Carole Perry

Carole Perry

Distinguished Professor

School of Science & Technology

Staff Group(s)
Chemistry and Forensic Science

Role

Professor Perry is responsible for oversight of research within the Chemistry and Forensic Science team; she supervises undergraduate projects in chemistry and forensics and postgraduate (masters level and PhD) in chemistry and in bioscience at the interface with chemistry; she teaches on the modules, Introduction to Inorganic Chemistry (level 1) and Chemistry beyond the Molecule (Level 4).

Professor Perry is a recipient of a Wolfson Research Merit Award (2013-2017).

Professor Perry is a professorial representative on the University Heads Information, Consultation and Negotiation Forum.

Professor Perry has been at NTU since 1993 and was Head of Chemistry from 2003-2008.

Career overview

Academic Positions:

  • Brunel University, Lecturer (1987-1993)
  • Oxford University, St Hilda’s College (1985-1987) E.P.A. Brereton Sherman Junior Research Fellowship

Externally funded competitive fellowships:

  • Israeli Ministry of Science and Technology (1992- 6 months at Weizmann Institute, Israel)
  • Royal Society (1991-1992- 6 weeks at Weizmann Institute, Israel)
  • CIBA Foundation (1986- 1 month at Scripps Institute, San Diego, USA).

Research areas

Professor Perry is Head of the Biomolecular Materials Interface Research Group.

Research Fellows:

  • David Belton
  • Graham Hickman
  • Marion Limo
  • Anna Sola-Rabada

Research Assistant:

Vacancy to be filled shortly

Research Students:

  • Mithun Parambath
  • Anna Sola-Rabada
  • Matthew Nicklin
  • Zayd Westcott
  • Veeru Thota
  • Robyn Plowright
  • One unfilled position

Visitors (academic year 2015-2016):

  • Padma Sahare, PhD student (Mexico) six weeks
  • Dr Olga Verokskina, PDRA (Irkutsk, Russia) three months
  • Masashi Ito, MSc student (Tokyo, Japan) three months
  • Monika Michaels, PhD student (Bremen, Germany) two months
  • Maria Desastre MSc student (Naumur, Belgium) three months

Research is focussed towards understanding what happens at the interface between biomolecules and materials. Current projects include:

  • The study of abiotic biotic interactions at the molecular level between materials such as platinum, zinc oxide and silica and peptides that have been identified by Phage display methods (AFOSR). The studies include identification of peptides that bind to specific minerals (phage display), identification of the structural features in the peptides required for binding (molecular modelling), binding studies of peptides and minerals (solution and solid state studies), thermodynamic studies of binding interactions (QCM-D and ITC), and, investigations of the materials that form (materials characterisation). The end goal is to produce a set of rules that can be used predictively with other materials systems.
  • The design and fabrication of chimeric fusion proteins based on cocoon and spider silk and the study of their interaction to understand design criteria for the generation of novel materials for a wide range of potential applications from health to military via performance sports (NIH and EPSRC).
  • Development of novel nanoparticle antibiotic conjugates with high antimicrobial activity (World Gold Council).
  • Fundamental studies of surfaces, including aspects of superhydrophobicity and flow (EPSRC). An extension of this is studies of how proteins behave on surfaces as the first stage in biomaterial recognition. Studies involve the generation of surfaces as well as detailed time dependent studies of protein conformation and binding on the chosen surfaces (Smith and Nephew).
  • Use of our knowledge of surfaces and protein interactions to generate novel mineralised surfaces for functional transistors, biomaterials and cancer studies.
  • Developing new tissue culture surfaces for use in biomaterials development and cancer studies.
  • Conversion of eggshells to useful products (TSB/ Innovate).
  • Identification of the role that bioavailable silicon species play in health.

Opportunities to carry out postgraduate research towards an MPhil /PhD exist in all the areas identified above. Further information may be obtained from the NTU Graduate School.

