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Alasdair Hubbard

Lecturer

School of Science & Technology

Role

Alasdair is a Lecturer in Microbiology at NTU

Career overview

Alasdair graduated with a BSc (Hons) in Microbiology from University of Leeds in 2007. After completion of his undergraduate degree, he worked at the Health Protection Agency, identifying bacterial and viral contamination of food and water, and Dstl, Porton Down. Alasdair went on to complete a Ph.D at St George's, University of London in 2015 in Medical Microbiology and Biophysics.

Post Ph.D, he worked as a Postdoctoral Scientist at a molecular diagnostic company to rapidly identify bacterial infections direct from clinical samples. Alasdair then took up a Research Assistant position at the University of Oxford working on characterising the environmental resistome. Between 2017 and 2021, he was a Postdoctoral Research Associate at the Liverpool School of Tropical Medicine working on a variety of projects, including:

- Identification of antimicrobial proteins from snake venom

- Characterising epistatic interactions between antimicrobial resistant mutations

- Determining novel resistance mechanisms

Since July 2021, Alasdair has been a Lecturer in Microbiology at NTU.

Research areas

Alasdair is interested in improving the translation of evolutionary studies of antimicrobial resistant to clinical practice using models which mimic the human body. He is also interested in trying to understand the mismatch between phentypic resistance and the genetic determiants of resistance to improve tools to predict antimcirobial resistance.

Alasdair is part of the Antimicrobial Resistance, Omics and Microbiota research group at NTU within the Centre for Health, Ageing and Understanding Disease.

External activity

Alasdair is a member of the Microbiology Society and Society for Applied Microbiology, as well as a mentor for the Social Mobility Foundation.

Publications

Moyo, S. J., Manyahi, J., Hubbard, A. T. M., Byrne, R. L., Masoud, N. S., Aboud, S., Manji, K., Blomberg, B., Langeland, N. & Roberts, A. P. (2021a). Molecular characterisation of the first New Delhi metallo-β-lactamase 1-producing Acinetobacter baumannii from Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene 115(9):1080-1085. 10.1093/trstmh/traa173.

Shaw, L. P., Chau, K. K., Kavanagh, J., Abuoun, M., Stubberfield, E., Gweon, H. S., Barker, L., Rodger, G., Bowes, M. J., Hubbard, A. T. M., Pickford, H., Swann, J., Gilson, D., Smith, R. P., Hoosdally, S. J., Sebra, R., Brett, H., Peto, T. E. A., Bailey, M. J., Crook, D. W., Read, D. S., Anjum, M. F., Walker, A. S., Stoesser, N. & Consortium, R. (2021). Niche and local geography shape the pangenome of wastewater-and livestock-associated Enterobacteriaceae. Science Advances 10.1126/sciadv.abe3868.

Hubbard, A. T. M., Bulgasim, I. & Roberts, A. P. (2021). A novel hemA mutation is responsible for a small-colony-variant phenotype in Escherichia coli. Microbiology (Society for General Microbiology) 167(3). 10.1099/mic.0.000962.

Nikolaou, E., Hubbard, A. T. M., Botelho, J., Marschall, T. A. M., Ferreira, D. M. & Roberts, A. P. (2020). Antibiotic Resistance Is Associated with Integrative and Conjugative Elements and Genomic Islands in Naturally Circulating Streptococcus pneumoniae Isolates from Adults in Liverpool, UK. Genes 11(6). 10.3390/genes11060625.

Hubbard, A. T. M., Newire, E., Botelho, J., Reiné, J., Wright, E., Murphy, E. A., Hutton, W. & Roberts, A. P. (2020a). Isolation of an antimicrobial‐resistant, biofilm‐forming, Klebsiella grimontii isolate from a reusable water bottle. MicrobiologyOpen 9(6). 10.1002/mbo3.1023.

Hubbard, A. T. M., Mason, J., Roberts, P., Parry, C. M., Corless, C., van Aartsen, J., Howard, A., Bulgasim, I., Fraser, A. J., Adams, E. R., Roberts, A. P. & Edwards, T. (2020b). Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of blaTEM-1B. Nature communications 11(1). 10.1038/s41467-020-18668-2.

Hong, W. D., Benayoud, F., Nixon, G. L., Ford, L., Johnston, K. L., Clare, R. H., Cassidy, A., Cook, D. A. N., Siu, A., Shiotani, M., Webborn, P. J. H., Kavanagh, S., Aljayyoussi, G., Murphy, E., Steven, A., Archer, J., Struever, D., Frohberger, S. J., Ehrens, A., Hübner, M. P., Hoerauf, A., Roberts, A. P., Hubbard, A. T. M., Tate, E. W., Serwa, R. A., Leung, S. C., Qie, L., Berry, N. G., Gusovsky, F., Hemingway, J., Turner, J. D., Taylor, M. J., Ward, S. A. & O’neill, P. M. (2019). AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. Proceedings of the National Academy of Sciences 116(4). 10.1073/pnas.1816585116.

De Maio, N., Shaw, L. P., Hubbard, A. T. M., George, S., Sanderson, N. D., Swann, J., Wick, R., Abuoun, M., Stubberfield, E., Hoosdally, S. J., Crook, D. W., Peto, T. E. A., Sheppard, A. E., Bailey, M. J., Read, D. S., Anjum, M. F., Walker, A. S. & Stoesser, N. (2019). Comparison of long-read sequencing technologies in the hybrid assembly of complex bacterial genomes. Microbial Genomics 5(9). 10.1099/mgen.0.000294.

