Dr Samantha McLean is a lecturer in Microbiology. She is a member of the Pathogen Research Group and is actively engaged in antimicrobial research. She is a Masters and undergraduate degree project supervisor and currently teaches on the following modules:
- Introduction to Microbiology
- Infectious Diseases and their Control
- Clinical and Public Health Microbiology
- Applied Microbiology
Dr McLean received a BSc (Hons) degree in Microbiology at the University of Leeds before moving to the University of Sheffield where she completed her PhD in the department of Molecular Biology and Biotechnology. She also spent a further six years at the University of Sheffield as a Research Associate investigating the interaction of enterobacteria with small molecules of the innate immune response, including reactive oxygen species, reactive nitrogen species and carbon monoxide.
Dr McLean went on to spend two years at the University of Nottingham as a Research Fellow before taking up the position of Lecturer in Microbiology at Nottingham Trent University in February 2016.
Dr McLean is a member of the Pathogen Research Group. Her research interests include investigating the interaction between bacterial pathogens and small molecules of the host innate immune response as well as the exploring the efficacy of novel antimicrobial compounds.
Current research is focussed on evaluating the antimicrobial activity of reactive small molecules and metal compounds both in vitro and when applied to medical devices.
Previous research has included the investigation of oxidative and nitrosative stress in enterobacteria and the use of carbon monoxide releasing molecules as novel antimicrobial agents.
- CO-releasing molecules have non-heme targets in bacteria: transcriptomic, mathematical modelling and biochemical analyses of CORM-3 [Ru(CO)3Cl(glycinate)] actions on a heme-deficient mutant of Escherichia coli. Wilson JL, Wareham L, McLean S, Begg R, Greaves S, Mann BE, Sanguinetti G and Poole RK, Antioxidants and Redox Signalling, 2015, 23, 148-162
- Interaction of the carbon monoxide-releasing molecule Ru(CO)3CL(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of CO binding by integrating cavity dual beam spectrophotometry. Rana N, McLean S, Mann BE and Poole RK, Microbiology, 2014, 160, 2771-2779
- Introducing [Mn(CO)3(tpa-k3N)]+ as a novel photoactivatable CO-releasing molecule with well-defined iCORM intermediates - synthesis, spectroscopy, and antibacterial activity. Nagel C, McLean S, Poole RK, Braunschweig H, Kramer T and Schatzschneider U, Dalton Transactions, 2013, 43, 9986-9997
- Analysis of the bacterial response to Ru(CO)3Cl(glycinate) (CORM-3) and the inactivated compound identifies the role played by the ruthenium compound and reveals sulphur-containing species as a major target of CORM-3 action. McLean S, Begg R, Jesse HE, Mann BE, Sanguinetti G and Poole RK, Antioxidants and Redox Signalling, 2013, 17, 1999-2012
- Sulfite species enhance CO release from CO-releasing molecules: Implications for the deoxymyoglobin assay of activity. McLean S, Mann BE and Poole RK, Analytical Biochemistry, 2012, 427, 36-40
- Peroxynitrite stress is exacerbated by flavohaemoglobin-derived oxidative stress in Salmonella Typhimurium and is relieved by nitric oxide. McLean S, Bowman LAH and Poole RK, Microbiology, 2010, 156, 3556-3565
- Peroxynitrite toxicity in Escherichia coli K12 elicits expression of oxidative stress responses and protein nitration and nitrosylation. McLean S, Bowman LAH, Sanguinetti G, Read RC and Poole RK, Journal of Biological Chemistry, 2010, 285, 20724-20731
- KatG from Salmonella Typhimurium is a peroxynitritase. McLean S, Bowman LAH and Poole RK, FEBS Letters, 2010, 584, 1628-1632