John Hunt

John Hunt

Professor/Head of NTU Strategic Research Theme

College of Science and Technology

Role

Theme leader and research academic; utilising and building the extensive research power of our University to address what is required from technology and materials in the short, medium and long term. The theme will connect academics with industry and healthcare providers providing the combined integrated approach to addressing future needs through early stage integration.

Career overview

John’s research has focused on developing breakthrough therapies, devices and technology to repair, replace, augment and in the future regenerate diseased, infected and damaged tissues in humans and other mammals using material interventions.

Understanding the generic science to deliver interventional medical therapies requiring the use of a material (living cells are also considered a material). These will come from an in depth generic first principles approach to understanding and directing the patient’s cellular and molecular mechanisms and responses related to the clinical outcome and efficacy of medical devices, biocompatibility, inflammation and stem cell biology.

Tissue engineering processes are developed and applied, addressing the key areas of patient treatments requiring intervention and material implantation. The materials of choice being researched today also include cells and within that, expertise and intellectual property has been created relating to primary cell sourcing, controlling cell function and phenotype through defining and controlling extracellular matrix interactions, angiogenesis, inflammation, and tissue regeneration.

From a strong long lived generic research platform, specific applications and knowledge has been applied to and continue to be developed for musculoskeletal tissues specifically cartilage and bone, visceral and vascular tissues.  Research has been funded by the European Commission, BBSRC, MRC and EPSRC as well as by Industry. Ph.D in 1992 and D.Sc. in 2006.

John has organised seven national and international conferences; the biggest being the European Society for Biomaterials meeting in 2014.

Patents

  1. siRNA therapeutic for canine osteoarthritisInventor: Hunt John A [GB] INNES John [GB] WO 2015/128651 PCT/GB2015/050552. PCT September 2015.
  2. Osteoinductive Materials
    Inventor: HUNT JOHN A [GB]  CURRAN JUDITH M [GB] WO2015/015189. Priority date 2013-07-29.
  3. Patterned surfaces and methods of use for stem cell culture
    Inventor: HUNT JOHN A [GB] CURRAN JUDITH M [GB] (+5)            
    Applicant: NANOINK INC [US] ULIVE ENTPR LTD [GB] (+7)  
    CPC:C12N2533/20 C12N2535/10 C12N5/0075 (+3)
    IPC: C12N5/00 C12N5/077  
    Publication info: WO2011088379 (A1) 2011-07-21
    Priority date: 2010-01-14
  4. Materials and methods for cell growth
    Inventor: HUNT JOHN A [GB] CURRAN JUDITH M [GB] (+2)
    Applicant: ULIVE ENTPR LTD
    CPC: C12N2533/12 C12N2533/14 C12N2535/10 (+2)
    IPC: A61F2/00 C12N11/02 C12N11/14 (+1)
    Publication info: US2010040661 (A1) 2010-02-18
    Priority date: 2008-07-12

Research areas

The Cellular Response to Implanted Materials.

Tissue Engineering in vitro, in vivo and ex vivo.

Medical Materials including living materials (deriving and applying progenitor cells).

Diagnostics and health monitoring

External activity

  • Vice Chairman of the Committee of Analytical Biosciences Group, The Royal Society of Chemistry 2004 –
  • Steering committee member and elected treasurer, International College of Fellows of Biomaterials Science and Engineering (ICF-BSE) 2016 -
  • Athena Swan Review Panel Member 2014-
  • Wellcome Trust Innovations Advisory Group 2012 –
  • Review Committee Biomedical Engineering, Academy of Finland, Biomedical Engineering, Suomen Akatemia / Academy of Finland 2004 –
  • Science, Engineering, Technology and Mathematics Network STEMNET ambassador 2010 -
  • BBSRC review panel committee C member 2009 – 2017
  • EPSRC Review College member 2016 -
  • External Referee of the ERC Consolidator EU Funding Scheme 2012 -
  • Expert Panel member for EU Marie Curie Fellowship Schemes 2012 –
  • Honorary academic at University of Liverpool.
  • International Board Member for Journal Biomaterials 2002 –
  • Subject Editor for Biomaterials and Nanotechnology in International Journal of Artificial Organs 2008 -
  • Reviewer for European Society for Biomaterials, The Swiss National Science Foundation, FNSNF,The British Council in France, The Natural Sciences and Engineering Research Council of Canada, The Irish Research Academy, The Leverhulme Trust, The Wellcome Trust, The Portuguese Science Foundation, Singapore Science and Technology .

Publications

Rogers, E.H. Fawcett, S.A.Pekovic-Vaughan V. Hunt J.A. Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue. Stem Cells International Volume 2017 (2017), https://doi.org/10.1155/2017/2057168

Chen, R. Curran, J.M. Pu, F. Zhuola, Z.A. Bayon, Y. Hunt, J.A. In vitro response of human peripheral blood mononuclear cells (PBMC) to collagen films treated with cold plasma. Polymers Volume 9, Issue 7, 29 June 2017, DOI: 10.3390/polym9070254

Aine Devlin-Mullin, Naomi M. Todd, Zahra Golrokhi, Hua Geng, Moritz A. Konerding, Nigel G. Ternan, John A. Hunt, Richard J. Potter, Chris Sutcliffe, Eric Jones, Peter D. Lee, Christopher A. Mitchell. Atomic Layer Deposition of a Silver Nanolayer on Advanced Titanium Orthopedic Implants Inhibits Bacterial Colonization and Supports Vascularized de Novo Bone Ingrowth. Advanced Healthcare Materials. March 2017. 1700033. DOI: 10.1002/adhm.201700033.

