Role
Senior Lecturer in Microbiology
Career overview
I carried out my undergraduate degree in Biology at the Universidad de Los Andes in Merida (Venezuela), followed by an MPhil in Computational Biology at the University of Cambridge.
I completed my PhD (DPhil) in 2012 at the University of Oxford, working on mathematical models of cell cycle control with Prof Bela Novak.
I then obtained a Wellcome Trust-funded Fellowship to work on cell differentiation in trypanosomes at the Centre for Immunity, Infection and Evolution at the University of Edinburgh (with Prof Keith Matthews). Afterwards, I carried out postdoctoral research on experimental evolution in fission yeast (at the Institute for Genetics and Development in Rennes, France), and on models and analysis of prokaryote pangenomes (at the University of Nottingham with Prof James McInerney).
I joined NTU as a Lecturer in Microbiology in 2021.
Research areas
My research focuses on combining systems and evolutionary biology to understand the function, architecture and evolution of biochemical networks and genomes. Approaches include computational analysis, mathematical modelling and experimental evolution. Current interests include understanding the effects of bacterial diversity on the evolution of antibiotic resistance, the evolution of cell cycle control in eukaryotes and gene content diversity in microbes (prokaryotes and eukaryotes).
External activity
Member of: Microbiology Society, Genetics Society, Society for Molecular Biology and Evolution, Society for Applied Microbiology.
Publications
Selected:
Domingo-Sananes MR* and McInerney JO*. (2021) Mechanisms that shape pangenomes. Trends in Microbiology. 29(6): 493-503. *Co-corresponding authors.
Hall RJ, Whelan FJ, McInerney JO, Ou Y, Domingo-Sananes MR*. (2020) Horizontal gene transfer as a driver of conflict and cooperation in prokaryotes. Frontiers in Microbiology. 11: 1569. *Corresponding author
Callens C, Coelho NC, Miller AW, Domingo Sananes MR, Dunham MJ, Denoual M, Coudreuse D. (2017) A multiplex culture system for the long-term growth of fission yeast cells. Yeast. 34:343-355.
Domingo-Sananes MR, Szöőr B, Ferguson MA, Urbaniak MD, Matthews KR. (2015) Molecular control of irreversible bistability during trypanosome developmental commitment. The Journal of Cell Biology. 211(2):455-68.
Lu LX, Domingo-Sananes MR, Huzarska M, Novak B, Gould KL. (2012) Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches. Proceedings of the National Academy of Sciences USA. 109(25):9899-904.
Domingo-Sananes MR, Kapuy O, Hunt T, Novak B. (2011) Switches and Latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis. Philosophical Transactions of the Royal Society B Biological Sciences. 366(1584):3584-94