External activity

  • Fellow of the Royal Society of Chemistry (FRSC)
  • Fellow of Royal Microscopical Society (FRMS)
  • Chartered Chemist (CChem)
  • Member of the EPSRC College of Referees (2003-)
  • Panel member of DFG Research Council (Germany) (2005, 2006, 2011, 2013)
  • Elected Council member and trustee of the Royal Society of Chemistry (2007-2012)
  • Chair of the RSC audit committee (2009-2011)
  • RSC Member of Disciplinary Committee (2011-14)
  • RSC Member of Research Fund Committee (2013-)
  • Member of steering commitee UK Heads of Chemistry (2005-2012)
  • Chair of the UK Heads of Chemistry (2009-2011)
  • Visiting Professor Université Pierre et Marie Curie (Paris VI) (2002)
  • Gast Professor KIT, Karlsruhe (2012)
  • Research Professor in the Institute of Lasers, Photonics and BioPhotonics at the University of Buffalo, New York (2010-13)
  • Key involvement in the successful application to HEFCE for 'Chemistry the Next Generation' (2005) and 'Chemistry for our Future' (2006).
  • Editorial Board Member: Nature Scientific Reports (2012-); Silicon (2010-); Recent Patents in Nanotechnology (2006-)
  • Company director- SiActive (2009-)

Sponsors and collaborators

Current and recent research is being conducted with the collaboration, funding and / or support of:

Current university collaborations include Southampton University, Limnological Institute, Irkutsk, Mainz University, Scripps Institute, USA, Tufts University, USA, MIT, USA, Harvard University, USA, Akron University, USA, Deakin University, Australia.

Research funding in the period since 2007 includes:

  • EPSRC: EP/N026071/1 Exploring the MOF-peptide interface: from phage display to materials synthesis, thin films and composites £252,000  with D. Bradshaw, Southampton, (£370,000) Hendrik Heinz, Boulder and Andreas Tefort, Frankfurt (2016)
  • AFOSR: FA9550-16-1-0213) Probing Mechanisms of Biological-Materials Interactions; towards realizing biomimetic materials by understanding molecular-level interactions ($510,000) (2016)
  • British Council/ Mexican Government “Generating high value products form Mexican Horsetail for Biotech Applications” (2015-2016) £50,000
  • Innovate UK “Recovery and Processing of High Value Food and Pharmaceutical Ingredients from Waste Egg Shells” (2016-2017) 800k project £147,000 to NTU
  • AFOSR funds for purchase of Raman spectrometer (2014) $116,400.
  • Extracting high value products from egg shells TSB- Food for life (2014-2015) £55,000
  • NIH ca. Development of silk-silica nanocomposites for dental and bone repair (with Tufts University) 2013-2017 $440,000
  • AFOSR Computational and experimental studies of the abiotic-biotic interface (2013-2015) 510,000$
  • Deriving value from egg shell waste (TSB) 2012-2013 £25000
  • Sharp Industries “synthesis of vanadia coated silica nanoparticles” (2012) £10,000
  • AbVista “stabilisation of novel silicon supplement” coI, (2011) £13,500
  • Biotage “study of SLE materials and wettability” (2011-2013) £120,000
  • World Gold Council “Technological developments involving antibiotics and gold” (2011-2012) £65,000
  • Towards an understanding of Peptide-mineral interaction: a predictive approach, C C Perry, AFOSR (US Airforce) (2009 to 2012), £283,333
  • Biomineralisation, C C Perry, Marie Curie Training Network (2008 to 2012), £227,929
  • Silica-protein nanocomposites for dental repair, D L Kaplan, C C Perry, B Rutherford, NIH (2007 to 2012), $445,230
  • A novel approach to nanoscale materials assembly using bioengineered spider silk fusion proteins: a generic approach, C C Perry, EPSRC EP/E048439/1 (2007 to 2010), £268,248
  • Studies of Osseointegration, C C Perry, Smith and Nephew (2005 to 2010), £34,156
  • Synthetic models for biosilicification, C C Perry, V A Annenkov, Limnological Institute, Irkutsk and others from the University of Helsinki and Institute of Physics and Combustion EU/INTAS (2007 to 2009), £5,953
  • Studies of biosilicification and peptide mineral interactions, C C Perry, AFOSR (2006 to 2009), £250,000
  • Biomineralisation for lithography and microelectronics (Biolitho), C C Perry, EU 6th Framework (2006 to 2009), £133,273
  • Drag reduction and slip at solid-liquid interfaces, G McHale, C C Perry, M I Newton, EPSRC EP/D500826/1 (2005 to 2009) £205,498
  • Enhancing Water Sports Performance, G McHale, C C Perry and M I Newton EPSRC EP/E043097/1 (2007 to 2008), £110,369
  • New biomimetic synthetic polymers and organic-inorganic nanocomposites, C C Perry, Royal Society Joint Project Award (2006 to 2008), £12,000
  • Mechanism of antiperspirant action of aluminium salts, C C Perry, Unilever (2004 to 2008), £65,930
  • Studies of aluminium species in polymeric systems, C C Perry, Unilever (2006 to 2007), £48,000
  • Studies on antiperspirant actives, C C Perry, Unilever (2002 to 2007), £300,500
  • Oxide core shell particles, C C Perry, Qinetiq (2007), £20,000