Fawcett S.A. Curran J.M. Chen R. Rhodes N.P. Murphy M.F. Wilson P. Lakshminarayan Ranganath L. Dillon J.A. Gallagher J.A. Hunt J.A. Defining the Properties of an Array of –NH2-Modified Substrates for the Induction of a Mature Osteoblast/Osteocyte Phenotype from a Primary Human Osteoblast Population Using Controlled Nanotopography and Surface Chemistry. Calcif Tissue Int. 2016 DOI 10.1007/s00223-016-0202-y

Czarnecki G. Hunt J.A. Heirloom: Living Portraits of and for the Artist’s Daughters Created out of Their Own Cultured Cells. Leonardo, 2017, Vol. 0, No. ja doi: 10.1162/LEON_a_01357

Battersby C.L. Battersby N.J. Hollyman M. Hunt J.A. Double-Gloving Impairs the Quality of Surgical Knot Tying: A Randomised Controlled Trial. World J Surg. 2016 Nov;40(11):2598-2602.

Maobin Xie, Dejun Fan, Yufeng Chen, Zheng Zhao, Xiaowen He, Gang Li, Aizheng Chen, Xiaojian Wu, Jiashen Lia, Zhi Li, John A. Hunt, Yi Li, Ping Lan. An implantable and controlled drug-release silk fibroin nanofibrous matrix to advance the treatment of solid tumour cancers. Biomaterials 2016, (103), Oct, 33–43 doi:10.1016/j.biomaterials.2016.06.049

Gee E.C. Jordan R. Hunt J.A. Saithna A Current Evidence and Future Directions for Research into the use of Tantalum in Soft Tissue Re-attachment. Journal of Materials Chemistry B, 2016, doi: 10.1039/C5TB01786F.

Theologou T. Exarchou K. Bermingham H. Chan B. Morton D. Hunt J.A. The 50th Congress of the European Society for Surgical Research. June 10-13, 2015, Liverpool, United Kingdom: Full conference proceedings:EurSurg Res 2015;55(suppl 1):1-167. doi:10.1159/000381839.

Smart N.J. Bryan N. Hunt J.A. Daniels I.R. Porcine dermis implants in soft-tissue reconstruction. Biologics. 2014 Mar 10(8) 83-90. doi: 10.2147/BTT.S46469.

Khattak M. Pu F. Curran J.M. Hunt J.A. D'Sa R.A. Human mesenchymal stem cell response to poly(ε-caprolactone/poly(methyl methacrylate) demixed thin films.J Mater Sci Mater Med. 2015 May;26(5):5507. doi: 10.1007/s10856-015-5507-2. Epub 2015 Apr 17

Bryan N, Ashwin H, Smart NJ, Wohlert S, Bayon Y, Hunt JA. Characterisation and comparison of the host response of 6 tissue-based surgical implants in a subcutaneous in vivo rat model. J ApplBiomaterFunct Mater. 2015 Mar 18;13(1). doi: 10.5301/jabfm.5000172.

Percival S.L. McCarty S. Hunt J.A. Woods E.J. The Role of pH IN Healing, Biofilm Formation and Antimicrobial Management of Wounds. Wound Repair and Regeneration. 2014. 22(2) 174-186. DOI: 10.1111/wrr.12125.

van Veen T, Hunt JA.Tissue engineering red blood cells: a therapeutic.J Tissue Eng Regen Med. 2014 Apr 21. doi: 10.1002/term.1885.

Bryan N, Battersby C, Smart N, Hunt J.A. A review of biocompatibility in hernia repair; considerations in vitro and in vivo for selecting the most appropriate repair material.Hernia. 2015 Apr;19(2):169-78. doi: 10.1007/s10029-014-1307-8. Epub 2014 Sep 13.

Battersby CL, Bryan N, Hunt JA. Effect of Simvastatin on Physiological and Biological Outcomes in Patients Undergoing Esophagectomy: A Randomized Placebo-Controlled Trial.Ann Surg. 2014 Mar 25.

Pu F, Rhodes NP, Bayon Y, Hunt JA.In vitro cellular response to oxidized collagen-PLLA hybrid scaffolds designed for the repair of muscular tissue defects and complex incisional hernias.J Tissue Eng Regen Med. 2013 Nov 15. doi: 10.1002/term.1837.

Smart NJ, Bryan N, Hunt JA, Daniels IR.Porcine dermis implants in soft-tissue reconstruction: current status.Biologics. 2014 Mar 10;8:83-90. doi: 10.2147/BTT.S46469. eCollection 2014.

Percival SL, McCarty S, Hunt JA, Woods EJ.The effects of pH on wound healing, biofilms, and antimicrobial efficacy.Wound Repair Regen. 2014 Mar-Apr;22(2):174-86. doi: 10.1111/wrr.12125. Epub 2014 Feb 24.

Bryan N, Ashwin H, Smart N, Bayon Y, Wohlert S, Hunt JA. The in vivo evaluation of tissue-based biomaterials in a rat full-thickness abdominal wall defect model. J Biomed Mater Res B ApplBiomater. 2013 Oct 24. doi: 10.1002/jbm.b.33050

Bryan N, Ashwin H, Chen R, Smart NJ, Bayon Y, Wohlert S, Hunt JA. Evaluation of six synthetic surgical meshes implanted subcutaneously in a rat model.J Tissue Eng Regen Med. 2013 Oct 7. doi: 10.1002/term.1807

Curran JM, Fawcett S, Hamilton L, Rhodes NP, Rahman CV, Alexander M, Shakesheff K, Hunt JA. The osteogenic response of mesenchymal stem cells to an injectable PLGA bone regeneration system.Biomaterials. 2013 Dec;34(37):9352-64. doi: 10.1016/j.biomaterials.2013.08.044.

