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Dr Jehan EL-Jawhari

Senior Lecturer

Department of Biosciences, School of Science and Technology

Role

  • Senior lecturer of Biosciences
  • Leading a studentship project focused on exploring the involvement of musculoskeletal stem cells in the blood cancer niche. Additionally, collaborating with fellow cancer researchers at John van Geest Cancer Research Centre to advance new research in the field of cancer immunology.

Research areas

  • The stromal and immune milieu of autoimmune, degenerative, and ageing-related musculoskeletal disorders.
  • Bone marrow niche biology.
  • Cancer Immunology.
  • Cell-based regenerative therapies.

External activity

Associate editor of Molecular Medicine Journal

Member of the British Society for Immunology (BSI)

Fellow of the Institute of Biomedical Science (IBMS)

Publications

A first update on mapping the human genetic architecture of COVID-19.

COVID-19 Host Genetics Initiative.
Nature. 2022 Aug;608(7921):E1-E10. doi: 10.1038/s41586-022-04826-7. Epub 2022 Aug 3.

PMID: 35922517

Bioengineering Approaches for Delivering Growth Factors: A Focus on Bone and Cartilage Regeneration.

Shakoor S, Kibble E, El-Jawhari JJ.
Bioengineering (Basel). 2022 May 20;9(5):223. doi: 10.3390/bioengineering9050223.
PMID: 35621501
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative, Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK.
Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7.
PMID: 35255492

Evaluation of Human Bone Marrow Mesenchymal Stromal Cell (MSC) Functions on a Biomorphic Rattan-Wood-Derived Scaffold: A Comparison between Cultured and Uncultured MSCs.

Ganguly P, El-Jawhari JJ, Vun J, Giannoudis PV, Jones EA.
Bioengineering (Basel). 2021 Dec 21;9(1):1. doi: 10.3390/bioengineering9010001.
PMID: 35049710

Bone Marrow Multipotent Mesenchymal Stromal Cells as Autologous Therapy for Osteonecrosis: Effects of Age and Underlying Causes.

El-Jawhari JJ, Ganguly P, Jones E, Giannoudis PV.
Bioengineering (Basel). 2021 May 17;8(5):69. doi: 10.3390/bioengineering8050069.
PMID: 34067727

The Biological Fitness of Bone Progenitor Cells in Reamer/Irrigator/Aspirator Waste.

El-Jawhari JJ, Ganguly P, Churchman S, Jones E, Giannoudis PV.

J Bone Joint Surg Am. 2019 Dec 4;101(23):2111-2119. doi: 10.2106/JBJS.19.00133.

PMID: 31800424

Defective Proliferation and Osteogenic Potential with Altered Immunoregulatory phenotype of Native Bone marrow-Multipotential Stromal Cells in Atrophic Fracture Non-Union.

El-Jawhari JJ, Kleftouris G, El-Sherbiny Y, Saleeb H, West RM, Jones E, Giannoudis PV.

Sci Rep. 2019 Nov 22;9(1):17340. doi: 10.1038/s41598-019-53927-3.

PMID: 31758052

The Analysis of In Vivo Aging in Human Bone Marrow Mesenchymal Stromal Cells Using Colony-Forming Unit-Fibroblast Assay and the CD45lowCD271+ Phenotype.

Ganguly P, El-Jawhari JJ, Burska AN, Ponchel F, Giannoudis PV, Jones EA.

Stem Cells Int. 2019 Aug 1;2019:5197983. doi: 10.1155/2019/5197983. eCollection 2019.

PMID:31467563

Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients.

Sanjurjo-Rodriguez C, Baboolal TG, Burska AN, Ponchel F, El-Jawhari JJ, Pandit H, McGonagle D, Jones E.

Sci Rep. 2019 Jun 27;9(1):9321. doi: 10.1038/s41598-019-45820-w.

PMID: 31249374

Identification of senescent cells in multipotent mesenchymal stromal cell cultures: Current methods and future directions.

Zhai W, Yong D, El-Jawhari JJ, Cuthbert R, McGonagle D, Win Naing M, Jones E.

Cytotherapy. 2019 Aug;21(8):803-819. doi: 10.1016/j.jcyt.2019.05.001. Epub 2019 May 25. Review.

PMID:31138507

A crosslinked collagen membrane versus a non-crosslinked bilayer collagen membrane for supporting osteogenic functions of human bone marrow-multipotent stromal cells.

El-Jawhari JJ, Moisley K, Jones E, Giannoudis PV.

Eur Cell Mater. 2019 Apr 24;37:292-309. doi: 10.22203/eCM.v037a18.

PMID:31016711

Optimising proliferation and migration of mesenchymal stem cells using platelet products: A rational approach to bone regeneration.

Moisley KM, El-Jawhari JJ, Owston H, Tronci G, Russell SJ, Jones EA, Giannoudis PV.

