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Elisa Tonoli

Elisa Tonoli


School of Science & Technology

Staff Group(s)


Dr Elisa Tonoli is a Lecturer in Molecular Bioscience in the Biosciences department.

Career overview

Dr Tonoli graduated from the University of Milan (Italy) with a BSc in Biological Sciences and MRes-equivalent in Molecular Biology. She worked as Research assistant for 3 years at the IRCCS Fatebenefratelli - National Centre for Alzheimer's and Mental Diseases (Brescia, Italy) and then completed a PhD in Neuroscience at Nottingham Trent University (2020).

Research areas

Dr Tonoli research interests focus on the role of extracellular vesicles (EVs) in physiology and pathology, especially in neurodegenerative disorders but also kidney fibrosis and cancer.

As a Research fellow, she was recently involved in a project aimed at identifying the EVs cargo responsible for Mesenchymal stem cells (MSCs)-mediated neuroprotection, supported by both NTU (Health and Wellbeing Strategic Research Themes - Talent Fellowship Scheme) and Professor Tony Marmont philanthropy fund.

She also collaborated in a project supported by NTU and Mestag Therapeutics (a Cambridge-based company) focused on studying the role of EVs in relation to the phenomenon of immune evasion in cancer.

Since April 2023 she became a full time Lecturer in Molecular Bioscience on a Teaching and Scholarship path.

External activity

Member of Biochemical Society

Member of International Society of Extracellular Vesicles


  1. Atobatele AG, Tonoli E, Vadakekolathu J, Savoca MP, Barr M, Kataria Y, Rossanese M, Burhan I, McArdle S, Caccamo D, Verderio EAM. . Canonical and truncated transglutaminase-2 regulate mucin-1 expression and androgen independency in prostate cancer cell lines. PREPRINT available at Research Square [].
  2. Suanno C, Tonoli E, Fornari E, Savoca MP, Aloisi I, Parrotta L, Faleri C, Cai G, Coveney C, Boocock DJ, Verderio EAM, Del Duca S. Small extracellular vesicles released from germinated kiwi pollen (pollensomes) present characteristics similar to mammalian exosomes and carry a plant homolog of ALIX. Front Plant Sci. 2023 Jan 25;14:1090026.
  3. Tepus M, Tonoli E, Verderio EAM. Molecular profiling of urinary extracellular vesicles in chronic kidney disease and renal fibrosis. Front Pharmacol. 2023 Jan 12;13:1041327.
  4. Tonoli E, Verduci I, Gabrielli M, Prada I, Forcaia G, Coveney C, Savoca MP, Boocock DJ, Sancini G, Mazzanti M, Verderio C, Verderio EAM. Extracellular transglutaminase-2, nude or associated with astrocytic extracellular vesicles, modulates neuronal calcium homeostasis. Prog Neurobiol. 2022 Sep;216:102313.
  5. Wilhelmus MMM, Tonoli E, Coveney C, Boocock DJ, Jongenelen CAM, Brevé JJP, Verderio EAM, Drukarch B. The Transglutaminase-2 Interactome in the APP23 Mouse Model of Alzheimer's Disease. Cells. 2022 Jan 24;11(3):389.
  6. Wu Y, Lyu T, Yue B, Tonoli E; Verderio EAM, Ma, Y, Pan G. Enhancement of tomato plant growth and productivity in organic farming by agri-nanotechnology using nanobubble oxygation. J Agric Food Chem. 2019 Oct 2;67(39):10823-10831.
  7. Savoca MP, Tonoli E, Atobatele AG, Verderio EAM. Biocatalysis by Transglutaminases: A Review of Biotechnological Applications. Micromachines (Basel). 2018 Oct 31;9(11). Review.
  8. Furini G, Schroeder N, Huang L, Boocock D, Scarpellini A, Coveney C, Tonoli E, Ramaswamy R, Ball G, Verderio C, Johnson TS, Verderio EAM. Proteomic profiling reveals the transglutaminase-2 externalization pathway in kidneys post-UUO. J Am Soc Nephrol. 2018 Mar;29(3):880-905.
  9. Di Fede G, Catania M, Maderna E, Ghidoni R, Benussi L, Tonoli E, Giaccone G, Moda F, Paterlini A, Campagnani I, Sorrentino S, Colombo L, Kubis A, Bistaffa E, Ghetti B. Molecular subtypes of Alzheimer's disease. Sci Rep. 2018 Feb 19;8(1):3269.
  10. Benussi L, Ciani M, Tonoli E, Morbin M, Palamara L, Albani D, Fusco F, Forloni G, Glionna M, Baco M, Paterlini A, Fostinelli S, Santini B, Galbiati E, Gagni P, Cretich M, Binetti G, Tagliavini F, Prosperi D, Chiari M, Ghidoni R. Loss of exosomes in progranulin-associated frontotemporal dementia. Neurobiol Aging. 2016 Apr;40:41-9.
  11. Vallino Costassa E, Fiorini M, Zanusso G, Peletto S, Acutis P, Baioni E, Maurella C, Tagliavini F, Catania M, Gallo M, Faro ML, Chieppa MN, Meloni D, D'Angelo A, Paciello O, Ghidoni R, Tonoli E, Casalone C, Corona C. Characterization of Amyloid-β Deposits in Bovine Brains. J Alzheimers Dis. 2016;51(3):875-87.
  12. Gagni P, Cretich M, Benussi L; Tonoli E; Ciani M; Ghidoni R; Santini B; Galbiati E; Prosperi D; Chiari M. Combined mass quantitation and phenotyping of intact extracellular vesicles by a microarray platform. Analytica Chimica Acta. 2016 Jan 1;902:160-7.
  13. Catania M, Di Fede G, Tonoli E, Benussi L, Pasquali C, Giaccone G, Maderna E, Ghidoni R, Tagliavini F. Mirror Image of the Amyloid-β Species in Cerebrospinal Fluid and Cerebral Amyloid in Alzheimer's Disease. J Alzheimers Dis. 2015 Aug 11;47(4):877-81.
  14. Ghidoni R, Flocco R, Paterlini A, Glionna M, Caruana L, Tonoli E, Binetti G, Benussi L. Secretory leukocyte protease inhibitor protein regulates the penetrance of frontotemporal lobar degeneration in progranulin mutation carriers. J Alzheimers Dis. 2014;38(3):533-9.
  15. Benussi L, Rossi G, Glionna M, Tonoli E, Piccoli E, Fostinelli S, Paterlini A, Flocco R, Albani D, Pantieri R, Cereda C, Forloni G, Tagliavini F, Binetti G, Ghidoni R. C9ORF72 Hexanucleotide Repeat Number in Frontotemporal Lobar Degeneration: A Genotype-Phenotype Correlation Study. J Alzheimers Dis. 2014 Jan 1;38(4):799-808.