Hunt JA, Fok M, Bryan N. Impact of cell purification technique of autologous human adult stem cells on inflammatory reaction.Biomaterials. 2013 Oct;34(31):7626-31

Bryan N, Lewis FC, Bond D, Stanley C, Hunt JA.Evaluation of a novel non-destructive catch and release technology for harvesting autologous adult stem cells.PLoS One. 2013, 8(1):e53933. doi: 10.1371/journal.pone.0053933. Epub 2013 Jan 22

Cachinho SC, Pu F, Hunt JA. Cytokine secretion from human peripheral blood mononuclear cells cultured in vitro with metal particles. J Biomed Mater Res A. 2013 Apr;101(4):1201-9. doi: 10.1002/jbm.a.34410. Epub 2013 Jan 24.

Bryan N, Ashwin H, Smart N, Bayon Y, Scarborough N, Hunt JA. The innate oxygen dependant immune pathway as a sensitive parameter to predict the performance of biological graft materials.Biomaterials. 2012 Sep;33(27):6380-92. doi: 10.1016/j.biomaterials.2012.05.058. Epub 2012 Jun 26.

Lewis F.C. Bryan N. Hunt J.A. A Feeder-Free, Human Plasma-Derived Hydrogel for Maintenance of a Human Embryonic Stem Cell Phenotype In Vitro. Cell Regeneration 2012, 1:6.doi:10.1186/2045-9769-1-6.

Chen R. Bayon Y. Hunt J.A. Preliminary study on the effects of ageing cold oxygen plasma treated PET/PP with respect to protein adsorption. Colloids Surf B Biointerfaces. 2012 Aug 1;96:62-8. Epub 2012 Apr 6.

Bryan N. Birch P. Stanley C. Bond D. Hunt J.A. The use of acoustic force capture to ultra-purify lymphocyte subpopulations from human adult whole blood. J Tissue Eng Regen Med. 2012 Mar 21. doi: 10.1002/term.1474. [Epub ahead of print].

Bryan N. Ahswin H. Smart N.J. Bayon Y. Hunt J.A. In vitro activation of human leukocytes in response to contact with synthetic hernia meshes. Clin Biochem. 2012 Jun;45(9):672-6. Epub 2012 Mar 9.

Navarro M. Pu. F. Hunt J.A. The Significance of the Host Inflammatory Response on the Therapeutic Efficacy of Cell Therapies Utilising Human Adult Stem Cells. Experimental Cell Research. 2012 318(4)361-70. http://dx.doi.org/10.1016/j.yexcr.2011.12.006

Bryan N, Ashwin H, Smart N, Bayon Y, Wohlert S, Hunt JA. Reactive oxygen species (ROS)--a family of fate deciding molecules pivotal in constructive inflammation and wound healing.Eur Cell Mater. 2012 Sep 24;24:249-65.

Taylor A.M. Boyde A. Wilson P.J.M. Jarvis J.C. Davidson J.S. Hunt J.A. Ranganath L.R. & Gallagher J.A. The Role of Calcified Cartilage and Subchondral Bone in the Initiation and Progression of OchronoticArthropathy in Alkaptonuria Arthritis and Rheumatism 2011 63(12) 3887-3896.  doi: 10.1002/art.30606.

Curran J.M. Pu F. Chen R. Hunt J.A.The use of dynamic surface chemistries to control MSC isolation and function. Biomaterials. 2011 Jul;32(21):4753-60.http://dx.doi.org/10.1016/j.biomaterials.2011.03.045

Halfhide C.P. Flanagan B.F. Brearey S.P. Hunt J.A. Fonceca A.M. McNamara P.S. Howarth D. Edwards S. Smyth R.L. Respiratory Syncytial Virus binds and undergoes transcription in neutrophils in the blood and airways of infants with severe bronchiolitis. Journal of Infectious Diseases 2011 204 451-458.

Rhodes N.P. Hunt J.A. Longinotti C. Pavesio A. In Vivo Characterization of Hyalonect, a Novel Biodegradable Surgical Mesh.Journal of Surgical Research, J Surg Res. 2011 Jun 1;168(1):e31-8. Epub 2010 Oct 8.

Bryan N, Andrews K, Loughran MJ, Rhodes NP, Hunt JA Elucidating the Contribution of the Elemental Composition of Fetal Calf Serum Towards Antigenic Expression of Primary Human Umbilical Vein Endothelial Cells In Vitro. Biosci Rep. 2011 31(3) 199-210.

Curran J.M. Stokes R. Irvine E. Graham D. Amro N.A. Sanedrin R.G. Jamil H. and Hunt J.A. Introducing dip pen nanolithography as a tool for controlling stem cell behaviour: unlocking the potential of the next generation of smart materials in regenerative medicine Lab on a Chip 2010 10 1662-1670doi:10.1039/c004149a

Alves C.M. Reis R.L. Hunt J.A.  The dynamics, kinetics and reversibility of protein adsorption onto the surface of biodegradable materials Soft Matter 2010 6(17) 4135-4143.

Alves C. Reis R. Hunt J.A. The Competitive Adsorption of Human Proteins onto Natural-Based Biomaterials.  J. R. Soc. Interface2010.7(50) 1367-1377.

Pu F, Rhodes NP, Bayon Y, Chen R, Brans G, Benne R, Hunt JA The use of flow perfusion culture and subcutaneous implantation with fibroblast-seeded PLLA-collagen 3D scaffolds for abdominal wall repair Biomaterials. 2010 May;31(15):4330.

Curran J.M. Chen R. Hunt J.A. Material Induced Mesenchymal Stem Cell Differentiation. Biomaterials 2010 31 1463-1464 doi:10.1016/j.biomaterials.2009.12.001  

Donegan GC, Hunt JA, Rhodes N.P. Investigating the importance of flow when utilizing hyaluronan scaffolds for tissue engineering.Journal of Tissue Engineering and Regenerative Medicine2010 4(2),83 – 95.

