Cracking the cancer code.
Acute myeloid leukaemia (AML) is one of the most aggressive types of blood cancers - with just one in five patients surviving beyond five years of their diagnosis. For patients that don’t respond well to chemotherapy, the life-expectancy is just four months. Currently, we do not properly understand why some cancer therapies are unsuccessful, making it difficult for clinicians to administer the right treatment to each cancer patient.
Researchers from NTU's John van Geest Cancer Research Centre are tackling this. They’re investigating the use of a patient’s own immune system to fight cancer – a process known as immunotherapy – and conducting research into the genetic profile of tumours. Their aim is to identify new ways of targeting immune suppression caused by cancer and to repair the ability of the immune system to eliminate cancer cells, without the need for tissue-damaging chemotherapy.
Using advanced, cross-disciplinary technologies - and collaborating with pharmaceutical partners – our researchers have already identified the specific genes present in patients who have responded well to a new AML immunotherapy drug. These discoveries will help allocate therapies based on the genes of each individual patient, allowing clinicians to tailor treatments.
NTU is cracking the cancer code by developing novel cancer therapies for aggressive tumours, and sparing patients from unnecessary and dangerous treatments.
This research was recently submitted to the Allied Health Professions, Dentistry, Nursing and Pharmacy Unit of Assessment in the Research Excellence Framework (REF) 2021, where 99% of the research was rated as world-leading or internationally excellent in terms of quality.
Explore the latest news and projects
Exercise prompts cells to react in a way that could protect against bone cancer and other bone-related illnesses, research suggests
Mon 5 Jul 2021
Gene could guide better treatment of most common breast cancer
Wed 5 Aug 2020
Funding will allow clinical trials for COVID-19 vaccine to begin in Nottingham
Thu 27 Aug 2020
New blood test can confirm prostate cancer – and what stage it is at
Tue 28 Jul 2020
Study paves way for faster, more accurate therapies for hard-to-treat leukaemia patients
Thu 4 Jun 2020
Scientists developing new vaccine approach for most aggressive brain cancer
Tue 25 Feb 2020
Centre for Health, Ageing and Understanding Disease (CHAUD)
CHAUD is structured around four themes covering various aspects of human health and chronic diseases, including cancers which are treatable but not curable, diabetes and other inflammatory conditions.
Re:gister for updates
Our research community is committed to delivering innovative solutions to some of the world’s most pressing challenges. Sign up for email alerts to follow their progress and to stay connected to the latest research developments and opportunities at NTU.
Helping surgeons prepare for life-saving operations.
Creating the homes of the future.
Fighting to make women’s safety everyone’s responsibility
Using future tech to protect the past.
Transforming a regular craft into a remarkable revolution.
Feeding the growing population without further harming our fragile planet.
Rethinking how individuals interact in our online world.
Understanding language, dialect, and their role in building our sense of self.
Creating a buzz in animal behaviour.