J Orthop Res. 2019 Jun;37(6):1329-1338. doi: 10.1002/jor.24261. Epub 2019 Mar 28. Erratum in: J Orthop Res. 2019 Sep;37(9):2061.

PMID:30816585

Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data.

RA-MAP Consortium .

RMD Open. 2018 Oct 25;4(2):e000721. doi: 10.1136/rmdopen-2018-000721. eCollection 2018.

PMID:30487994

T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool.

El-Sherbiny YM, El-Jawhari JJ, Moseley TA, McGonagle D, Jones E.

Sci Rep. 2018 Sep 10;8(1):13535. doi: 10.1038/s41598-018-31979-1.

PMID:30201960

Vertebral body versus iliac crest bone marrow as a source of multipotential stromal cells: Comparison of processing techniques, tri-lineage differentiation and application on a scaffold for spine fusion.

Fragkakis EM, El-Jawhari JJ, Dunsmuir RA, Millner PA, Rao AS, Henshaw KT, Pountos I, Jones E, Giannoudis PV.

PLoS One. 2018 May 24;13(5):e0197969. doi: 10.1371/journal.pone.0197969. eCollection 2018.

PMID:29795650

The regenerative therapies of the ankle degeneration: a focus on multipotential mesenchymal stromal cells.

El-Jawhari JJ, Brockett CL, Ktistakis I, Jones E, Giannoudis PV.

Regen Med. 2018 Mar 19. doi: 10.2217/rme-2017-0104. [Epub ahead of print]

PMID:29553890

Age-related Changes in Bone Marrow Mesenchymal Stromal Cells: A Potential Impact on Osteoporosis and Osteoarthritis Development.

Ganguly P, El-Jawhari JJ, Giannoudis PV, Burska AN, Ponchel F, Jones EA.

Cell Transplant. 2017 Sep;26(9):1520-1529. doi: 10.1177/0963689717721201. Review.

PMID:29113463

The CD45lowCD271high Cell Prevalence in Bone Marrow Samples May Provide a Useful Measurement of the Bone Marrow Quality for Cartilage and Bone Regenerative Therapy.

El-Jawhari JJ, Cuthbert R, McGonagle D, Jones E, Giannoudis PV.

J Bone Joint Surg Am. 2017 Aug 2;99(15):1305-1313. doi: 10.2106/JBJS.16.01138.

PMID:28763416

Interleukin-22 drives the proliferation, migration and osteogenic differentiation of mesenchymal stem cells: a novel cytokine that could contribute to new bone formation in spondyloarthropathies.

El-Zayadi AA, Jones EA, Churchman SM, Baboolal TG, Cuthbert RJ, El-Jawhari JJ, Badawy AM, Alase AA, El-Sherbiny YM, McGonagle D.

Rheumatology (Oxford). 2017 Mar 1;56(3):488-493. doi: 10.1093/rheumatology/kew384.

PMID:27940584

The roles of immune cells in bone healing; what we know, do not know and future perspectives.

El-Jawhari JJ, Jones E, Giannoudis PV.

Injury. 2016 Nov;47(11):2399-2406. doi: 10.1016/j.injury.2016.10.008. Review.

PMID:27809990

Collagen-containing scaffolds enhance attachment and proliferation of non-cultured bone marrow multipotential stromal cells.

El-Jawhari JJ, Sanjurjo-Rodríguez C, Jones E, Giannoudis PV.

J Orthop Res. 2016 Apr;34(4):597-606. doi: 10.1002/jor.23070. Epub 2015 Dec 1.

PMID:26466765

Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis.

Churchman SM, El-Jawhari JJ, Burska AN, Parmar R, Goëb V, Conaghan PG, Emery P, Ponchel F.

Arthritis Res Ther. 2014 Dec 23;16(6):511. doi: 10.1186/s13075-014-0511-3.

PMID:25533722

An immunological biomarker to predict MTX response in early RA.

Ponchel F, Goëb V, Parmar R, El-Sherbiny Y, Boissinot M, El Jawhari J, Burska A, Vital EM, Harrison S, Conaghan PG, Hensor E, Emery P.

Ann Rheum Dis. 2014 Nov;73(11):2047-53. doi: 10.1136/annrheumdis-2013-203566. Epub 2013 Aug 29.

PMID:23989988

Mesenchymal stem cells, autoimmunity and rheumatoid arthritis.

El-Jawhari JJ, El-Sherbiny YM, Jones EA, McGonagle D.

QJM. 2014 Jul;107(7):505-14. doi: 10.1093/qjmed/hcu033. Epub 2014 Feb 10. Review.

PMID:24518000

Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes.

El-Jawhari JJ, El-Sherbiny YM, Scott GB, Morgan RS, Prestwich R, Bowles PA, Blair GE, Tanaka T, Rabbitts TH, Meade JL, Cook GP.

Mol Immunol. 2014 Apr;58(2):160-8. doi: 10.1016/j.molimm.2013.11.020. Epub 2013 Dec 22.

PMID:24365750