Curran J.M. Chen R. Stokes R. Irvine E. Graham D. Gubbins E. Delaney D Amro N. Sanedrin R. Jamil H. Hunt J.A. Nanoscale definition of substrate materials to direct human adult stem cells towards tissue specific populations.Journal of Materials Science: Materials in Medicine 2010 21(3) 1021. doi:10.1007/s10856-009-3976-x

O'Hare, P., Meenan, B.J., Burke, G.A., Byrne, G., Dowling, D., Hunt, J.A. Biological responses to Hydroxyapatite surfaces deposited via a co-incident microblasting technique. Biomaterials 2010, 31(3) 515-522. doi:10.1016/j.biomaterials.2009.09.067

Halfhide C. P. Brearey S.P. Flanagan B.F. Hunt J.A. Howarth D. Cummerson J. Edwards S. Hart C.A. Smyth R.L. Neutrophil TLR4 protein expression is reduced in the airways of infants with severe bronchiolitis. Thorax. 2009 Sep;64(9):798-805.

Curran, J.M. Tang, Z. Hunt, J.A. PLGA doping of PCL affects the plastic potential of human mesenchymal stem cells, both in the presence and absence of biological stimuli. Journal of Biomedical Materials Research Part A, 2009 89(1) 1 -12. Doi: 10.1002/jmb.a.31966

Bryan N, Rhodes N.P.Hunt J.A. Derivation and performance of an entirely autologous injectable hydrogel delivery system or cell-based therapies. Biomaterials 2009, Jan;30(2) 180-188. doi:10.1016/j.biomaterials.2008.09.003

Hunt J.A. Regenerative medicine: Materials in a cellular world. Nature Materials 2008, Aug;7(8), 617-8. doi:10.1038/nmat2242

Human Adipose Precursor Cells Seeded on Hyaluronic Acid-Based (HYAFF TM 11) Spongy Scaffolds: a Pilot Clinical Trial. Stillaert F. Hunt J.A. Rhodes N.P. Di Bartolo C. Tognana E. Monstrey S. Blondeel P. Biomaterials2008, 29(29), October, 3953-3959 doi:10.1016/j.biomaterials.2008.06.005

Andrews K.D.Feugier P. Black, R.A. Hunt J.A. Vascular Prostheses: Performance Related to Cell-Shear Responses. Journal of Surgical Research, 2008, 149(1), September, 39-46. doi:10.1016/j.jss.2007.08.030

Hunt J.A. Callaghan J.T.Polymer-Hydroxyapatite Composite versus Polymer Interference Screws in Anterior Cruciate Ligament Reconstruction in a Large Animal Model. Knee Surgery, Sports Traumatology, Arthroscopy. 2008. 16, 655-660 doi:10.1007/s00167-008-0528-8

Baldwin L, Hunt JA. The in vivo cytokine release profile following implantation. Cytokine 2008, 41, 217-222.doi:10.1016/j.cyto.2007.11.015

Rhodes NP, di Bartolo C, Bellini D, Hunt JA. Induction of adipose tissue regeneration by chemically-modified hyaluronic acid. International Journal of Nano and Biomaterials 2008. 1, 250-262.

Andrews K.D. Hunt J.A. Upregulation of Matrix and Adhesion Molecules Induced by Controlled Topography. Materials in Medicine 2008, 19,1601-1608. Doi: 10.1007/s10856-008-3377-6

Andrews K.D. Black, R.A. Hunt J.A. The Technology of Electrostatic Spinning for Tissue Engineering Scaffolds.  Polymer International 2008, 57, 203-210.doi: 10.1002/pi.2317

Dennis von Heimburg, KarstenHemmrich, Nicholas P. Rhodes, John A. Hunt, Chiara Di Bartolo, Norbert Pallua, and Phillip Blondeel. Autologous in vivo adipose tissue engineering in hyaluronan-based gels in a pig model. Journal of Surgical Research 2008, 144, 82-88. doi:10.1016/j.jss.2007.03.017

Hunt J.A. The Criticality of Quantitative Analysis and Reproducibility for the Development of Interactive Regenerative Treatments. Biomaterials, 2007, 28, 5128-5130. doi: 10.1016/j.biomaterials.2007.07.016  

R. Chen J.A. Hunt.Biomimetic Materials Processing for Tissue Engineering Processes. Journal of Materials Chemistry, 2007, 17, 3974 – 3979.doi: 10.1039/b706765h

A.McGee, J. A. Hunt. Bone Regeneration in a Bi-Lateral Sinus Lift; a Comparative Pilot Case Study Between Irradiated Human Cancellous Bone Versus a Synthetic Analogue. European Journal for Dental Implantologists. 2007, 3, 54-57.

D.M. Warde. S.E. Herrick. J.A. Hunt. Autologous Fat Transplantation and Adipose Tissue in Tissue Engineering. International Journal of Adipose TissueVol1(1): 42-48.  2007.

