Carole Perry

Carole Perry

Distinguished Professor

School of Science & Technology

Staff Group(s)
Chemistry and Forensic Science

Role

Professor Perry is responsible for oversight of research within the Chemistry and Forensic Science team; she supervises undergraduate projects in chemistry and forensics and postgraduate (masters level and PhD) in chemistry and in bioscience at the interface with chemistry; she teaches on the modules, Introduction to Inorganic Chemistry (level 1) and Chemistry beyond the Molecule (Level 4).

Professor Perry is a recipient of a Wolfson Research Merit Award (2013-2017).

Professor Perry is a professorial representative on the University Heads Information, Consultation and Negotiation Forum.

Professor Perry has been at NTU since 1993 and was Head of Chemistry from 2003-2008.

Career overview

Academic Positions:

  • Brunel University, Lecturer (1987-1993)
  • Oxford University, St Hilda’s College (1985-1987) E.P.A. Brereton Sherman Junior Research Fellowship

Externally funded competitive fellowships:

  • Israeli Ministry of Science and Technology (1992- 6 months at Weizmann Institute, Israel)
  • Royal Society (1991-1992- 6 weeks at Weizmann Institute, Israel)
  • CIBA Foundation (1986- 1 month at Scripps Institute, San Diego, USA).

Research areas

Professor Perry is Head of the Biomolecular Materials Interface Research Group.

Research Fellows:

  • David Belton
  • Graham Hickman
  • Marion Limo
  • Anna Sola-Rabada

Research Assistant:

Vacancy to be filled shortly

Research Students:

  • Mithun Parambath
  • Anna Sola-Rabada
  • Matthew Nicklin
  • Zayd Westcott
  • Veeru Thota
  • Robyn Plowright
  • One unfilled position

Visitors (academic year 2015-2016):

  • Padma Sahare, PhD student (Mexico) six weeks
  • Dr Olga Verokskina, PDRA (Irkutsk, Russia) three months
  • Masashi Ito, MSc student (Tokyo, Japan) three months
  • Monika Michaels, PhD student (Bremen, Germany) two months
  • Maria Desastre MSc student (Naumur, Belgium) three months

Research is focussed towards understanding what happens at the interface between biomolecules and materials. Current projects include:

  • The study of abiotic biotic interactions at the molecular level between materials such as platinum, zinc oxide and silica and peptides that have been identified by Phage display methods (AFOSR). The studies include identification of peptides that bind to specific minerals (phage display), identification of the structural features in the peptides required for binding (molecular modelling), binding studies of peptides and minerals (solution and solid state studies), thermodynamic studies of binding interactions (QCM-D and ITC), and, investigations of the materials that form (materials characterisation). The end goal is to produce a set of rules that can be used predictively with other materials systems.
  • The design and fabrication of chimeric fusion proteins based on cocoon and spider silk and the study of their interaction to understand design criteria for the generation of novel materials for a wide range of potential applications from health to military via performance sports (NIH and EPSRC).
  • Development of novel nanoparticle antibiotic conjugates with high antimicrobial activity (World Gold Council).
  • Fundamental studies of surfaces, including aspects of superhydrophobicity and flow (EPSRC). An extension of this is studies of how proteins behave on surfaces as the first stage in biomaterial recognition. Studies involve the generation of surfaces as well as detailed time dependent studies of protein conformation and binding on the chosen surfaces (Smith and Nephew).
  • Use of our knowledge of surfaces and protein interactions to generate novel mineralised surfaces for functional transistors, biomaterials and cancer studies.
  • Developing new tissue culture surfaces for use in biomaterials development and cancer studies.
  • Conversion of eggshells to useful products (TSB/ Innovate).
  • Identification of the role that bioavailable silicon species play in health.

Opportunities to carry out postgraduate research towards an MPhil /PhD exist in all the areas identified above. Further information may be obtained from the NTU Graduate School.