Rooney, C. M., Sheppard, A. E., Clark, E., Davies, K., Hubbard, A. T. M., Sebra, R., Crook, D. W., Walker, A. S., Wilcox, M. H. & Chilton, C. H. (2019). Dissemination of multiple carbapenem resistance genes in an in vitro gut model simulating the human colon. Journal of antimicrobial chemotherapy 74(7):1876-1883. 10.1093/jac/dkz106.

Hubbard, A. T. M., Jafari, N. V., Feasey, N., Rohn, J. L. & Roberts, A. P. (2019). Effect of Environment on the Evolutionary Trajectories and Growth Characteristics of Antibiotic-Resistant Escherichia coli Mutants. Frontiers in Microbiology 10. 10.3389/fmicb.2019.02001.

Gweon, H. S., Shaw, L. P., Swann, J., De Maio, N., Abuoun, M., Niehus, R., Hubbard, A. T. M., Bowes, M. J., Bailey, M. J., Peto, T. E. A., Hoosdally, S. J., Walker, A. S., Sebra, R. P., Crook, D. W., Anjum, M. F., Read, D. S. & Stoesser, N. (2019). The impact of sequencing depth on the inferred taxonomic composition and AMR gene content of metagenomic samples. Environmental Microbiome 14(1). 10.1186/s40793-019-0347-1.

Reynolds, M. E., Phan, H. T. T., George, S., Hubbard, A. T. M., Stoesser, N., Maciuca, I. E., Crook, D. W. & Timofte, D. (2019). Occurrence and characterization of Escherichia coli ST410 co-harbouring blaNDM-5, blaCMY-42 and blaTEM-190 in a dog from the UK. Journal of Antimicrobial Chemotherapy 74(5). 10.1093/jac/dkz017.

Rehal, R., Gaffney, P. R. J., Hubbard, A. T. M., Barker, R. D. & Harvey, R. D. (2019). The pH-dependence of lipid-mediated antimicrobial peptide resistance in a model staphylococcal plasma membrane: A two-for-one mechanism of epithelial defence circumvention. European journal of pharmaceutical sciences 128:43-53. 10.1016/j.ejps.2018.11.017.

Hubbard, A. T. M., Davies, S. E. W., Baxter, L., Thompson, S., Collery, M. M., Hand, D. C., Thomas, D. J. I. & Fink, C. G. (2018). Comparison of the first whole genome sequence of ‘Haemophilus quentini’ with two new strains of ‘Haemophilus quentini’ and other species of Haemophilus. Genome 61(5):379-385. 10.1139/gen-2017-0195.

Hubbard, A. T. M., Coates, A. R. & Harvey, R. D. (2017). Comparing the action of HT61 and chlorhexidine on natural and model Staphylococcus aureus membranes. Journal of antibiotics 70(10):1020-1025 10.1038/ja.2017.90.

Phillips, D. J., Harrison, J., Richards, S., Mitchell, D. E., Tichauer, E., Hubbard, A. T. M., Guy, C., Hands-Portman, I., Fullam, E. & Gibson, M. I. (2017). Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules. Biomacromolecules 18(5):1592-1599 10.1021/acs.biomac.7b00210.

Phan, H. T. T., Stoesser, N., Maciuca, I. E., Toma, F., Szekely, E., Flonta, M., Hubbard, A. T. M., Pankhurst, L., Do, T., Peto, T. E. A., Walker, A. S., Crook, D. W. & Timofte, D. (2017). Illumina short-read and MinION long-read WGS to characterize the molecular epidemiology of an NDM-1 Serratia marcescens outbreak in Romania. Journal of Antimicrobial Chemotherapy 73(3). 10.1093/jac/dkx456.

Rehal, R. P., Marbach, H., Hubbard, A. T. M., Sacranie, A. A., Sebastiani, F., Fragneto, G. & Harvey, R. D. (2017). The influence of mild acidity on lysyl-phosphatidylglycerol biosynthesis and lipid membrane physico-chemical properties in methicillin-resistant Staphylococcus aureus. Chemistry and physics of lipids 206:60-70. 10.1016/j.chemphyslip.2017.06.007.

Hubbard, A. T. M., Barker, R., Rehal, R., Vandera, K. A. A., Harvey, R. D. & Coates, A. R. M. (2017). Mechanism of Action of a Membrane-Active Quinoline-Based Antimicrobial on Natural and Model Bacterial Membranes. Biochemistry 56(8). 10.1021/acs.biochem.6b01135.

George, S., Pankhurst, L., Hubbard, A. T. M., Votintseva, A., Stoesser, N., Sheppard, A. E., Mathers, A., Norris, R., Navickaite, I., Eaton, C., Iqbal, Z., Crook, D. W. & Phan, H. T. T. (2017). Resolving plasmid structures in Enterobacteriaceae using the MinION nanopore sequencer: assessment of MinION and MinION/Illumina hybrid data assembly approaches. Microbial genomics 3(8):e000118. 10.1099/mgen.0.000118.

Hubbard, A. T. M., Davies, S. E. W., Baxter, L., Thompson, S., Collery, M. M., Hand, D. C., Fink, C. G. & Thomas, D. J. I. (2016). Draft Whole-Genome Sequence of a Haemophilus quentini Strain Isolated from an Infant in the United Kingdom. Genome announcements (Washington, DC) 4(5) 10.1128/genomeA.01075-16.

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