Rhodes, N.P. Di Bartolo, C. Hunt, J.A. Analysis of the Cellular Infiltration of Benzyl-Esterified Hyaluronan Sponges Implanted in Rats Biomacromolecules,2007,8 (9), 2733 -2738; doi: 10.1021/bm070368p

Tang Z.G. Rhodes N.P. Hunt J.A. Control of the domain microstructures of PLGA and PCL binary systems: Importance of morphology in controlled drug release. Trans IChemE, Part A, Chemical Engineering Research and Design, 2007, Vol85(A7): 1044–1050. doi:10.1205.cherd06217

Mirsadraee s. Wilcox H.E. Watterson K.G. Kearney J.N. Hunt J.A. Fisher J. Ingham E. Biocompatibility of acellular human pericardium. Journal of Surgical Research 2007,143, 407-414.doi:10.1016/j.jss.2007.01.026

M. Oates, R. Chen, M. Duncan, J.A. Hunt. The Angiogenic Potential of Three Dimensional Open Porous Synthetic Matrix Materials. BiomaterialsVol28: 3679-3686. 2007.doi:10.1016/j.biomaterials.2007.04.042

K.D. Andrews, J.A. Hunt, R.A. Black. An Investigation into the Effects of Sterilisation on the Physical Properties of Electrostatically Spun Scaffolds. Biomaterials Vol28: 1014-1026.2007.doi:10.1016/j.biomaterials.2006.10.014

Marina Brama, Nicholas Rhodes, John Hunt, Andrea Ricci, Silvia Migliaccio, Carlo Della Rocca,Roberto Teghil, Silvia Leccisotti, Attilio Lioi, Marta Scandurra, Giovanni De Maria, Daniela Ferro, Fanrong Pu, Laura Politi and Roberto Scandurra. Effect of titanium carbide coating on the osseointegration response in vitro and in vivo. Biomaterials Vol28: 595-608.2007.doi:10.1016/j.biomaterials.2006.08.018

Baldwin L. Hunt J.A. The inflammatory response to NiCr, CoCr and Ti upon implantation in Rats. J. Biomed. Materials Res.Vol79: 574-581. 2006.doi:10.1002/jbm.a.30856

Curran J.M. Chen R. Hunt J.A.The Guidance of Human Mesenchymal Stem Cell Differentiation in vitro by Controlled Modifications to the Cell Substrate. Biomaterials,Vol27,4783-4793. 2006.doi:10.1016/j.biomaterials.2006.05.001

Richardson S.M. Walker R.V. Parker S. Rhodes N. Hunt J.A. Freemont A.J. Hoyland J.A. Intervertebral Disc Cell Mediated Mesenchymal Stem Cell Differentiation. Stem Cells Vol 24: 707-716  2006.doi: 10.1634/stemcells.2005-0205

R. Chen, S. J. Curran, J. M. Curran, J. A. Hunt. The use of Poly(L-Lactide) and RGD Modified Microspheres as Cell Carriers in a Flow Intermittency Bioreactor for Tissue Engineering Cartilage. Biomaterials, Vol27, 4453-4460.2006.doi:10.1016/j.biomaterials.2006.04.011

Tang Z.G. Hunt J.A. The Effect of PLGA doping of polycaprolactone films on the control of osteoblast cell adhesion and proliferation in vitro. Biomaterials,Vol27, Issue 4409-4418. 2006.doi:10.1016/j.biomaterials.2006.04.009

Richardson, S.M. Curran, J.M. Chen, R. Vaughan-Thomas, A. Hunt, J.A. Freemont, A.J. and Hoyland, J.A. The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-l-lactic acid (PLLA) scaffolds. Biomaterials,Vol27, Issue 4069-4078. 2006.doi:10.1016/j.biomaterials.2006.03.017

K. Fujiyoshi and J.A. Hunt. The Effect of Particulate Material on the Regulation of Chemokine Receptor Expression in Leukocytes. Biomaterials Vol27 3888-3896. 2006.doi:10.1016/j.biomaterials.2006.02.047

Rhodes, N.P. Bellón, J.M. Buján, J. Soldani, G. Hunt, J.A. Inflammatory Response to a Novel Series of Siloxane-Crosslinked Polyurethane Elastomers Having Controlled Biodegradation.Journal of Materials Science: Materials in Vol16(12) 1207 – 1211. 2005.doi: 10.1007/s10856-005-4730-7

Marques, A.P. Reis, R.L. Hunt, J.A. The effect of starch-based biomaterials on leukocyte adhesion and activation in vitro.Journal of Materials Science: Materials in Vol16(11) 1029 – 1043. 2005.doi: 10.1007/s10856-005-4757-9

Curran, S.J. Chen, R. Curran, J.M. Hunt, J.A. Expansion of Human Chondrocytes in an Intermittent Stirred Flow Bioreactor Using Modified Biodegradable Microspheres. Tissue Eng. September/October;11(9-10):1312-1322. 2005.doi: 10.1089/ten.2005.11.1312

Tang Z.G Callaghan J.T. Hunt J.A. The Physical Properties and Response of Osteoblasts to Solution Cast Films of PLGA Doped Polycaprolactone. Biomaterials Vol26 6618-6624. 2005.doi:10.1016/j.biomaterials.2005.04.013

Marques, A. P. Reis, R. L. Hunt, J. A.In Vivo study of the Host Response to Starch-Based Polymers and Composites Subcutaneously Implanted in Rats. Macromolecular Bioscience. Volume 5(8) 775 - 785. 2005.doi: 10.1002/mabi.200500010

Curran, J.M. Chen, R. Hunt, J.A. Controlling the phenotype and function of mesenchymal stem cells in vitro by adhesion to silane modified clean glass surfaces. Biomaterials Vol26 7057-7067. 2005.doi:10.1016/j.biomaterials.2005.05.008

Hunt, J.A. Callaghan, J.T. Sutcliffe, C.S. Morgan, R.H. Halford, B. Black, R.A. Osseointegration of CoCr alloy implants with 3D surface topography defined by CAD-CAM. Biomaterials Vol26, 5890-5897. 2005.doi:10.1016/j.biomaterials.2005.03.004

Al-Badairy, H. Tatlock, G. Fawcett, S. Beahan, P. Hunt, J. FEG-SEM Investigation of α-alumina Scales Formed on FeCrAlYAloys Oxidised at 12000 C.  J. Phys. IV France. Vol124 17-24. 2005.