External activity

  • Fellow of the Royal Society of Chemistry (FRSC)
  • Fellow of Royal Microscopical Society (FRMS)
  • Chartered Chemist (CChem)
  • Member of the EPSRC College of Referees (2003-)
  • Panel member of DFG Research Council (Germany) (2005, 2006, 2011, 2013)
  • Elected Council member and trustee of the Royal Society of Chemistry (2007-2012)
  • Chair of the RSC audit committee (2009-2011)
  • RSC Member of Disciplinary Committee (2011-14)
  • RSC Member of Research Fund Committee (2013-)
  • Member of steering commitee UK Heads of Chemistry (2005-2012)
  • Chair of the UK Heads of Chemistry (2009-2011)
  • Visiting Professor Université Pierre et Marie Curie (Paris VI) (2002)
  • Gast Professor KIT, Karlsruhe (2012)
  • Research Professor in the Institute of Lasers, Photonics and BioPhotonics at the University of Buffalo, New York (2010-13)
  • Key involvement in the successful application to HEFCE for 'Chemistry the Next Generation' (2005) and 'Chemistry for our Future' (2006).
  • Editorial Board Member: Nature Scientific Reports (2012-); Silicon (2010-); Recent Patents in Nanotechnology (2006-)
  • Company director- SiActive (2009-)

Sponsors and collaborators

Current and recent research is being conducted with the collaboration, funding and / or support of:

Current university collaborations include Southampton University, Limnological Institute, Irkutsk, Mainz University, Scripps Institute, USA, Tufts University, USA, MIT, USA, Harvard University, USA, Akron University, USA, Deakin University, Australia.

Research funding in the period since 2005 includes:

  • British Council/ Mexican Government “Generating high value products form Mexican Horsetail for Biotech Applications” (2015-2016) £50,000
  • Innovate UK “Recovery and Processing of High Value Food and Pharmaceutical Ingredients from Waste Egg Shells” (2016-2017) 800k project £147,000 to NTU
  • AFOSR funds for purchase of Raman spectrometer (2014) $116,400.
  • Extracting high value products from egg shells TSB- Food for life (2014-2015) £55,000
  • NIH ca. Development of silk-silica nanocomposites for dental and bone repair (with Tufts University) 2013-2017 $440,000
  • AFOSR Computational and experimental studies of the abiotic-biotic interface (2013-2015) 510,000$
  • Deriving value from egg shell waste (TSB) 2012-2013 £25000
  • Sharp Industries “synthesis of vanadia coated silica nanoparticles” (2012) £10,000
  • AbVista “stabilisation of novel silicon supplement” coI, (2011) £13,500
  • Biotage “study of SLE materials and wettability” (2011-2013) £120,000
  • World Gold Council “Technological developments involving antibiotics and gold” (2011-2012) £65,000
  • Towards an understanding of Peptide-mineral interaction: a predictive approach, C C Perry, AFOSR (US Airforce) (2009 to 2012), £283,333
  • Biomineralisation, C C Perry, Marie Curie Training Network (2008 to 2012), £227,929
  • Silica-protein nanocomposites for dental repair, D L Kaplan, C C Perry, B Rutherford, NIH (2007 to 2012), $445,230
  • A novel approach to nanoscale materials assembly using bioengineered spider silk fusion proteins: a generic approach, C C Perry, EPSRC EP/E048439/1 (2007 to 2010), £268,248
  • Studies of Osseointegration, C C Perry, Smith and Nephew (2005 to 2010), £34,156
  • Synthetic models for biosilicification, C C Perry, V A Annenkov, Limnological Institute, Irkutsk and others from the University of Helsinki and Institute of Physics and Combustion EU/INTAS (2007 to 2009), £5,953
  • Studies of biosilicification and peptide mineral interactions, C C Perry, AFOSR (2006 to 2009), £250,000
  • Biomineralisation for lithography and microelectronics (Biolitho), C C Perry, EU 6th Framework (2006 to 2009), £133,273
  • Drag reduction and slip at solid-liquid interfaces, G McHale, C C Perry, M I Newton, EPSRC EP/D500826/1 (2005 to 2009) £205,498
  • Enhancing Water Sports Performance, G McHale, C C Perry and M I Newton EPSRC EP/E043097/1 (2007 to 2008), £110,369
  • New biomimetic synthetic polymers and organic-inorganic nanocomposites, C C Perry, Royal Society Joint Project Award (2006 to 2008), £12,000
  • Mechanism of antiperspirant action of aluminium salts, C C Perry, Unilever (2004 to 2008), £65,930
  • Studies of aluminium species in polymeric systems, C C Perry, Unilever (2006 to 2007), £48,000
  • Studies on antiperspirant actives, C C Perry, Unilever (2002 to 2007), £300,500
  • Oxide core shell particles, C C Perry, Qinetiq (2007), £20,000
  • Studies of biosilicification, the role of proteins, carbohydrates and model compounds in structure control, C C Perry, AFOSR (2003 to 2006), $505,980
  • Silibiiotec, C C Perry in project led by Mainz University, EU 5th framework, (2002 to 2005), €199,732
  • Studies of Protein Adsorption on Novel Surfaces, C C Perry, Smith and Nephew (2002 to 2005), £45,000

