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Lesley Hoyles

Associate Professor

School of Science & Technology

Staff Group(s)
Bioscience

Role

Dr Hoyles is an Associate Professor in Microbiology, focusing on microbiome research. She has a unique combination of skills (microbiology, computational biology) that allows her to use various omics technologies (microbiomics, transcriptomics, metabolomics) in vitro and in vivo to understand how members of the microbiome function and influence human health and disease. This integrated systems-level approach has allowed her to define the contribution of the microbiome and its metabolites to non-alcoholic fatty liver disease, metabolic retroconversion and integrity of the blood–brain barrier.

Career overview

August 2018 – present: Associate Professor (Reader) in Microbiology, Nottingham Trent University, UK.

March 2016 – July 2018: MRC Intermediate Research Fellow (UK Med-Bio), Imperial College London, UK.

November 2014 – February 2016: Lecturer in Microbiology, University of Westminster, UK.

October 2012 – November 2014: Postdoctoral Research Associate in Bioinformatics and Translational Systems Biology, Imperial College London, UK.

October 2011 – September 2012: Advanced MRC scholar, MSc (DIC) Bioinformatics and Theoretical Systems Biology, Imperial College London, UK.

October 2009 – September 2011: Government of Ireland Postdoctoral Fellow in Science, Engineering and Technology (IRCSET scheme), University College Cork, Ireland.

Research areas

Dr Hoyles started her career as a taxonomist, characterizing novel fastidious Gram-positive anaerobes isolated from clinical and veterinary sources.

Her GlaxoSmithKline-funded PhD, at the University of Reading, focused on using in vitro fermentation systems to understand the effect of an anti-obesity therapy on the human gut microbiota and its lipolytic activity. She then secured a Fellowship at University College Cork to work in the bacteriophage research group of Professor Douwe van Sinderen, developing methods to improve recovery and characterization of bacteriophage populations within the human gut.

Since training as a computational biologist, Dr Hoyles has worked extensively in the field of systems biology. Most recently, she has worked on numerous animal and human studies integrating microbiomic, metabolomic and transcriptomic data to better understand how the microbiome and its metabolites influence intestinal and systemic health.

Her current research interests include/incorporate:

  • Coriobacteriia associated with the gut microbiota
  • Shotgun metagenomics (microbiome and virome)
  • Transcriptomics (eukaryote and prokaryote)
  • Effect of gut-derived microbial metabolites on host health
  • Use of in vitro systems to study diet–microbiome interactions
  • Intestinal Klebsiella pneumoniae and Klebsiella oxytoca and their bacteriophages

Opportunities to undertake postgraduate research towards an MPhil/PhD exist within the School of Science and Technology. Further information can be obtained from the NTU Doctoral School.

External activity

Chartered Biologist (Royal Society of Biology).

Professional memberships

Member of the Royal Society of Biology
Member of the Microbiology Society
Member of the American Society for Microbiology
Member of the Society for Applied Microbiology
Member of the Healthcare Infection Society
Member of the British Society for Antimicrobial Chemotherapy

Peer review

Refer to Dr Hoyles’s publons record for details of journals she has reviewed manuscripts for. She is an Academic Editor for PeerJ.

Dr Hoyles regularly reviews grants for the BBSRC, Wellcome Trust and The Netherlands Organisation for Health Research and Development (ZonMw).

Outreach activities

Dr Hoyles is a STEM Ambassador and runs Bugs In Your Guts.

Sponsors and collaborators

Current and former collaborators

Dr Alan Walker, University of Aberdeen, UK
Dr Anne L. McCartney, University of Reading, UK
Dr David Randall and Professor Magdi Yaqoob, William Harvey Research Institute, UK
Dr James Abbott, University of Dundee, UK
Dr Jon Swann, Imperial College London, UK
Dr Lindsay Hall, Quadram Institute, UK
Dr Marc-Emmanuel Dumas, Imperial College London, UK
Dr Michael Cox, Imperial College London, UK
Dr Pamela Greenwell, University of Westminster, UK
Dr Sarah Butcher, EMBL-EBI, UK
Dr Simon McArthur, Blizard Institute, UK
Professor Edward Moore, Culture Collection University of Gothenburg, Sweden, UK
Professor Glenn Gibson, University of Reading, UK
Professor John Wallace, University of Aberdeen, UK
Professor José-Manuel Fernández-Real, Hospital of Girona "Dr Josep Trueta", Spain
Professor Massimo Federici, University of Rome Tor Vergata, Italy
Professor Rémy Burcelin, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Professor Sandhya Visweswariah, Indian Institute of Science, Bangalore, India
Professor Simon Carding, Quadram Institute, UK
Professor Stella Knight, Imperial College London, UK

Funders past and present

Medical Research Council
Alzheimer’s Research UK
GlaxoSmithKline
Microbiology Society
British Society for Antimicrobial Chemotherapy
Irish Research Council for Science, Engineering and Technology

Publications

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women. Hoyles L et al, Nature Medicine, 2018, 24, 1070-1080.

See all of Lesley Hoyles's publications...

Press expertise

Gut microbiome, gut microbiota, translational systems biology.