Publications

Limo, M.J., Sola-Rabada, A., Boix, E., Thota, V., Westcott, Z.C., Puddu, V. and Perry, C.C., 2018. Interactions between metal oxides and biomolecules: From fundamental understanding to applications. Chemical Reviews. Issn 0009-2665 (Forthcoming)

Martín-Moldes, Z., Ebrahimi, D., Plowright, R., Dinjaski, N., Perry, C.C., Buehler, M.J. and Kaplan, D.L., 2018. Intracellular pathways involved in bone regeneration triggered by recombinant silk-silica chimeras. Advanced Functional Materials, 28 (27): 1702570. Issn 1616-301x

Rabada, A.S., Michaelis, M., Oliver, D.J., Roe, M., Colombi Ciacchi, L., Heinz, H. and Perry, C.C., 2018. Interactions at the silica-peptide interface: Influence of the extent of functionalization on the conformational ensemble. Langmuir. Issn 0743-7463

Belton, D.J., Plowright, R., Kaplan, D.L. and Perry, C.C., 2018. A robust spectroscopic method for the determination of protein conformational composition - application to the annealing of silk. Acta Biomaterialia, 73, Pp. 355-364. Issn 1742-7061

Volkov, V.V., Belton, D.J. and Perry, C.C., 2018. Do material discontinuities in silica affect vibration modes? The Journal of Physical Chemistry A. Issn 1089-5639

Annenkov, V.V., Danilovtseva, E.N., Pal'shin, V.A., Verkhozina, O.N., Shishlyannikova, T.A., Hickman, G.J. and Perry, C.C., 2018. Fluorescently-tagged polyamines for the staining of siliceous materials. Plant Physiology and Biochemistry, 125, Pp. 205-211. Issn 0981-9428

Sola-Rabada, A., Sahare, P., Hickman, G.J., Vasquez, M., Del Rio, J.A., Canham, L.T., Perry, C.C. and Agarwal, V., 2018. Biogenic porous silica and silicon sourced from Mexican giant horsetail (equisetum myriochaetum) and their application as supports for enzyme immobilization. Colloids and Surfaces B: Biointerfaces. Issn 0927-7765

Plowright, R., Belton, D.J., Kaplan, D.L. and Perry, C.C., 2017. Quantifying the efficiency of hydroxyapatite mineralising peptides. Scientific Reports, 7, P. 7681. Issn 2045-2322

Dinjaski, N., Plowright, R., Zhou, S., Belton, D.J., Perry, C.C. and Kaplan, D.L., 2017. Osteoinductive recombinant silk fusion proteins for bone regeneration. Acta Biomaterialia, 49, Pp. 127-139. Issn 1742-7061

Thota, V. and Perry, C.C., 2016. A review on recent patents and applications of inorganic material binding peptides. Recent Patents on Nanotechnology, 9. Issn 1872-2105

Volkov, V. and Perry, C.C., 2016. Modeling of infrared–visible sum frequency generation microscopy images of a giant liposome. Microscopy and Microanalysis. Issn 1431-9276

Sultan, A., Westcott, Z., Hughes, Z.E., Palafox-Hernandez, J.P., Giesa, T., Puddu, V., Buehler, M.J., Perry, C.C. and Walsh, T.R., 2016. Aqueous peptide-tio2 interfaces: Iso-energetic binding via either entropically- or enthalpically-driven mechanisms. Acs Applied Materials & Interfaces, 8, Pp. 18620-18630. Issn 1944-8244

See all of Carole Perry's publications...

Press expertise

  • Nanoparticles
  • Interfacial interactions
  • Silica
  • Biomineralization
  • Biomimetics
  • Extending the life of antibiotics
  • Electron microscopy