Baldwin, L. Flanagan, B.F. Hunt, J.A. Flow Cytometric Measurement of Phagocytosis Reveals a Role for C3b in Metal Particle Uptake by Phagocytes. J. Biomed. Materials Res. Vol73(1) 80-85. 2005.doi: 10.1002/jbm.a.30252

Curran J.M. Gallagher,J.A. Hunt, J.A. The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture. Biomaterials, Vol26 5313-5320. 2005.doi:10.1016/j.biomaterials.2005.01.065

Feugier, P. Black, R.A. Hunt, J.A. How, T.V.  Attachment, morphology and adherence of human endothelial cells to vascular prosthesis materials under the action of shear stress. BiomaterialsVol26,1457-1466. 2005.doi:10.1016/j.biomaterials.2004.04.050

Marques, A. P. Reis, R. L. Hunt, J. A.Cytokine secretion from mononuclear cells cultured in vitro with starch-based polymers and poly-L-lactide. J. Biomed. Materials Res. Vol71(3), 419-429 2004.doi: 10.1002/jbm.a.30155

Jackson,P.V. Hunt, J.A. Doherty, P.J.  Cannon, A. Gilson, P.Hydrophilicity of 3-D biomaterials: The Washburn equation. Journal of Materials Science: Materials in Medicine, Vol15, 507-511. 2004.doi: 10.1023/B:JMSM.0000021129.60818.ca

Tang, Z.G. Black, R.A.  Curran, J.M. Hunt, J. A. Rhodes, N.P. Williams, D.F. Surface Properties and Biocompatibility of Solvent-cast Poly[ε-caprolactone] Films, Biomaterials Vol 25, 4741-4748. 2004.doi:10.1016/j.biomaterials.2003.12.003

Vallabhaneni SR, Gilling-Smith GL, Brennan JA, Heyes RR, Hunt JA, How TV, Harris PL.  Can monitoring of       intrasac pressure accurately predict failure of endovascular aneurysm?  Journal of Endovascular Therapy.  2003. 10:524-530.doi: 10.1583/1545-1550(2003)010<0524:CIPMRP>2.0.CO;2

Rice, J.M. Hunt, J.A. Gallagher,J.A. Hanarp, P. Sutherland, D.S. Gold, J. Quantitative assessment of the response of primary derived human osteoblasts and macrophages to a range of nanotopography surfaces in a single culture model in vitro.,Biomaterials, Vol24, Issue 26, 4799-4818. 2003.doi:10.1016/S0142-9612(03)00381-8

Alves, C.M. Reis, C.M. Hunt, J.A. Preliminary study on human protein adsorption and leukocyte adhesion to starch based biomaterials. J. of Materials Science: Materials in Medicine, Vol14, 157-165. 2003.doi: 10.1023/A:1022023930825

Marques, A.P. Reis, R.L. Hunt, J.A. Evaluation of the potential of starch-based biodegradable polymers in the activation of human inflammatory cells, Journal of Materials Science: Materials in Medicine, Vol14, 167-173. 2003.doi: 10.1023/A:1022028114896

Rice, J.M. Hunt, J.A. Gallagher,J.A. Quantitative evaluation of the biocompatible and osteogenic properties of a range of biphasic calcium phosphate (BCP) granules using primary cultures of human osteoblasts and monocytes. Calcified Tissue International,Vol72, 6,1. 726-736. 2003. doi: 10.1007/s00223-002-2045-y

Hunt, J.A. and ShoichetM. S. Biomaterials: drug delivery systems, Current Opinion in Solid State & Materials Science. Vol6, 281.2002.doi:10.1016/S1359-0286(02)00115-8

Swindle, E,J, Hunt J.A. Coleman,J.W. A comparison of reactive oxygen species generation by rat peritoneal macrophages and mast cells using the highly sensitive real-time chemiluminescent probe Pholasin; inhibition of antigen-induced mast cell degranulation by macrophage-derived hydrogen peroxide.Journal of Immunology.Vol169(10):5866-5873. 2002.

Pu, F.R. Williams, R.L. Markkula, T. Hunt J.A. Expression of Leukocyte-Endothelial Cell Adhesion Molecules on Monocyte Adhesion to Human Endothelial Cells on Plasma Treated PET and PTFE in vitro.Biomaterials Vol23, 4705-4718 2002.doi:10.1016/S0142-9612(02)00219-3

Baldwin, L. Flanagan, B.F. McLaughlin, P.J. Parkinson, R.W. Hunt, J.A. Williams, D.F. A study of interface membranes from revision accord knee arthroplasty: the role of T lymphocytes. Biomaterials Vol 23,3007-3014.2002.doi:10.1016/S0142-9612(02)00059-5

Pu, F.R. Williams, R.L. Markkula, T. Hunt J.A. Effect of plasma treated PET and PTFE on expression of adhesion molecules by human endothelial cells in vitro.Biomaterials Vol23,2411-2428.  2002.doi:10.1016/S0142-9612(01)00377-5

Marques, A.P. Reis, R.L. Hunt, J.A. The biocompatibility of novel starch based polymers and composites: in vitro studies. Biomaterials. Vol23, 1471-1478. 2002.doi:10.1016/S0142-9612(01)00272-1

Pu, F.R. Williams, R.L. Markkula, T. Hunt, J.A. Monocyte Adhesion and Adhesion Molecule Expression on Human Endothelial cells on Plasma Treated PET and PTFE in Vitro. Materials in Medicine Vol. 12, 971-977. 2001.doi: 10.1023/A:1012861116388

Markkula, T.K. Hunt, J.A. Pu, F.R. Williams, R.L. Surface Chemical Derivatisation of Plasma Treated PET and PTFE. Surface and Interface Analysis (SIA),Vol34, 583-58. 2002.doi: 10.1002/sia.1365

Hunt, J.A.  Shoichet, M. Biomaterials: surface interactions. Current Opinion in Solid State & Materials Science, Vol. 5 Issues 2-3, April - June 161-162. 2001.doi:10.1016/S1359-0286(01)00012-2

Hemingway, R. Williams, R.L. Hunt, J.A. Rudge, S.J. The Influence of Bracket type on the force delivery of Ni-TiArchwires. European Journal of Orthodontics Vol23, 233-241. 2001.doi: 10.1093/ejo/23.3.233

Briggs. M.C. Greirson, I. Hiscott, P. Hunt, J.A. Active Scatter Factor (HGF/SF) in ProliferativeVitroretinal Disease.  Invest. Opthalmol Vis. Sci. Vol41:10, September, 3085-3094. 2000.

