Technology.

Dr Montiel-Duarte collaborates with the following:

• Dr Maria Iraburu, Vice President of Faculty Affairs (University of Navarra, Spain)
• Dr Keith Spriggs, Associate Professor in gene regulation (University of Nottingham)
• Dr Marta Varela-Rey (CIC bioGUNE, Spain)

Role of AGAP2 in the profibrogenic effects induced by TGFβ in LX-2 hepatic stellate cells.

NAVARRO-CORCUERA A., LÓPEZ-ZABALZA M.J., MARTÍNEZ-IRUJO J.J., ÁLVAREZ-SOLA G., ÁVILA M.A., IRABURU M.J., ANSORENA E., MONTIEL-DUARTE C., (2019).. BBA Molecular Cell Research, 1866(4), pp. 673-685.

SP1 and RARα regulate AGAP2 expression in cancer.

DOUSH Y., SURANI A.A., NAVARRO-CORCUERA A., MCARDLE S., BILLETT E.E., MONTIEL-DUARTE C., (2019). Scientific Reports, 9(1), pp. 390.

We have access within the John van Geest Cancer Research Centre to instrumentation to facilitate multi-omic analyses including gene expression micro-array, Nanostring platform, mass spectrometers and laser capture microdissection.