Publications

Secondary structure transition and critical stress for a model of spider silk assembly, T. Giesa, C.C. Perry and M.J. Buehler, Biomacromolecules, 2015.

The nature of the silicaphilic fluorescence of PDMPO, M. Parambath, Q.S. Hanley, F. J. Martin-Martinez, T. Giesa, M.J. Buehler and C.C. Perry, Physical Chemistry Chemical Physics, 2015.

Thermodynamic Study of Interactions between ZnO and ZnO Binding Peptides Using Isothermal Titration Calorimetry, M.J. Limo and C.C. Perry, Langmuir, 2015.

ZnO Binding Peptides; Smart Versatile Tools for Controlled Modification of ZnO Growth Mechanism and Morphology, M.J. Limo, R. Ramasamy and C.C. Perry, Chemistry of Materials, 2015, 27, 1950-1960.

Prediction of Specific Biomolecule Adsorption on Silica Surfaces as a Function of pH and Particle Size, F.S. Emami, V. Puddu, R.J. Berry, V. Varshney, S.V. Patwardhan, C.C. Perry, H. Heinz, Chemistry of Materials, 2014, 26(19) 5725-5734.

Use of surface chemistry to direct the transition of cancer stem cells, G. Hickman, R.C. Rees, A.G. Pockley, C.C. Perry, Advanced Healthcare Materials, 2015, 4(4) 593-601.

Tunable anisotropy in inverse opals and emerging optical properties, Phillips KR, Vogel N, Hu Y, Kolle M, Perry CC,  Aizenberg J, Chemistry of Materials, 2014, 26, 1622-1628.

Chemistry of aqueous silica nanoparticle surfaces and the mechanism of selective peptide adsorption. Patwardhan SV, Emami FS, Berry RJ, Jones SE, Naik RR, Deschaume O, Heinz, H, Perry CC, Journal of the American Chemical Society, 2012, 134 (14), 6244-6256.

Osteoinductive silk-silica composite biomaterials for bone regeneration. Mieszawska AJ, Fourligas N, Georgakoudi I, Ouhib NM, Belton DJ, Perry CC, Kaplan DL, Biomaterials, 2010, 31 (34), 8902-8910.

Antibiotic mediated synthesis of gold nanoparticles with potent antimicrobial activity and their application in antimicrobial coatings. Rai A, Prabhune A, Perry CC, Journal of Materials Chemistry, 2010, 20 (32), 6789-6798.

Facile fabrication of uniform silica films with tunable physical properties using silicatein protein from sponges. Rai A, Perry CC, Langmuir, 2010, 26 (6), 4152.

From biosilicification to tailored materials: Optimizing hydrophobic domains and resistance to protonation of polyamines. Belton DJ, Patwardhan SV, Annenkov VV, Danilovtseva EN, Perry CC, Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 (16), 5963-5968.

See all of Carole Perry's publications...

Press expertise

  • Nanoparticles
  • Interfacial interactions
  • Silica
  • Biomineralization
  • Biomimetics
  • Extending the life of antibiotics
  • Electron microscopy