Davey, P.C. Zuzel, M. Kamiguti, A.S. Hunt, J.A. Aziz, K.A. Activation Dependant Proteolytic Degradation of Polymorphonuclear CD11b. British Journal of Haematology.  Vol. 111, 934-942. 2000.doi: 10.1046/j.1365-2141.2000.02401.x

Frontiers in biomedical polymer applications. Hunt J.A. Materials Today1999,2 (1) 22-23.doi: 10.1016/S1369-7021(99)80036-4

Ramshaw J.A.M. Casagranda, F. White, J.F. Edwards, G.A. Hunt, J.A. Williams, D.F. Werkmeister, J.A.  Effects of Mesh Modification on the Structure of a Mandrel Grown Biosynthetic Vascular Prosthesis.  J. Biomed. Materials Res. Vol. 47, 309-315. 1999.doi: 10.1002/(SICI)1097-4636(19991205)47:3<309::AID-JBM4>3.0.CO;2-R

Werkmeister, J.A. Edwards, G.A. White, J.F. Casagranda, F. Hunt, J.A. Williams, D.F. Ramshaw, J.A.M.  In vivo Evaluation of Modified Mandrel Grown Vascular Prostheses. J. Biomed. Materials Res. Vol. 47, 316-323. 1999.doi: 10.1002/(SICI)1097-4636(19991205)47:3<316::AID-JBM5>3.0.CO;2-W

Hunt, J.A. Using Computer Based Systems for Biomaterial Evaluation. Editorial, Medical Device Technology, Vol. 10, No 7, 20-23, 1999.

Harrington, P.M. Newton, D.J. Williams, C.M.M. Hunt, J.A. Dearman, R.J. Kimber, I. Coleman, J.W. Flanagan, B.F. Eotaxin and eotaxin receptor (CCR3) expression in sephadex particle induced rat lung inflammation. International Journal of Experimental Pathology. Vol. 80, 177-185, 1999.doi: 10.1046/j.1365-2613.1999.00112.x

Hunt, J.A. Howlett, C.R. Zicat, B. Williams, D.F. Zreiqat, H. Quantification of the Bone Related mRNAs at the Bone/Prosthetic Interface. Journal Materials Science: Materials in Medicine, 1998; 9:691-694.doi: 10.1023/A:1008930331180

Cartmell, S.H. Doherty, P.J. Hunt, J.A. Healy, D.M. Gilchrist, T. Soft Tissue Response to Glycerol Suspended Controlled Release Glass Particulate. Journal Materials in Medicine, 1998,9:773-777.doi: 10.1023/A:1008923523428

Rice, J.M. Fisher, A.C. Hunt, J.A. Macrophage Polymer Interactions. Polymer special Cells & Materials Issue J. Biomater. Sci. Polymer Edn.1998; 9: 833-847.

Cartmell, S.H. Doherty, P.J. Rhodes, N.P. Hunt, J.A. Healy, D.M. Gilchrist, T.  Haemocompatibility of Controlled Release Glass. Journal Materials Science: Materials in Medicine, 1998; 9:1-7.doi: 10.1023/A:1008830025416

Hunt, J. A. McLaughlin, P.J. Flanagan, B.F. Host response to implanted biomaterials: Techniques to investigate cellular and molecular interactions. Biomaterials 1997; 18: 1449-1459.doi:10.1016/S0142-9612(97)00091-4

Rhodes, N.P. Hunt, J.A. Williams, D.F. Macrophage subpopulation differentiation by stimulation with biomaterials. Journal of Biomedical Materials Research 1997; 37: 481-488.doi: 10.1002/(SICI)1097-4636(19971215)37:4<481::AID-JBM6>3.0.CO;2-H

Hunt JA. Meijs G. Williams D.F. Hydrophillicity of Polymers and Soft Tissue Responses:  A Quantitative Analysis.  Journal of Biomedical Materials Research 1997; 36: 542-549.doi: 10.1002/(SICI)1097-4636(19970915)36:4<542::AID-JBM13>3.0.CO;2-C

Hunt JA. Rhodes NP. Williams DF. Flow Cytometry in the Assessment of Biocompatibility. Cellular Engineering 1996; 1: 209-223.

Campoccia D. Hunt JA. Doherty PJ. Zhong SP. Oregan M. Benedetti L. Williams DF. Quantitative Assessment of the Tissue-Response to Films of Hyaluronan Derivatives. Biomaterials 1996; 17: 963-975.doi:10.1016/0142-9612(96)84670-9

Hunt JA. Flanagan BF. McLaughlin PJ. Strickland I. Williams DF. The Effect of Biomaterial Surface Charge on the Inflammatory Response: Evaluation of Cellular Infiltration and TNFα Production. Journal of Biomedical Materials Research 1996; 31: 139-144. DOI: doi: 10.1002/(SICI)1097-4636(199605)31:1<139::AID-JBM15>3.0.CO;2-I

Gray MR. Darnton SJ. Hunt JA. Irlam RW. Nemeth J. Wallace, HM. Accelerated gastric epithelial proliferation. Gut 1995; 36: 522-527.

