This Centre encompasses research in Biomedical Sciences and Allied Health and aligns with the Health and Wellbeing strategic theme and the Biosciences subject area here at NTU. Our research is structured around aspects of health and disease taking into account development and ageing.
The research investigates disease processes with the aim of seeking prevention, incorporating lifestyle approaches and environmental impacts as well as therapies and utilising a wide range of methods across the span of scientific disciplines.
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Cancer Biology, Immunology and Therapeutics conducts fundamental and translational research into a range of cancers, including breast, colorectal, pancreatic, liver, prostate, skin (malignant melanoma), brain (glioblastoma multiforme) and ovarian, as well as acute leukaemia and other haematological malignancies and on novel therapeutic options.
Research focuses on the unmet clinical needs via pre-clinical and clinical research into the identification of biomarkers for diagnostic, disease prediction and therapeutic response. We are also developing peptide and DNA-based vaccines and cell-based immunotherapeutic strategies for the treatment of aggressive disease. These studies are interrogating important molecular pathways and the key events associated with malignancy using state-of-the-art analytical platforms such as cell cytometry, mass spectrometry and gene expression arrays, and are supported by advanced bioinformatics and computational capabilities.
- Leads: Professor Graham Pockley, Dr Christos Polytarchou and Professor Sergio Rutella.
- Members: David Boocock, Amanda Coutts, Karin Garrie, Maria Hatziapostolou, Glen Kirkham, Stephanie McArdle, Amanda Miles, Cristina Montiel-Duarte, Tarik Regad and Christopher Tinsley.
Antimicrobial Resistance, Omics & Microbiota incorporates classical microbiology (aerobic, microaerophilic, anaerobic), molecular biology, systems biology and bioinformatics. Members of the group work on mechanisms of microbial pathogenesis, factors influencing development of antimicrobial resistance, development of novel antimicrobials, population genomics and epidemiology, diversity of the human gut microbiota, host–microbiome interactions, predator–prey interactions, evolution of virulence, and plasmid biology and evolution.
- Leads: Dr Lesley Hoyles and Dr Jody Winter.
- Members: Benjamin Dickins, Michael Loughlin, Naqash Masood, Samantha McLean, Gareth McVicker, David Negus, Jonathan Thomas and Selman Ali.
- International Collaborations: We currently work with researchers at ITQB NOVA, Portugal; Mississippi State University; University of Mississippi Medical Center (UMMC); National Centre for Cell Science, Pune, India; Indian Institute of Science, Bangalore, India; Makerere University School of Public Health, Kampala, Uganda; King Mongkut’s University of Technology Thonburi, Bangkok, Thailand.
Diabetes, Chronic Diseases and Ageing supports a multi-disciplinary translational team focussed on understanding the fundamental pathophysiology of type 2 diabetes, inflammatory based chronic diseases (Kidney, Asthma, Cardiovascular) and neuro-centred diseases of ageing (Alzheimer's, Parkinson’s and other neurological alterations). The research’s ambition is to investigate molecular mechanisms and dysfunction leading to disease to provide therapeutic insights and interventions for patient benefits.
- Leads: Dr Alan Hargreaves, Dr Mark Turner and Dr Elisabetta Verderio-Edwards.
- Diabetes: Adiakala Antonysunil, Sergio Colombo, Craig Doig, Richard Hulse, Philip McTernan, Barbara Pierscionek, Alex Robinson and Mark Turner.
- Chronic Diseases: John Dickenson, Yasser El-Sherbiny, John Hunt, Carl Nelson and Elisabetta Verderio-Edwards.
- Ageing: Zahraa Al-Ahmady, Philip Bonner, Ellen Billett, Luigi De Girolamo, Fiona Freeman, Alan Hargreaves, Christian Thode, Aslihan Ugun-Klusek, and Mohammed Ahmed.
Health of the Environment is a newly developed group which aims to employ a truly multi-disciplinary scientific approach to understanding the impact of human activities on the environment. Members of our group investigate the ecological consequences of our rapidly changing environments, with the ultimate goal of translating these research advances into management actions that protect ecosystems and the services they provide to our society. Through our broad range of expertise areas, we share the ambition of exploring natural environments from the genes to the global ecosystem level, to provide insights that inform interventions that enhance the capacity of ecosystems to function effectively.
- Leads: Dr Daniel Pincheira-Donoso and Dr Rachel Stubbington.
- Members: Carlos Abrahams, George Bunting, Ben Dickens, Lilly P. Harvey, Chloe Hayes, Frederick Owen, Chris Lloyd Mills, Peter Redfern, Romain Sarremejane, Chris Terrell-Nield and Erika Whiteford.
The groups are underpinned by cross cutting methods and technologies:
Bioinformatics and Biomathematics develops new mathematical approaches based upon matrix computations, computational graph theory, Kolmogorov’s complexity, Bayesian inference, computational statistics, continuum mechanics and dynamical systems theory for:
- discovering important structural and functional features within large real-world networks and understanding complex systems, particularly those arising in biology;
- mining the data from post genomic technologies including, mass spectrometry, gene expression array and flow cytometry;
- modelling mechanisms of mutations causing human genetic disease and cancer;
- modelling soft tissue growth, sexually-transmitted infections, and tissue engineering.
The group has well established research collaborations with various institutions in the UK and abroad. It also provides bioinformatics and biomathematics expertise supporting both laboratory-based and in silico analyses currently being undertaken by the Neurobiology groups and the John van Geest Cancer Research Centre.
- Leads: Professor Graham Ball and Professor Nadia Chuzhanova
- Members: Benjamin Dickins, David Chappell, Jonathan Crofts, Archontis Giannakidis, Martin Nelson, David Robinson and Golnaz Shahtahmassebi.
Therapeutic and Computational Chemistry, Analysis and Imaging uses state of the art analytical and synthetic techniques to develop methods and materials to investigate biological processes and structures; bio-inspired compounds for use as potential drugs.
NIHR, Pancreatic Cancer UK, Wellcome Trust, Sidra Medical and Research Centre, The Headcase Cancer Trust, Incyte Corporation, Roger Counter Foundation, Qatar National Research Fund, NanoString Technologies, MacroGenics, ImmuneBio International Ltd. UCB, NERC, Microsoft, UK Foreign and Commonwealth Office Zeiss, Innovate UK-KTP, The Headcase Cancer Trust