Allied Health Professions, Dentistry, Nursing and Pharmacy
The research conducted in these subject areas aims to further our understanding of the molecular and cellular basis of health and disease and to develop enabling tools to fulfil this goal.
Our research in the Allied Heath Professions, Dentistry, Pharmacy and Nursing subject area investigates disease processes with the aim of seeking prevention, incorporating lifestyle approaches and environmental impacts as well as therapies and utilising a wide range of methods across the span of scientific disciplines.
Research staff are drawn from both the Centre for Health, Ageing and Understanding Disease (CHAUD) and the John van Geest Cancer Research Centre, and have diverse academic backgrounds (Biochemistry, Pharmacology, Immunology, Microbiology, Bioinformatics, Biomathematics and Analytical / Synthetic Chemistry), allowing ample opportunity for cross-discipline research.
We have strong partnerships with the health service (UK and worldwide) and companies aspiring to offer an improved service for both the public and clinicians. Our world-class research is supported by high-tech facilities, extensive national and international collaborations and a diverse range of funding sources including:
- UK-based charities
- SMEs and government bodies
- Research councils
- EU and global companies
Cancer Biology, Immunology and Therapeutics conducts fundamental and translational research into a range of cancers, including breast, colorectal, pancreatic, liver, prostate, skin (malignant melanoma), brain (glioblastoma multiforme) and ovarian, as well as acute leukaemia and other haematological malignancies and on novel therapeutic options: tumor suppressor genes (p53, PML), epigenetics of oncogenic transformation, cell based therapeutics. Targeting histone modifiers, microRNAs and lncRNAs are being evaluated in pre-clinical animal models, either as stand-alone or combinatorial therapies. This group is linked with the John van Geest Cancer Centre.
Antimicrobial Resistance, Omics & Microbiota focus on mechanisms of pathogenesis, evolution of virulence and approaches to anti-microbial therapy and microbiota in health and disease.
Diabetes, Chronic Diseases and Ageing focusses on understanding the fundamental pathophysiology of type 2 diabetes, inflammatory based chronic diseases (e.g. Kidney, Asthma, Cardiovascular disease) and neurological centred diseases of ageing (e.g. Alzheimer's, Parkinson’s and other neurological alterations) pioneering work on extracellular vesicles, matrix biology and transglutaminases.
Neurobiology, Toxicology and Pharmacology is interested in memory formation; brain development and neural organisation; models of neurodegeneration, pain, toxicity and neural implants, cell signalling in cardioprotection and control of asthma.
Bioinformatics and Biomathematics is concerned with development of mathematical, statistical and computational approaches addressing some of the post genomic challenges. The group consists of experts from Biosciences, Chemistry and Forensics and Physics and Mathematics with skills and interests that underpin a number of other areas and work across groups and centres.
Therapeutic and Computational Chemistry, Analysis and Imaging uses state of the art analytical and synthetic techniques to develop methods and materials to investigate biological processes and structures and bio-inspired compounds for use as potential drugs.
Proteomics and Genomics This interdisciplinary group conducts research using cutting edge technologies to analyse the genome, epigenome and proteome in order to gain insight into mechanisms of human diseases, cell biology, evolutionary processes.