Hunt JA. Williams DF. Quantifying the Soft Tissue Response to Implanted Materials. Biomaterials 1995; 16:167-170.doi:10.1016/0142-9612(95)92113-K

Hunt JA. Rhodes NP. Williams DF. Analysis of the Inflammatory Exudate Surrounding Implanted Polymers using Flow Cytometry. Journal Materials Science: Materials in Medicine, 1995; 6:839-843.doi: 10.1007/BF00134328

Hunt JA. Tavakoli SM. Williams RL. Riches ST.  Laser Surface Modification of Polymers to Improve Biocompatibility.  Journal of Materials Science: Materials In Medicine 1995; 6: 813-817.doi: 10.1007/BF00134323

Williams RL. Hunt JA. Tengvall P. Fibroblast Adhesion onto Methyl-Silica Gradients With and Without Preadsorbed Protein. Journal of Biomedical Materials Research, 1995; 29: 1545-1555.doi: 10.1002/jbm.820291211

Rhodes NP. Hunt JA. Williams DF.  Quantification of the Host Response to Implanted Polymers in vivo by Flow Cytometry. Journal of Materials Science: Materials in Medicine 1994; 5: 666-670.doi: 10.1007/BF00120353

Burthem J. Baker PK. Hunt JA. Cawley JC.  Hairy Cell interactions with extracellular matrix: Expression of specific integrin Receptors and their role in the cell's response to specific adhesive proteins.  Blood 1994; 84: 873-881.http://bloodjournal.hematologylibrary.org/cgi/reprint/84/3/873

Burthem J. Baker PK. Hunt JA. Cawley JC.  The Function of c-fms in hairy cell leukaemia: Macrophage Colony Stimulating Factor Stimulates Hairy Cell Movement. Blood 1994; 83: 1381-1389. http://bloodjournal.hematologylibrary.org/cgi/reprint/83/5/1381

Hunt JA. Williams DF. Ungersbock A. Perrin S.  The Effect of Titanium Debris on Soft-Tissue Response. Journal of Materials Science: Materials in Medicine 1994; 5: 381-383.doi: 10.1007/BF00058968

Ungersbock A. Hunt JA. Comparison of Visual Controlled and Automatic Histomorphometric Evaluation of Soft Tissue. Journal of Materials Science: Materials in Medicine 1994; 5: 702-704.DOI: 10.1007/BF00120360

Hunt JA. Abrams KR. Williams DF.  Modelling the Pattern of Cell Distribution Around Implanted Materials. Analytical Cellular Pathology 1994; 7: 43-52.

Hunt JA. Van der Laan JS. Schakenraad J. Williams DF. Quantitative in vivo Assessment of the tissue response to Dermal Sheep Collagen in Abdominal Wall Defects. Biomaterials 1993;14:376-382.doi:10.1016/0142-9612(93)90058-A

Khor E. Hunt JA. Martin PA. Doherty PJ. Williams RL. Williams DF. Non-invasive Magnetic Resonance Imaging of the Soft Tissue Response to a Biomaterial. Clinical Materials 1993; 12: 65-72.doi:10.1016/0267-6605(93)90051-8

Hunt JA. Vince DG. Williams DF. Image-Analysis in the Evaluation of Biomaterials. Journal of Biomedical Engineering 1993; 15: 39-45.doi:10.1016/0141-5425(93)90091-C

Campoccia D. Hunt JA. Doherty PJ. Zhong SP. Callegaro L. Benedetti L. Williams DF. Human Neutrophil Chemokinesis and Polarisation-Induced by Hyaluronic-Acid Derivatives. Biomaterials 1993; 14: 1135-1139.doi:10.1016/0142-9612(93)90156-V

Hunt JA. Remes A. Williams DF. Stimulation of neutrophil movement by metal ions.  Journal of Biomedical Materials Research 1992; 26: 819-828.doi: 10.1002/jbm.820260610

Mohanty M. Hunt JA. Doherty PJ. Annis D. Williams DF.  Evaluation of the Soft Tissue Response to a Poly(urethane urea). Biomaterials 1992; 13: 651-656.doi:10.1016/0142-9612(92)90123-6

Hunt, JA. Williams, DF. Modification of the soft tissue response to implanted materials through the use of an anti-inflammatory drug. J. Materials Science: Materials in Medicine 1992; 3: 160-169.  doi: 10.1007/BF00713443

Slavin JA. Hunt JA. Nash JR. Kingsnorth AN. Williams DF.  Recombinant basic fibroblast growth factor in red blood cell ghosts accelerates incisional wound healing. Br. J. Surg. 1992; 79: 918-921.doi: 10.1002/bjs.1800790921

Hunt JA. Remes A. Williams DF. The effect of metal ions on neutrophil degranulation.  J. Materials Science: Materials in Medicine 1992; 3:.192-198.doi: 10.1007/BF00713449

Vince DG. Hunt JA. Williams DF. Quantitative assessment of the tissue response to implanted biomaterials. Biomaterials 1991; 12: 731-736.   doi:10.1016/0142-9612(91)90021-2

Theses

Cell Material Homeostasis; D.Sc. thesis.Division of Clinical Engineering, University of Liverpool, 2006.

Quantification of the Soft Tissue Response to Implanted Materials ; Ph.D. thesis, Department of Clinical Engineering, University of Liverpool, 1991.

See all of John Hunt's publications...

Press expertise

  • Medical technologies
  • Medical devices
  • Stem cells
  • Tissue engineering
  • Regenerative medicine
  • Biomaterials
  • Advanced materials